产品简要
公司名称 :
GeneTex
产品类型 :
抗体
产品名称 :
组蛋白H3K9ac(乙酰Lys9)抗体[AH3-120]
目录 :
GTX12179
规格 :
50.00μl
价格 :
289美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
nonconjugated
抗原修饰 :
乙酰化
克隆名称 :
AH3-120
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学
更多信息或购买 :
文章摘录数: 1
产品信息
目录号 :
GTX12179
产品名称 :
组蛋白H3K9ac(乙酰Lys9)抗体[AH3-120]
宿主物种 :
小鼠
克隆性 :
单克隆
抗原修饰 :
乙酰化
产品类型 :
一抗
规格 :
50.00μl
标价 :
289美元
Pubmed号列表 :
18614164
克隆 :
AH3-120
抗体亚型 :
IgG1
产品描述 :
Mouse monoclonal [AH3 - 120] to Histone H3 ( acetyl K9 )
交叉活性 :
Hu, Ms, Dm, Rat
背景 :
Histone proteins H3, H4, H2A, and H2B function as building blocks to package eukaryotic DNA into repeating nucleosome units that are folded in higher order chromatin fibers. The nucleosome is composed of an octamer containing a H3/H4 tetramer and two H2A/H2B dimers, surrounded by approximately 146 base pairs of DNA. A diverse and elaborate array of post-translational modifications including acetylation, phosphorylation, methylation, ubiquitination, and ADP-ribosylation occurs on the N-terminal tail domains of histones. Acetylation of lysine residues within these N-terminal domains by histone acetyl-transferases (HATs), including Gcn5p, P/CAF, p300/CBP, and TAFII250, is associated with transcriptional activation. This modification results in remodeling of the nucleosome structure into an open conformation more accessible to transcription complexes. Conversely, histone deacetylation by histone deacetylases (HDACs) is associated with transcription repression reversing the chromatin remodeling process. In most species, histone H3 is primarily acetylated at lysine 9, 14, 18, and 23. Acetylation at lysine 9 appears to have a dominant role in histone deposition and chromatin assembly in some organisms.
免疫原 :
A synthetic, acetylated histone H3 peptide (amino acids 7-20, acetyl K9) corresponding to the N-terminus of human histone H3, conjugated to KLH.
特异性 :
Staining of (acetyl K9) histone H3 in immunoblotting is specifically inhibited with the immunizing peptide. There is no inhibition with non-acetylated histone H3 peptide.
缓冲液 :
Preservative: 15mM Sodium Azide; Constituents: 0.01M PBS. pH 7.4
用途 :
酶联免疫吸附测定, 免疫细胞化学/IF, 免疫组化, 免疫印迹
浓度 :
2.1毫克/毫升
一般参考 :
Keep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles.
更多信息或购买 :
公司信息
GeneTex