Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

蛋白

IκBα (human), (recombinant) (untagged)

BML-UW9975-0050

50微克

BML-UW9975-0050

IκBα (human), (recombinant) (untagged)

蛋白

50微克

IκBa inhibits activation of the NF-κB pathway activation by associating with the major NF-κB heterodimeric complex p50/p65 and preventing its translocation from the cytoplasm into the nucleus, where it acts a transcription factor for genes involved in inflammation, autoimmune response, cell proliferation, and apoptosis. Inhibition of NF-κB pathway activation by IκBα is controlled by its sequential serine-phosphorylation, ubiquitination and proteasomal degradation. This process itself can be inhibited by SUMOylation of IκBα, providing an additional regulatory step for the activation of the NF-κB pathway.

液体。 在50mM羟乙基哌嗪乙磺酸, pH值7.5, 含200mM氯化钠和1mM DTT

Uses:. 1. NF-κB pathway studies, inhibition of NF-κB p50/p65, substrate for IκB kinase (IKK). 2.Investigation of IκBα phosphorylation/ubiquitinylation/SUMOylation. 3. Ubiquitin-proteasome mediated degradation studies.

-80°C