产品简要
公司名称 :
Enzo Life Sciences
其他品牌 :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
产品类型 :
蛋白
产品名称 :
NF-κB p65 subunit (human) (12-317), (recombinant) (untagged)
目录 :
BML-UW9995-0050
规格 :
50微克
更多信息或购买 :
产品信息
产品编号 :
BML-UW9995
目录代码 :
BML-UW9995-0050
产品名称 :
NF-κB p65 subunit (human) (12-317), (recombinant) (untagged)
产品类型 :
蛋白
规格 :
50微克
背景 :
The eukaryotic nuclear factor κB (NF-κB) plays an important role in inflammation, autoimmune response, cell proliferation, and apoptosis by regulating the expression of genes involved in these processes. Misregulation of the NF-κB signal transduction pathway is observed in a variety of human cancers, especially those of lymphoid cell origin. The prototypical inducible NF-κB is a heterodimeric complex consisting of p50 and p65, which normally exists in the cytoplasm of the cell as an inactive form due to association with its major inhibitory protein, IκBα. IκBα prevents the transport of NF-κB into the nucleus by masking its nuclear localization signal. Activation of NF-κB by extracellular inducers depends on the phosphorylation and subsequent degradation of IκBα by the ubiquitin-proteasome pathway. p65 subunit. The NF-κB p65 subunit is usually thought of as conferring the activation function of the NF-κB complex, though its capacity to associate with κB DNA in the absence of p50 and its potential utility as an independent transcription factor have also been demonstrated.
纯度 :
≥90%(十二烷基磺酸钠-PAGE)
缓冲液 :
Liquid. In 1X Dulbecco's Phosphate Buffered Saline (DPBS), pH 7.4, containing 5% glycerol.
用途 :
For NF-κB pathway studies.
储存 :
-80°C
更多信息或购买 :
公司信息
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
techserv-usa@enzolifesciences.com
https://www.enzolifesciences.com
1-800-942-0430
公司总部: 美国
自2007年始,Enzo Life Sciences先后合并ALEXIS Biochemicals、BIOMOL International等公司,为生命科学研究各个领域提供更全面的试剂产品。比如,肿瘤、细胞死亡、表观遗传、基因组学、免疫学、神经科学、信号转导及泛素和蛋白酶体等领域研究,都可以在Enzo Life Sciences中找到相应抗体、酶、蛋白、小分子抑制剂、产品文库及检测kit等产品。