产品简要
公司名称 :
Enzo Life Sciences
其他品牌 :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
产品类型 :
蛋白
产品名称 :
TRAIL (soluble) (human), (recombinant) (His-tag)
目录 :
BML-SE721-0100
规格 :
100微克
更多信息或购买 :
Enzo Life Sciences 产品网页
文章摘录数: 11
参考文献
Moriwaki K, Shinzaki S, Miyoshi E. GDP-mannose-4,6-dehydratase (GMDS) deficiency renders colon cancer cells resistant to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor- and CD95-mediated apoptosis by inhibiting complex II formation. J Biol Chem. 2011;286:43123-33 pubmed 出版商
Chen K, Yeh P, Hsu C, Hsu C, Lu Y, Hsieh H, et al. Bortezomib overcomes tumor necrosis factor-related apoptosis-inducing ligand resistance in hepatocellular carcinoma cells in part through the inhibition of the phosphatidylinositol 3-kinase/Akt pathway. J Biol Chem. 2009;284:11121-33 pubmed 出版商
Panaretakis T, Kepp O, Brockmeier U, Tesniere A, Bjorklund A, Chapman D, et al. Mechanisms of pre-apoptotic calreticulin exposure in immunogenic cell death. EMBO J. 2009;28:578-90 pubmed 出版商
Shanker A, Brooks A, Tristan C, Wine J, Elliott P, Yagita H, et al. Treating metastatic solid tumors with bortezomib and a tumor necrosis factor-related apoptosis-inducing ligand receptor agonist antibody. J Natl Cancer Inst. 2008;100:649-62 pubmed 出版商
Méndez E, Aguirre Crespo G, Zavala G, Arias C. Association of the astrovirus structural protein VP90 with membranes plays a role in virus morphogenesis. J Virol. 2007;81:10649-58 pubmed
Hasegawa H, Yamada Y, Komiyama K, Hayashi M, Ishibashi M, Sunazuka T, et al. A novel natural compound, a cycloanthranilylproline derivative (Fuligocandin B), sensitizes leukemia cells to apoptosis induced by tumor necrosis factor related apoptosis-inducing ligand (TRAIL) through 15-deoxy-Delta 12, 14 prostaglandin J2 producti. Blood. 2007;110:1664-74 pubmed
Sun S, Liu X, Zou W, Yue P, Marcus A, Khuri F. The farnesyltransferase inhibitor lonafarnib induces CCAAT/enhancer-binding protein homologous protein-dependent expression of death receptor 5, leading to induction of apoptosis in human cancer cells. J Biol Chem. 2007;282:18800-9 pubmed
Bhattacharyya N, Pechhold K, Shahjee H, Zappala G, Elbi C, Raaka B, et al. Nonsecreted insulin-like growth factor binding protein-3 (IGFBP-3) can induce apoptosis in human prostate cancer cells by IGF-independent mechanisms without being concentrated in the nucleus. J Biol Chem. 2006;281:24588-601 pubmed
Bernal Mizrachi L, Lovly C, Ratner L. The role of NF-{kappa}B-1 and NF-{kappa}B-2-mediated resistance to apoptosis in lymphomas. Proc Natl Acad Sci U S A. 2006;103:9220-5 pubmed
Ma Y, Lakshmikanthan V, Lewis R, Kumar M. Sensitization of TRAIL-resistant cells by inhibition of heat shock protein 90 with low-dose geldanamycin. Mol Cancer Ther. 2006;5:170-8 pubmed
Hasegawa H, Yamada Y, Komiyama K, Hayashi M, Ishibashi M, Yoshida T, et al. Dihydroflavonol BB-1, an extract of natural plant Blumea balsamifera, abrogates TRAIL resistance in leukemia cells. Blood. 2006;107:679-88 pubmed
产品信息
产品编号 :
BML-SE721
目录代码 :
BML-SE721-0100
产品名称 :
TRAIL (soluble) (human), (recombinant) (His-tag)
产品类型 :
蛋白
规格 :
100微克
Pubmed号列表 :
22027835, 19261616, 19165151, 18445820, 17652389, 17551094, 17493934, 16793770, 16751281, 16432176
物种活性 :
人类, 小鼠
背景 :
TRAIL, also called Apo2L, is a member of the tumor necrosis factor family (TNF). In contrast to other family members such as TNFa/TNFR1 and FasL/Fas, TRAIL and its receptors DR4 and DR5 are widely expressed in many human tissues. TRAIL activates rapid apoptosis in many transformed cell lines but not in normal tissues, even though TRAIL and its receptors DR4 and DR5 are expressed on both cell  types. A glycophospholipid-anchored cell surface protein designated decoy receptor 1 (DcR1 or TRID) acts as a decoy to inhibit TRAIL signaling. Thus, TRAIL and its signaling pathways may have direct applications in selective tumor cell death and cancer research.
别名 :
ApoE基因2L, TNFSF 10, CD253
特异性 :
Binds to human and mouse TRAIL receptors and human osteoprotegerin (OPG).
纯度 :
≥95%(十二烷基磺酸钠-PAGE)
缓冲液 :
液体。 在10mM Na2HPO4, 2mM磷酸二氢钾, 2.7mM氯化钾, 500mM氯化钠, 10% 甘油, 0.1mM DTT
储存 :
-80°C
更多信息或购买 :
Enzo Life Sciences 产品网页
公司信息
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
techserv-usa@enzolifesciences.com
https://www.enzolifesciences.com
1-800-942-0430
公司总部: 美国
自2007年始，Enzo Life Sciences先后合并ALEXIS Biochemicals、BIOMOL International等公司，为生命科学研究各个领域提供更全面的试剂产品。比如，肿瘤、细胞死亡、表观遗传、基因组学、免疫学、神经科学、信号转导及泛素和蛋白酶体等领域研究，都可以在Enzo Life Sciences中找到相应抗体、酶、蛋白、小分子抑制剂、产品文库及检测kit等产品。