产品简要
公司名称 :
GeneTex
产品类型 :
抗体
产品名称 :
毛细血管扩张性共济失调症突变蛋白抗体[2C1]
目录 :
GTX70103
规格 :
100.00μg
价格 :
299美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
2C1
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 免疫组化-石蜡切片
更多信息或购买 :
GeneTex 产品网页
文章摘录数: 171
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 人类; 1:500; 图 1f
Li F, Liu J, Bao R, Yan G, Feng X, Xu Y, et al. Acetylation accumulates PFKFB3 in cytoplasm to promote glycolysis and protects cells from cisplatin-induced apoptosis. Nat Commun. 2018;9:508 pubmed 出版商
  • 免疫印迹; 人类; 图 s2e
Clarke T, Sanchez Bailon M, Chiang K, Reynolds J, Herrero Ruiz J, Bandeiras T, et al. PRMT5-Dependent Methylation of the TIP60 Coactivator RUVBL1 Is a Key Regulator of Homologous Recombination. Mol Cell. 2017;65:900-916.e7 pubmed 出版商
  • 免疫印迹; 小鼠; 图 3
He D, Xiang J, Li B, Liu H. The dynamic behavior of Ect2 in response to DNA damage. Sci Rep. 2016;6:24504 pubmed 出版商
  • 免疫沉淀; 人类; 图 4
Salzman D, Nakamura K, Nallur S, Dookwah M, Metheetrairut C, Slack F, et al. miR-34 activity is modulated through 5'-end phosphorylation in response to DNA damage. Nat Commun. 2016;7:10954 pubmed 出版商
  • 免疫印迹; 人类; 图 5
Wang Y, Xu Q, Sack L, Kang C, Elledge S. A gain-of-function senescence bypass screen identifies the homeobox transcription factor DLX2 as a regulator of ATM-p53 signaling. Genes Dev. 2016;30:293-306 pubmed 出版商
  • 免疫印迹; 人类; 图 1
Kuo C, Li X, Stark J, Shih H, Ann D. RNF4 regulates DNA double-strand break repair in a cell cycle-dependent manner. Cell Cycle. 2016;15:787-98 pubmed 出版商
  • 免疫细胞化学; 人类; 图 2
  • 免疫印迹; 人类; 图 4
Chou W, Hu L, Hsiung C, Shen C. Initiation of the ATM-Chk2 DNA damage response through the base excision repair pathway. Carcinogenesis. 2015;36:832-40 pubmed 出版商
  • 免疫印迹; 人类; 图 5
Nakajima N, Hagiwara Y, Oike T, Okayasu R, Murakami T, Nakano T, et al. Pre-exposure to ionizing radiation stimulates DNA double strand break end resection, promoting the use of homologous recombination repair. PLoS ONE. 2015;10:e0122582 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 5b
Kumari A, Owen N, Juarez E, McCullough A. BLM protein mitigates formaldehyde-induced genomic instability. DNA Repair (Amst). 2015;28:73-82 pubmed 出版商
  • 免疫印迹; 小鼠; 图 7a
Ruan X, Zuo Q, Jia H, Chau J, Lin J, Ao J, et al. P53 deficiency-induced Smad1 upregulation suppresses tumorigenesis and causes chemoresistance in colorectal cancers. J Mol Cell Biol. 2015;7:105-18 pubmed 出版商
  • 免疫印迹; 人类; 图 s5
Zellweger R, Dalcher D, Mutreja K, Berti M, Schmid J, Herrador R, et al. Rad51-mediated replication fork reversal is a global response to genotoxic treatments in human cells. J Cell Biol. 2015;208:563-79 pubmed 出版商
  • 免疫组化; 人类; 图 1
Gibbs Seymour I, Markiewicz E, Bekker Jensen S, Mailand N, Hutchison C. Lamin A/C-dependent interaction with 53BP1 promotes cellular responses to DNA damage. Aging Cell. 2015;14:162-9 pubmed 出版商
  • 免疫印迹; 人类; 图 6
