泛肽醛,(重组) | Enzo Life Sciences BML-UW8450-0050 产品信息

产品简要

公司名称 :

Enzo Life Sciences

其他品牌 :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

产品类型 :

蛋白

产品名称 :

泛肽醛,(重组)

BML-UW8450-0050

规格 :

50微克

更多信息或购买 :

Enzo Life Sciences 产品网页

文章摘录数: 4

参考文献
Lai Y, Li J, Li X, Zou C. Lipopolysaccharide modulates p300 and Sirt1 to promote PRMT1 stability via an SCFFbxl17-recognized acetyldegron. J Cell Sci. 2017;130:3578-3587 pubmed 出版商
Liu Y, Lear T, Iannone O, Shiva S, Corey C, Rajbhandari S, et al. The Proapoptotic F-box Protein Fbxl7 Regulates Mitochondrial Function by Mediating the Ubiquitylation and Proteasomal Degradation of Survivin. J Biol Chem. 2015;290:11843-52 pubmed 出版商
Liu Y, Lear T, Zhao Y, Zhao J, Zou C, Chen B, et al. F-box protein Fbxl18 mediates polyubiquitylation and proteasomal degradation of the pro-apoptotic SCF subunit Fbxl7. Cell Death Dis. 2015;6:e1630 pubmed 出版商
Shaeffer J, Cohen R. Differential effects of ubiquitin aldehyde on ubiquitin and ATP-dependent protein degradation. Biochemistry. 1996;35:10886-93 pubmed

产品信息

产品编号 :

BML-UW8450

目录代码 :

BML-UW8450-0050

产品名称 :

泛肽醛,(重组)

产品类型 :

蛋白

规格 :

50微克

Pubmed号列表 :

25778398, 25654763, 8718881

产品描述 :

Synthetically modified recombinant ubiquitin. The modification of the C-terminal glycine carboxyl into an aldehyde results in a potent, highly specific inhibitor of all ubiquitin deconjugating enzymes, including ubiquitin C-terminal hydrolases (UCHs), ubiquitin-specific proteases (USPs) and deubiquitinylating enzymes (DUBs).

别名 :

Ub-H

纯度 :

≥95%(HPLC)

缓冲液 :

Liquid. In aqueous solution containing 0.15M HCl.

用途 :

Ubiquitin Aldehyde (recombinant) is useful in the stabilisation of ubiquitin-protein conjugates in vitro, enhancing their accumulation in cell lysates and tissue extracts. Inhibition of deubiquitinylating enzyme activity by Ubiquitin Aldehyde (recombinant) can be used to identify and confirm such activity and to determine the inhibition kinetics for a particular enzyme. Recommended concentration for maximal inhibition is 2-5µM. Co-crystallisation of ubiquitin aldehyde with specific deubiquitinylating enzymes (the inhibitor mimics the natural ubiquitin substrate) has also been used to probe enzyme:substrate interactions.

储存 :

+4°C

更多信息或购买 :

Enzo Life Sciences 产品网页

公司信息

Enzo Life Sciences

5777 Hines Drive
Ann Arbor, MI 48108

techserv-usa@enzolifesciences.com

https://www.enzolifesciences.com

1-800-942-0430

公司总部: 美国

自2007年始，Enzo Life Sciences先后合并ALEXIS Biochemicals、BIOMOL International等公司，为生命科学研究各个领域提供更全面的试剂产品。比如，肿瘤、细胞死亡、表观遗传、基因组学、免疫学、神经科学、信号转导及泛素和蛋白酶体等领域研究，都可以在Enzo Life Sciences中找到相应抗体、酶、蛋白、小分子抑制剂、产品文库及检测kit等产品。