产品简要
公司名称 :
Enzo Life Sciences
其他品牌 :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
产品类型 :
化学品
产品名称 :
长春新碱。 硫酸盐
目录 :
BML-T117-0025
规格 :
25毫克
更多信息或购买 :
文章摘录数: 10
参考文献
Choi A, Jo M, Jung M, Kim H, Yoon S. Selenate specifically sensitizes drug-resistant cancer cells by increasing apoptosis via G2 phase cell cycle arrest without P-GP inhibition. Eur J Pharmacol. 2015;764:63-9 pubmed 出版商
Mabjeesh N, Escuin D, LaVallee T, Pribluda V, Swartz G, Johnson M, et al. 2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF. Cancer Cell. 2003;3:363-75 pubmed
Vilpo J, Koski T, Vilpo L. Selective toxicity of vincristine against chronic lymphocytic leukemia cells in vitro. Eur J Haematol. 2000;65:370-8 pubmed
Groninger E, de Graaf S, Meeuwsen de Boer G, Sluiter W, Poppema S. Vincristine-induced apoptosis in vivo in peripheral blood mononuclear cells of children with acute lymphoblastic leukaemia (ALL). Br J Haematol. 2000;111:875-8 pubmed
Wang L, Liu X, Kreis W, Budman D. The effect of antimicrotubule agents on signal transduction pathways of apoptosis: a review. Cancer Chemother Pharmacol. 1999;44:355-61 pubmed
Poruchynsky M, Wang E, Rudin C, Blagosklonny M, Fojo T. Bcl-xL is phosphorylated in malignant cells following microtubule disruption. Cancer Res. 1998;58:3331-8 pubmed
Jordan A, Hadfield J, Lawrence N, McGown A. Tubulin as a target for anticancer drugs: agents which interact with the mitotic spindle. Med Res Rev. 1998;18:259-96 pubmed
Blagosklonny M, Giannakakou P, El Deiry W, Kingston D, Higgs P, Neckers L, et al. Raf-1/bcl-2 phosphorylation: a step from microtubule damage to cell death. Cancer Res. 1997;57:130-5 pubmed
Hamel E. Antimitotic natural products and their interactions with tubulin. Med Res Rev. 1996;16:207-31 pubmed
Zhang J, Alter N, Reed J, Borner C, Obeid L, Hannun Y. Bcl-2 interrupts the ceramide-mediated pathway of cell death. Proc Natl Acad Sci U S A. 1996;93:5325-8 pubmed
产品信息
产品编号 :
BML-T117
目录代码 :
BML-T117-0025
产品名称 :
长春新碱。 硫酸盐
产品类型 :
Biochemical
规格 :
25毫克
Pubmed号列表 :
26134503, 12726862, 11168494, 11122150, 10501907, 9699663, 9664292, 8988053, 8656780, 8643573
产品描述 :
Plant alkaloid that arrests the cell cycle in G2/M phase by blocking mitotic spindle formation. Depolymerizes microtubules and blocks binding of tubulin to microtubule proteins. Causes aberrant tubulin polymerization. Induces apoptosis. Triggers Raf-1 activation, phosphorylation of Bcl-2 family proteins and induction of p53 expression. Cancer chemotherapeutic agent. Posttranscriptionally downregulates HIF-1α expression.
别名 :
VCR . sulfate, Leukocristine . sulfate
纯度 :
≥98% (Assay)
储存 :
-20°C
更多信息或购买 :
公司信息
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
techserv-usa@enzolifesciences.com
https://www.enzolifesciences.com
1-800-942-0430
公司总部: 美国
自2007年始,Enzo Life Sciences先后合并ALEXIS Biochemicals、BIOMOL International等公司,为生命科学研究各个领域提供更全面的试剂产品。比如,肿瘤、细胞死亡、表观遗传、基因组学、免疫学、神经科学、信号转导及泛素和蛋白酶体等领域研究,都可以在Enzo Life Sciences中找到相应抗体、酶、蛋白、小分子抑制剂、产品文库及检测kit等产品。