产品简要
公司名称 :
GeneTex
产品类型 :
抗体
产品名称 :
ERK1/2抗体
目录 :
GTX17942
规格 :
50.00μl
价格 :
299美元
克隆性 :
多克隆
宿主 :
共轭标签 :
nonconjugated
反应物种 :
人类, 小鼠, 大鼠,
应用 :
免疫印迹
更多信息或购买 :
文章摘录数: 3
出版应用/物种/样品/稀释参考文献
  • 免疫印迹; 人类; 图 1b
Caporali S, Alvino E, Lacal P, Levati L, Giurato G, Memoli D, et al. Targeting the PI3K/AKT/mTOR pathway overcomes the stimulating effect of dabrafenib on the invasive behavior of melanoma cells with acquired resistance to the BRAF inhibitor. Int J Oncol. 2016;49:1164-74 pubmed 出版商
  • 免疫印迹; 人类; 1:1000
Graziani G, Artuso S, De Luca A, Muzi A, Rotili D, Scimeca M, et al. A new water soluble MAPK activator exerts antitumor activity in melanoma cells resistant to the BRAF inhibitor vemurafenib. Biochem Pharmacol. 2015;95:16-27 pubmed 出版商
Geng F, Cheng X, Wu X, Yoo J, Cheng C, Guo J, et al. Inhibition of SOAT1 Suppresses Glioblastoma Growth via Blocking SREBP-1-Mediated Lipogenesis. Clin Cancer Res. 2016;22:5337-5348 pubmed
产品信息
目录号 :
GTX17942
产品名称 :
ERK1/2抗体
宿主物种 :
克隆性 :
多克隆
产品类型 :
一抗
规格 :
50.00μl
标价 :
299美元
Pubmed号列表 :
25795251
抗体亚型 :
IgG
产品描述 :
兔多克隆抗体ERK1/2
交叉活性 :
Hu, Ms, Cow, Rat
背景 :
ERK (extracellular signal regulated kinase), also known as MAPK (mitogen-activated protein kinase) has two closely related isoforms of 44 kDa and 42 kDa, respectively. These kinases belong to a family of serine/threonine kinases that are activated upon treatment of cells with a large variety of stimuli including mitogens, hormones, growth factors, cytokines, and bioactive peptides. Cell stimulation induces the activation of a signaling cascade, the downstream effects of which have been linked to the regulation of cell growth and differentiation as well as the cytoskeleton. ERK1 and ERK2 are phosphorylated within the activation loop on both a Threonine and a Tyrosine residue (within a Thr-Glu-Tyr motif) by MEKs (MAPK/ERK kinases), thereby greatly elevating the activity of ERK1&2.
免疫原 :
Synthetic peptide, corresponding to C terminal amino acids 317-339 of Human ERK1 + ERK2.
缓冲液 :
Preservative: 0.05% Sodium Azide. Constituents: 50% Glycerol, PBS, 1mg/ml BSA. pH 7.3
用途 :
免疫印迹
一般参考 :
Keep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles.
更多信息或购买 :
公司信息
GeneTex
2456 Alton Pkwy
Irvine, CA92606
support@genetex.com
www.genetex.com
886-3-6208988
公司总部: 美国