产品简要
公司名称 :
GeneTex
产品类型 :
抗体
产品名称 :
TDG抗体
目录 :
GTX110473
克隆性 :
多克隆
宿主 :
兔
共轭标签 :
nonconjugated
反应物种 :
人类
应用 :
免疫印迹
更多信息或购买 :
GeneTex 产品网页
文章摘录数: 4
出版应用/物种/样品/稀释参考文献
  • 免疫印迹; 人类; 1:2000; 图 1d
McLaughlin D, Coey C, Yang W, Drohat A, Matunis M. Characterizing Requirements for Small Ubiquitin-like Modifier (SUMO) Modification and Binding on Base Excision Repair Activity of Thymine-DNA Glycosylase in Vivo. J Biol Chem. 2016;291:9014-24 pubmed 出版商
Jin C, Qin T, Barton M, Jelinek J, Issa J. Minimal role of base excision repair in TET-induced global DNA demethylation in HEK293T cells. Epigenetics. 2015;10:1006-13 pubmed 出版商
Moriyama T, Fujimitsu Y, Yoshikai Y, Sasano T, Yamada K, Murakami M, et al. SUMO-modification and elimination of the active DNA demethylation enzyme TDG in cultured human cells. Biochem Biophys Res Commun. 2014;447:419-24 pubmed 出版商
Xu X, Yu T, Shi J, Chen X, Zhang W, Lin T, et al. Thymine DNA glycosylase is a positive regulator of Wnt signaling in colorectal cancer. J Biol Chem. 2014;289:8881-90 pubmed 出版商
产品信息
目录代码 :
GTX110473
产品名称 :
TDG抗体
宿主物种 :
兔
克隆性 :
多克隆
产品类型 :
一抗
Pubmed号列表 :
24727457,24532795,26917720,26440216
背景 :
The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12. [provided by RefSeq]
更多信息或购买 :
GeneTex 产品网页
公司信息
GeneTex
2456 Alton Pkwy
Irvine, CA92606
support@genetex.com
www.genetex.com
886-3-6208988
公司总部: 美国