产品简要
公司名称 :
Enzo Life Sciences
其他品牌 :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
产品类型 :
化学品
产品名称 :
长春新碱。 硫酸盐
目录 :
BML-T117-0025
规格 :
25毫克
更多信息或购买 :
文章摘录数: 10
参考文献 |
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Mabjeesh N, Escuin D, LaVallee T, Pribluda V, Swartz G, Johnson M, et al. 2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF. Cancer Cell. 2003;3:363-75 pubmed
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Vilpo J, Koski T, Vilpo L. Selective toxicity of vincristine against chronic lymphocytic leukemia cells in vitro. Eur J Haematol. 2000;65:370-8 pubmed
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Groninger E, de Graaf S, Meeuwsen de Boer G, Sluiter W, Poppema S. Vincristine-induced apoptosis in vivo in peripheral blood mononuclear cells of children with acute lymphoblastic leukaemia (ALL). Br J Haematol. 2000;111:875-8 pubmed
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Wang L, Liu X, Kreis W, Budman D. The effect of antimicrotubule agents on signal transduction pathways of apoptosis: a review. Cancer Chemother Pharmacol. 1999;44:355-61 pubmed
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Poruchynsky M, Wang E, Rudin C, Blagosklonny M, Fojo T. Bcl-xL is phosphorylated in malignant cells following microtubule disruption. Cancer Res. 1998;58:3331-8 pubmed
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Jordan A, Hadfield J, Lawrence N, McGown A. Tubulin as a target for anticancer drugs: agents which interact with the mitotic spindle. Med Res Rev. 1998;18:259-96 pubmed
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Blagosklonny M, Giannakakou P, El Deiry W, Kingston D, Higgs P, Neckers L, et al. Raf-1/bcl-2 phosphorylation: a step from microtubule damage to cell death. Cancer Res. 1997;57:130-5 pubmed
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Hamel E. Antimitotic natural products and their interactions with tubulin. Med Res Rev. 1996;16:207-31 pubmed
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Zhang J, Alter N, Reed J, Borner C, Obeid L, Hannun Y. Bcl-2 interrupts the ceramide-mediated pathway of cell death. Proc Natl Acad Sci U S A. 1996;93:5325-8 pubmed
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产品信息
产品编号 :
BML-T117
目录代码 :
BML-T117-0025
产品名称 :
长春新碱。 硫酸盐
产品类型 :
Biochemical
规格 :
25毫克
Pubmed号列表 :
26134503, 12726862, 11168494, 11122150, 10501907, 9699663, 9664292, 8988053, 8656780, 8643573
产品描述 :
Plant alkaloid that arrests the cell cycle in G2/M phase by blocking mitotic spindle formation. Depolymerizes microtubules and blocks binding of tubulin to microtubule proteins. Causes aberrant tubulin polymerization. Induces apoptosis. Triggers Raf-1 activation, phosphorylation of Bcl-2 family proteins and induction of p53 expression. Cancer chemotherapeutic agent. Posttranscriptionally downregulates HIF-1α expression.
别名 :
VCR . sulfate, Leukocristine . sulfate
纯度 :
≥98% (Assay)
储存 :
-20°C
更多信息或购买 :
公司信息
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
Ann Arbor, MI 48108
techserv-usa@enzolifesciences.com
https://www.enzolifesciences.com1-800-942-0430
公司总部: 美国
自2007年始,Enzo Life Sciences先后合并ALEXIS Biochemicals、BIOMOL International等公司,为生命科学研究各个领域提供更全面的试剂产品。比如,肿瘤、细胞死亡、表观遗传、基因组学、免疫学、神经科学、信号转导及泛素和蛋白酶体等领域研究,都可以在Enzo Life Sciences中找到相应抗体、酶、蛋白、小分子抑制剂、产品文库及检测kit等产品。