产品简要
公司名称 :
GeneTex
产品类型 :
抗体
产品名称 :
MMP14抗体[EP1264Y]
目录 :
GTX61603
规格 :
100.00μl
价格 :
329美元
克隆性 :
单克隆
宿主 :
兔
共轭标签 :
未共轭
克隆名称 :
EP1264Y
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 免疫组化-石蜡切片
更多信息或购买 :
GeneTex 产品网页
文章摘录数: 4
出版应用/物种/样本/稀释参考文献
  • 免疫组化-石蜡切片; 人类; 1:200; 表 2
Cid S, Eiró N, Gonzalez L, Béridze N, Vazquez J, Vizoso F. Expression and Clinical Significance of Metalloproteases and Their Inhibitors by Endothelial Cells From Invasive Breast Carcinomas. Clin Breast Cancer. 2016;16:e83-91 pubmed 出版商
Nakazawa Y, Taniyama Y, Sanada F, Morishita R, Nakamori S, Morimoto K, et al. Periostin blockade overcomes chemoresistance via restricting the expansion of mesenchymal tumor subpopulations in breast cancer. Sci Rep. 2018;8:4013 pubmed 出版商
Sandner A, Illert J, Koitzsch S, Unverzagt S, Schön I. Reflux induces DNA strand breaks and expression changes of MMP1+9+14 in a human miniorgan culture model. Exp Cell Res. 2013;319:2905-15 pubmed 出版商
Kudo L, Parfenova L, Vi N, Lau K, Pomakian J, Valdmanis P, et al. Integrative gene-tissue microarray-based approach for identification of human disease biomarkers: application to amyotrophic lateral sclerosis. Hum Mol Genet. 2010;19:3233-53 pubmed 出版商
产品信息
目录号 :
GTX61603
产品名称 :
MMP14抗体[EP1264Y]
宿主物种 :
兔
克隆性 :
单克隆
产品类型 :
一抗
规格 :
100.00μl
标价 :
329美元
Pubmed号列表 :
20530642,24075964
克隆 :
EP1264Y
抗体亚型 :
IgG
产品描述 :
Rabbit monoclonal antibody [EP1264Y] to MMP-14
交叉活性 :
Hu, Ms, Rat
背景 :
The matrix metalloproteinase (MMP) family (approximately 25 members in mammals) has been implicated in extracellular matrix remodeling associated with embryonic development, cancer formation and progression, and various other physiological and pathological events. MMP-14 is a membrane-bound matrix metalloproteinase (MT-MMP) capable of mediating pericellular proteolysis of extracellular matrix components. MMP-14 is therefore thought to be an important molecular tool for cellular remodeling of the surrounding matrix . Gelatinase A (type-IV collagenase; M(r) 72,000) is produced by tumor stroma cells and is believed to be crucial for their invasion and metastasis, acting by degrading extracellular matrix macro-molecules such as type IV collagen. MMP-14 may thus trigger invasion by tumor cells by activating pro-gelatinase A on the tumor cell surface . Observations identify MT1-MMP as a tumor-derived growth factor that regulates proliferation by controlling cell geometry within the confines of the 3D extracellular matrix (ECM) .
免疫原 :
It is raised against a short peptide, which maps between amino acids 160~190 of human MMP-14 (Uniprot:P50281).
缓冲液 :
50 mM三羟甲基氨基甲烷甘氨酸(pH值7.4), 0.15 M氯化钠, 40% 甘油, 0.01% 叠氮化钠和0.05% BSA
用途 :
流式细胞仪, 免疫细胞化学/IF, 免疫组化-P, 免疫沉淀, 免疫印迹
一般参考 :
Store at -20 °C. Stable for 12 months from date of receipt.
更多信息或购买 :
GeneTex 产品网页
公司信息
GeneTex
2456 Alton Pkwy
Irvine, CA92606
support@genetex.com
http://www.genetex.com
886-3-6208988
公司总部: 美国