产品简要
公司名称 :
GeneTex
产品类型 :
抗体
产品名称 :
p21 Cip1抗体
目录 :
GTX27960
规格 :
1.00毫升
价格 :
299美元
克隆性 :
多克隆
宿主 :
兔
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫沉淀, 免疫组化-冰冻切片
更多信息或购买 :
文章摘录数: 3
| 出版应用/物种/样本/稀释 | 参考文献 |
|---|---|
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产品信息
目录号 :
GTX27960
产品名称 :
p21 Cip1抗体
宿主物种 :
兔
克隆性 :
多克隆
产品类型 :
一抗
规格 :
1.00毫升
标价 :
299美元
Pubmed号列表 :
24763901
抗体亚型 :
IgG
产品描述 :
兔多克隆抗体p21 Cip1
交叉活性 :
Hu, Ms, Rat
背景 :
Cell cycle progression is regulated by cyclins and their cognate Cdks (1-3). p21 (WAF1/Cip1) inhibits the activity of each member of the cyclin/Cdk family and over expression of this protein inhibits the proliferation of mammalian cells (5). The expression of p21 is inducible by a wide range of stress stimuli and its transcription can be enhanced by p53 (6). Another member of the CDIs is p27 (also known as Kip1), which also sees up regulation in response to antimitogenic stimuli (7). The increased protein expression of p27 results in cellular arrest by binding to cyclin/Cdk complexes, like cyclin D1/Cdk4 (4,8). An additional CDI has been found to bind Cdk4 and Cdk6, p16 (INK4A), and when such complexes are formed, the progression of the cell cycle is halted (9). It has become increasingly clear that p16 is a very important tumor suppressor gene whose frequent loss occurs early in many human cancers. p16 is a major target in carcinogenesis that is rivaled in frequency only by p53 (10).
免疫原 :
合成肽(人类)(C末端)
特异性 :
Reacts with p21(also designated WAF1/Cip1)
缓冲液 :
PBS含0.1％叠氮化钠
用途 :
IHC-Fr, IP, WB
浓度 :
0.2毫克/毫升
一般参考 :
Store this product at 4 °C, do not freeze. The product is stable for one year from the date of shipment.
更多信息或购买 :
公司信息
GeneTex