Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

蛋白

LC3B(人类),(重组)(谷胱甘肽S-转移酶标签)

BML-UW1155-0500

500微克

BML-UW1155-0500

LC3B(人类),(重组)(谷胱甘肽S-转移酶标签)

蛋白

500微克

Autophagy is a highly conserved bulk protein degradation pathway responsible for the turnover of long-lived proteins, disposal of damaged organelles, and clearance of aggregate-prone proteins. Autophagy is involved in various physiological or pathological processes, such as development, host defense response, cancer and neuronal degenerative diseases. It involves concerted action of more than 20 specific autophagy (ATG) proteins that mediate the formation of a double-membrane vesicle, the autophagosome, which engulfs the substrate and delivers it to the lysosome for degradation. Formation and expansion of the pre-autophagosomal structure in yeast requires the attachment of the ubiquitin-like protein ATG8 via its C-terminal glycine to the amino group of phosphatidylethanolamine (PE), enabling its anchoring to the isolation membrane of the autophagosome. In mammals, ATG8 is represented by at least seven related proteins that fall into two subgroups, LC3- and GABARAP-like proteins. The free and PE linked versions of these proteins are often referred to as LC3-I and LC3-II respectively.

微管相关蛋白1A/1B照明链3B

≥95%(十二烷基磺酸钠-PAGE)

液体。 在PBS

For use in general and selective autophagy studies.

-80°C