Ray Chaudhuri A, Ahuja A, Herrador R, Lopes M. Poly(ADP-ribosyl) glycohydrolase prevents the accumulation of unusual replication structures during unperturbed S phase. Mol Cell Biol. 2015;35:856-65 pubmed 出版商
  • 免疫印迹; 人类; 图 3
Hühn D, Kousholt A, Sørensen C, Sartori A. miR-19, a component of the oncogenic miR-17∼92 cluster, targets the DNA-end resection factor CtIP. Oncogene. 2015;34:3977-84 pubmed 出版商
  • 免疫印迹; 人类
Li L, Wu P, Lee J, Li P, Hsieh W, Ho C, et al. Hinokitiol induces DNA damage and autophagy followed by cell cycle arrest and senescence in gefitinib-resistant lung adenocarcinoma cells. PLoS ONE. 2014;9:e104203 pubmed 出版商
  • 免疫印迹; 人类; 图 s2
Shibata A, Moiani D, Arvai A, Perry J, Harding S, Genois M, et al. DNA double-strand break repair pathway choice is directed by distinct MRE11 nuclease activities. Mol Cell. 2014;53:7-18 pubmed 出版商
  • 免疫印迹; 小鼠; 1:500
Hardee M, Marciscano A, Medina Ramirez C, Zagzag D, Narayana A, Lonning S, et al. Resistance of glioblastoma-initiating cells to radiation mediated by the tumor microenvironment can be abolished by inhibiting transforming growth factor-?. Cancer Res. 2012;72:4119-29 pubmed 出版商
  • 免疫印迹; 人类
Guo Z, Deshpande R, Paull T. ATM activation in the presence of oxidative stress. Cell Cycle. 2010;9:4805-11 pubmed
  • 免疫印迹; 人类; 图 5
Sakasai R, Teraoka H, Takagi M, Tibbetts R. Transcription-dependent activation of ataxia telangiectasia mutated prevents DNA-dependent protein kinase-mediated cell death in response to topoisomerase I poison. J Biol Chem. 2010;285:15201-8 pubmed 出版商
  • 免疫印迹; 人类; 图 2
Sakasai R, Teraoka H, Tibbetts R. Proteasome inhibition suppresses DNA-dependent protein kinase activation caused by camptothecin. DNA Repair (Amst). 2010;9:76-82 pubmed 出版商
  • 免疫沉淀; 人类
  • 免疫印迹; 人类
Ariumi Y, Kuroki M, Dansako H, Abe K, Ikeda M, Wakita T, et al. The DNA damage sensors ataxia-telangiectasia mutated kinase and checkpoint kinase 2 are required for hepatitis C virus RNA replication. J Virol. 2008;82:9639-46 pubmed 出版商
  • 免疫印迹; 小鼠; 1:500
Yalcin S, Zhang X, Luciano J, Mungamuri S, Marinkovic D, Vercherat C, et al. Foxo3 is essential for the regulation of ataxia telangiectasia mutated and oxidative stress-mediated homeostasis of hematopoietic stem cells. J Biol Chem. 2008;283:25692-705 pubmed 出版商
  • 免疫印迹; 人类
Sakasai R, Tibbetts R. RNF8-dependent and RNF8-independent regulation of 53BP1 in response to DNA damage. J Biol Chem. 2008;283:13549-55 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000
Pusapati R, Rounbehler R, Hong S, Powers J, Yan M, Kiguchi K, et al. ATM promotes apoptosis and suppresses tumorigenesis in response to Myc. Proc Natl Acad Sci U S A. 2006;103:1446-51 pubmed
Yang Z, Shen Y, Oishi H, Matteson E, Tian L, Goronzy J, et al. Restoring oxidant signaling suppresses proarthritogenic T cell effector functions in rheumatoid arthritis. Sci Transl Med. 2016;8:331ra38 pubmed 出版商
Saquilabon Cruz G, Kong X, Silva B, Khatibzadeh N, Thai R, Berns M, et al. Femtosecond near-infrared laser microirradiation reveals a crucial role for PARP signaling on factor assemblies at DNA damage sites. Nucleic Acids Res. 2016;44:e27 pubmed 出版商
