Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

蛋白

磷酸酶张力蛋白同源基因(人类),(重组)(多聚组氨酸标签)

BML-SE402-0010

10微克

BML-SE402-0010

磷酸酶张力蛋白同源基因(人类),(重组)(多聚组氨酸标签)

蛋白

10微克

PTEN (phosphatase and tensin homologue deleted on chromosome 10, MMAC) is a lipid phosphatase which can also act as a tyrosine, serine and threonine protein phosphatase. It is specific for acidic substrates such as phosphatidylinositol(3,4,5)-trisphosphate, which is its main biological substrate that mediates growth factor-induced activation of intracellular signalling through the serine-threonine kinase Akt. The tumor suppressor gene, PTEN, also known as MMAC1 or TEP1, has been isolated from a locus on chromosome 1Oq23; this protein is deleted or mutated in a large number of tumors. Germline mutations of PTEN have been identified in Cowden disease, Lhermitte-Duclos disease, and Bannayan-Zonana syndrome.

Phosphatase and tensin homolog deleted on chromosome 10

≥80%(十二烷基磺酸钠-PAGE)

Liquid. In 50mM TRIS-HCl, pH 8.0, containing 150mM sodium chloride, 5mM DTT, 0.03% Brij 35, 0.1mM EDTA and 20% glycerol.

Can be used to study regulation and kinetics of PTEN, screen for PTEN inhibitors or activators or as positive control for Western blots.

-80°C