产品简要
公司名称 :
GeneTex
产品类型 :
抗体
产品名称 :
p38 MAPK抗体[N1C3-2]
目录 :
GTX110720
克隆性 :
多克隆
宿主 :
兔
共轭标签 :
nonconjugated
反应物种 :
人类
更多信息或购买 :
文章摘录数: 8
参考文献 |
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产品信息
目录代码 :
GTX110720
产品名称 :
p38 MAPK抗体[N1C3-2]
宿主物种 :
兔
克隆性 :
多克隆
产品类型 :
一抗
Pubmed号列表 :
23664097,24083466,27487563,27414646,26317424,29142215,29518977,28232982
背景 :
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq]
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GeneTex
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