Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

蛋白

Otubain-1 (human), (recombinant) (His-tag)

BML-UW0680-0100

100微克

BML-UW0680-0100

Otubain-1 (human), (recombinant) (His-tag)

蛋白

100微克

Otubain-1 belongs to the ovarian tumor (OTU) domain class of cysteine protease deubiquitinating enzymes and has been implicated in mediating lymphocyte antigen responsiveness and may be generally involved in RNA processing and cell adhesion/morphology. Human otubain-1 has been shown to exhibit high linkage-specificity in vitro, cleaving Lys48 (K48)-linked polyubiquitin but not K63-, K29-, K6-, or K11-linked polyubiquitin, or linear α-linked polyubiquitin. Cleavage is not limited to either end of a polyubiquitin chain, and both free and substrate-linked polyubiquitin are disassembled.

OTUB1, Ubiquitin thioesterase OTUB1, Ubiquitin-specific-processing protease OTUB1, Deubiquitinating enzyme OTUB1

≥95%(十二烷基磺酸钠-PAGE)

液体。 在50mM TRIS, pH值7.5, 含50mM氯化钠和1mM DTT

Uses:. 1. Deubiquitinylation assays using polyubiquitin chains or ubiquitin-protein conjugates. 2. Studies of the K48-linkage specific polyubiquitin chain binding and deubiquitinylation. 3. Investigation of the role of Otubain-1 in various biological processes. 4. Development of inhibitors for Otubain-1 deubiquitinylating activity.

-80°C