产品简要
公司名称 :
GeneTex
产品类型 :
抗体
产品名称 :
p21 Cip1抗体
目录 :
GTX112898
克隆性 :
多克隆
宿主 :
兔
共轭标签 :
未共轭
反应物种 :
人类
更多信息或购买 :
GeneTex 产品网页
文章摘录数: 4
参考文献
Abdalla B, Li Z, Ouyang H, Jebessa E, Sun T, Yu J, et al. A Novel Dnmt3a1 Transcript Inhibits Adipogenesis. Front Physiol. 2018;9:1270 pubmed 出版商
Cai B, Ma M, Chen B, Li Z, Abdalla B, Nie Q, et al. MiR-16-5p targets SESN1 to regulate the p53 signaling pathway, affecting myoblast proliferation and apoptosis, and is involved in myoblast differentiation. Cell Death Dis. 2018;9:367 pubmed 出版商
Lee W, Lee W, Cheng C, Chen K, Chou C, Chung C, et al. Repositioning antipsychotic chlorpromazine for treating colorectal cancer by inhibiting sirtuin 1. Oncotarget. 2015;6:27580-95 pubmed 出版商
Ma G, Wang H, Gu X, Li W, Zhang X, Cui L, et al. CARP, a myostatin-downregulated gene in CFM Cells, is a novel essential positive regulator of myogenesis. Int J Biol Sci. 2014;10:309-20 pubmed 出版商
产品信息
目录代码 :
GTX112898
产品名称 :
p21 Cip1抗体
宿主物种 :
兔
克隆性 :
多克隆
产品类型 :
一抗
Pubmed号列表 :
24644428,26363315,29511169
背景 :
This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Two alternatively spliced variants, which encode an identical protein, have been reported. [provided by RefSeq]
更多信息或购买 :
GeneTex 产品网页
公司信息
GeneTex
2456 Alton Pkwy
Irvine, CA92606
support@genetex.com
http://www.genetex.com
886-3-6208988
公司总部: 美国