Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

蛋白

USP25 (isoform 2) (human), (recombinant) (His-tag)

BML-UW0475-0050

50微克

BML-UW0475-0050

USP25 (isoform 2) (human), (recombinant) (His-tag)

蛋白

50微克

25961918

Ubiquitin specific protease-25 (USP25) is a vertebrate specific deubiquitinating enzyme. Three alternative splice variants have been identified; two ubiquitously expressed and one, the longer isoform USP25m, restricted to expression in muscular tissues where it is upregulated during myogenesis. Whilst its biological function and regulation have yet to be fully elucidated, increased USP25 expression levels have been observed in Down syndrome fetal brains and in breast cancer tissue. USP25 is also a target for SUMO modification, which takes place within its two ubiquitin intreaction motifs and has been shown to impair it’s binding to and hydrolysis of polyubiquitin chains.

Ubiquitin thioesterase 25, Ubiquitin-specific protease 25, Deubiquitinating enzyme 25, USP on chromosome 21

≥95%(十二烷基磺酸钠-PAGE)

液体。 在50mM TRIS, pH值8.0, 含50mM氯化钠和1mM DTT

Uses:. 1. Deubiquitinylation assays using small molecule substrates (e.g. Ub-AMC, Prod. No. BML-SE211) or ubiquitin-protein conjugates. 2. Studies of the effect of SUMO modification on USP25 activity. 3. Investigation of the role of USP25 in various biological processes. 4. Development of inhibitors for USP25 deubiquitinylating activity.

-80°C