产品简要
公司名称 :
GeneTex
产品类型 :
抗体
产品名称 :
p21 Cip1抗体[GT1032]
目录 :
GTX629543
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
nonconjugated
克隆名称 :
GT1032
反应物种 :
人类
更多信息或购买 :
GeneTex 产品网页
文章摘录数: 3
参考文献
Hsu K, Huang C, Tam K, Lin C, Huang L, Lin C, et al. The Application of Non-Invasive Apoptosis Detection Sensor (NIADS) on Histone Deacetylation Inhibitor (HDACi)-Induced Breast Cancer Cell Death. Int J Mol Sci. 2018;19: pubmed 出版商
Chung C, Leung K, Lu W, Yen T, He C, Sheu J, et al. Hinokitiol Negatively Regulates Immune Responses through Cell Cycle Arrest in Concanavalin A-Activated Lymphocytes. Evid Based Complement Alternat Med. 2015;2015:595824 pubmed 出版商
Chang T, Hsu M, Wu K. High glucose induces bone marrow-derived mesenchymal stem cell senescence by upregulating autophagy. PLoS ONE. 2015;10:e0126537 pubmed 出版商
产品信息
目录代码 :
GTX629543
产品名称 :
p21 Cip1抗体[GT1032]
宿主物种 :
小鼠
克隆性 :
单克隆
产品类型 :
一抗
Pubmed号列表 :
26379747,25961745
背景 :
This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Two alternatively spliced variants, which encode an identical protein, have been reported. [provided by RefSeq]
更多信息或购买 :
GeneTex 产品网页
公司信息
GeneTex
2456 Alton Pkwy
Irvine, CA92606
support@genetex.com
www.genetex.com
886-3-6208988
公司总部: 美国