产品简要
公司名称 :
GeneTex
产品类型 :
抗体
产品名称 :
毛细血管扩张性共济失调症突变蛋白(磷酸化Ser1981)抗体[EP1890Y]
目录 :
GTX61739
规格 :
100.00μl
价格 :
329美元
克隆性 :
单克隆
宿主 :
兔
共轭标签 :
未共轭
抗原修饰 :
磷酸化
克隆名称 :
EP1890Y
反应物种 :
人类
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 免疫组化-石蜡切片
更多信息或购买 :
GeneTex 产品网页
文章摘录数: 6
出版应用/物种/样本/稀释参考文献
  • 免疫细胞化学; 人类; 1:1000; 图 1b
Chen C, Tsao N, Huang L, Yen Y, Liu X, Lehman C, et al. The Impact of dUTPase on Ribonucleotide Reductase-Induced Genome Instability in Cancer Cells. Cell Rep. 2016;16:1287-1299 pubmed 出版商
  • 免疫印迹; 人类; 图 6
Cekan P, Hasegawa K, Pan Y, Tubman E, Odde D, Chen J, et al. RCC1-dependent activation of Ran accelerates cell cycle and DNA repair, inhibiting DNA damage-induced cell senescence. Mol Biol Cell. 2016;27:1346-57 pubmed 出版商
  • 免疫印迹; 人类
Li L, Wu P, Lee J, Li P, Hsieh W, Ho C, et al. Hinokitiol induces DNA damage and autophagy followed by cell cycle arrest and senescence in gefitinib-resistant lung adenocarcinoma cells. PLoS ONE. 2014;9:e104203 pubmed 出版商
Jones G, Rooney C, Griffin N, Roudier M, Young L, Garcia Trinidad A, et al. pRAD50: a novel and clinically applicable pharmacodynamic biomarker of both ATM and ATR inhibition identified using mass spectrometry and immunohistochemistry. Br J Cancer. 2018;119:1233-1243 pubmed 出版商
Cheung C, Singh R, Kalra R, Kaul S, Wadhwa R. Collaborator of ARF (CARF) regulates proliferative fate of human cells by dose-dependent regulation of DNA damage signaling. J Biol Chem. 2014;289:18258-69 pubmed 出版商
Huang F, Chang C, Wang J, Chang T, Lin J. Induction of senescence in cancer cells by the G-quadruplex stabilizer, BMVC4, is independent of its telomerase inhibitory activity. Br J Pharmacol. 2012;167:393-406 pubmed 出版商
产品信息
目录号 :
GTX61739
产品名称 :
毛细血管扩张性共济失调症突变蛋白(磷酸化Ser1981)抗体[EP1890Y]
宿主物种 :
兔
克隆性 :
单克隆
抗原修饰 :
磷酸化
产品类型 :
一抗
规格 :
100.00μl
标价 :
329美元
Pubmed号列表 :
22509942,24825908,25105411
克隆 :
EP1890Y
抗体亚型 :
IgG
产品描述 :
Rabbit monoclonal antibody [EP1890Y] to ATM (phospho Ser1981)
交叉活性 :
Hu
背景 :
The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq, Aug 2010]
免疫原 :
A synthetic peptide corresponding to residues surrounding serine 1981 of human ATM was used as an immunogen.
缓冲液 :
PBS含50% 甘油, 0.05% BSA和0.01% 叠氮化钠
用途 :
免疫细胞化学/IF, 免疫组化, 免疫组化-P, 免疫沉淀, 免疫印迹
一般参考 :
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
更多信息或购买 :
GeneTex 产品网页
公司信息
GeneTex
2456 Alton Pkwy
Irvine, CA92606
support@genetex.com
http://www.genetex.com
886-3-6208988
公司总部: 美国