产品简要
公司名称 :
Enzo Life Sciences
其他品牌 :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
产品类型 :
蛋白
产品名称 :
LSD1(人类),(重组)
目录 :
BML-SE544-0050
规格 :
50微克
更多信息或购买 :
文章摘录数: 1
参考文献
Sakane C, Ohta H, Shidoji Y. Measurement of lysine-specific demethylase-1 activity in the nuclear extracts by flow-injection based time-of-flight mass spectrometry. J Clin Biochem Nutr. 2015;56:123-31 pubmed 出版商
产品信息
产品编号 :
BML-SE544
目录代码 :
BML-SE544-0050
产品名称 :
LSD1(人类),(重组)
产品类型 :
蛋白
规格 :
50微克
Pubmed号列表 :
25759518
背景 :
The mono, di- and trimethylation of particular lysine residues in histone tails (e.g. histone H3 lysine-4 (H3K4), H3K9, H3K27, H3K36, H4K20) are implicated, along with a variety of other post-translational modifications (e.g. lysine acetylation) in the transmission of heritable epigenetic information and the control of chromatin structure and DNA transcription. LSD1 catalyzes the oxidative demethylation of mono- and dimethylated H3K4, producing hydrogen peroxide and formaldehyde in the process. H3K4 methylation is considered a transcription activating chromatin mark and in vivo LSD1 is frequently found in association with the transcriptional corepressor protein CoREST and HDACs 1 or 2. LSD1 is inhibited by a number of established monoamine oxidase inhibitor drugs. That and the fact that its expression is elevated in a number of cancers may make it a promising target for drug development.
别名 :
KDM1, Lysine-specific histone demethylase 1, BHC110, AOF2, KIAA0601
纯度 :
≥90%(十二烷基磺酸钠-PAGE)
缓冲液 :
液体。 在8.1mM Na2HPO4, 1.5mM磷酸二氢钾, pH值7.2, 138mM氯化钠, 2.7mM氯化钾和40% v/v甘油
用途 :
Useful tool to study LSD1 kinetics and inhibitor sensitivity and also the effect of the enzyme in transcriptional regulation, cell cycle progression, and oncogenesis.
储存 :
-80°C
更多信息或购买 :
公司信息
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
techserv-usa@enzolifesciences.com
https://www.enzolifesciences.com
1-800-942-0430
公司总部: 美国
自2007年始,Enzo Life Sciences先后合并ALEXIS Biochemicals、BIOMOL International等公司,为生命科学研究各个领域提供更全面的试剂产品。比如,肿瘤、细胞死亡、表观遗传、基因组学、免疫学、神经科学、信号转导及泛素和蛋白酶体等领域研究,都可以在Enzo Life Sciences中找到相应抗体、酶、蛋白、小分子抑制剂、产品文库及检测kit等产品。