产品简要
公司名称 :
GeneTex
产品类型 :
抗体
产品名称 :
Rad51抗体[N1C2]
目录 :
GTX100469
克隆性 :
多克隆
宿主 :
兔
共轭标签 :
未共轭
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 免疫组化, 染色质免疫沉淀
更多信息或购买 :
GeneTex 产品网页
文章摘录数: 10
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 小鼠; 1:500; 图 s7i
Kanakkanthara A, Jeganathan K, Limzerwala J, Baker D, Hamada M, Nam H, et al. Cyclin A2 is an RNA binding protein that controls Mre11 mRNA translation. Science. 2016;353:1549-1552 pubmed
  • 染色质免疫沉淀 ; 人类; 图 4c
  • 免疫印迹; 人类; 图 S7d
Chakraborty A, Tapryal N, Venkova T, Horikoshi N, Pandita R, Sarker A, et al. Classical non-homologous end-joining pathway utilizes nascent RNA for error-free double-strand break repair of transcribed genes. Nat Commun. 2016;7:13049 pubmed 出版商
  • 免疫组化; 人类; 图 7
Ge C, Che L, Du C. The UBC Domain Is Required for BRUCE to Promote BRIT1/MCPH1 Function in DSB Signaling and Repair Post Formation of BRUCE-USP8-BRIT1 Complex. PLoS ONE. 2015;10:e0144957 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000
Kim T, Ko J, Hu L, Kim S, Bishop A, Vijg J, et al. RAD51 mutants cause replication defects and chromosomal instability. Mol Cell Biol. 2012;32:3663-80 pubmed 出版商
Peng Y, Liao Q, Tan W, Peng C, Hu Z, Chen Y, et al. The deubiquitylating enzyme USP15 regulates homologous recombination repair and cancer cell response to PARP inhibitors. Nat Commun. 2019;10:1224 pubmed 出版商
Li Y, Luo K, Yin Y, Wu C, Deng M, Li L, et al. USP13 regulates the RAP80-BRCA1 complex dependent DNA damage response. Nat Commun. 2017;8:15752 pubmed 出版商
Hong K, Hsu M, Hung W. RECK impedes DNA repair by inhibiting the erbB/JAB1/Rad51 signaling axis and enhances chemosensitivity of breast cancer cells. Am J Cancer Res. 2015;5:2422-30 pubmed
Ge C, Che L, Ren J, Pandita R, Lu J, Li K, et al. BRUCE regulates DNA double-strand break response by promoting USP8 deubiquitination of BRIT1. Proc Natl Acad Sci U S A. 2015;112:E1210-9 pubmed 出版商
Ohba S, Mukherjee J, See W, Pieper R. Mutant IDH1-driven cellular transformation increases RAD51-mediated homologous recombination and temozolomide resistance. Cancer Res. 2014;74:4836-44 pubmed 出版商
Park J, Huang S, Tougeron D, Sinicrope F. MSH3 mismatch repair protein regulates sensitivity to cytotoxic drugs and a histone deacetylase inhibitor in human colon carcinoma cells. PLoS ONE. 2013;8:e65369 pubmed 出版商
产品信息
目录代码 :
GTX100469
产品名称 :
Rad51抗体[N1C2]
宿主物种 :
兔
克隆性 :
多克隆
产品类型 :
一抗
Pubmed号列表 :
22778135,23724141,25035396,26683461,25733871,27703167,26396917,28569838,28569838
背景 :
The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. Transcript variants utilizing alternative polyA signals exist. [provided by RefSeq]
更多信息或购买 :
GeneTex 产品网页
公司信息
GeneTex
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Irvine, CA92606
support@genetex.com
http://www.genetex.com
886-3-6208988
公司总部: 美国