Zhang J, Tripathi D, Jing J, Alexander A, Kim J, Powell R, et al. ATM functions at the peroxisome to induce pexophagy in response to ROS. Nat Cell Biol. 2015;17:1259-1269 pubmed 出版商
Sajish M, Schimmel P. A human tRNA synthetase is a potent PARP1-activating effector target for resveratrol. Nature. 2015;519:370-3 pubmed 出版商
Du F, Zhang M, Li X, Yang C, Meng H, Wang D, et al. Dimer monomer transition and dimer re-formation play important role for ATM cellular function during DNA repair. Biochem Biophys Res Commun. 2014;452:1034-9 pubmed 出版商
Kotov I, Siebring van Olst E, Knobel P, van der Meulen Muileman I, Felley Bosco E, van Beusechem V, et al. Whole genome RNAi screens reveal a critical role of REV3 in coping with replication stress. Mol Oncol. 2014;8:1747-59 pubmed 出版商
Lee J, Guo Z, Myler L, Zheng S, Paull T. Direct activation of ATM by resveratrol under oxidizing conditions. PLoS ONE. 2014;9:e97969 pubmed 出版商
Hennig J, McShane M, Cordes N, Eke I. APPL proteins modulate DNA repair and radiation survival of pancreatic carcinoma cells by regulating ATM. Cell Death Dis. 2014;5:e1199 pubmed 出版商
Wang C, Huang E, Huang S, Chung B. DNA-PK/Chk2 induces centrosome amplification during prolonged replication stress. Oncogene. 2015;34:1263-9 pubmed 出版商
Sharma N, Lebedeva M, Thomas T, Kovalenko O, Stumpf J, Shadel G, et al. Intrinsic mitochondrial DNA repair defects in Ataxia Telangiectasia. DNA Repair (Amst). 2014;13:22-31 pubmed 出版商
Lim H, Xie L, Zhang W, Li R, Chen Z, Wu G, et al. Ribosomal S6 Kinase 2 (RSK2) maintains genomic stability by activating the Atm/p53-dependent DNA damage pathway. PLoS ONE. 2013;8:e74334 pubmed 出版商
Bowen C, Ju J, Lee J, Paull T, Gelmann E. Functional activation of ATM by the prostate cancer suppressor NKX3.1. Cell Rep. 2013;4:516-29 pubmed 出版商
Tripathi D, Chowdhury R, Trudel L, Tee A, Slack R, Walker C, et al. Reactive nitrogen species regulate autophagy through ATM-AMPK-TSC2-mediated suppression of mTORC1. Proc Natl Acad Sci U S A. 2013;110:E2950-7 pubmed 出版商
Zhang X, Jia D, Liu H, Zhu N, Zhang W, Feng J, et al. Identification of 5-Iodotubercidin as a genotoxic drug with anti-cancer potential. PLoS ONE. 2013;8:e62527 pubmed 出版商
Lee J, Mand M, Deshpande R, Kinoshita E, Yang S, Wyman C, et al. Ataxia telangiectasia-mutated (ATM) kinase activity is regulated by ATP-driven conformational changes in the Mre11/Rad50/Nbs1 (MRN) complex. J Biol Chem. 2013;288:12840-51 pubmed 出版商
Stewart R, Kozlov S, Matigian N, Wali G, Gatei M, Sutharsan R, et al. A patient-derived olfactory stem cell disease model for ataxia-telangiectasia. Hum Mol Genet. 2013;22:2495-509 pubmed 出版商
Wu C, Dong Y, Liang Q, He X, Ng S, Chan F, et al. MicroRNA-18a attenuates DNA damage repair through suppressing the expression of ataxia telangiectasia mutated in colorectal cancer. PLoS ONE. 2013;8:e57036 pubmed 出版商
Cottarel J, Frit P, Bombarde O, Salles B, Négrel A, Bernard S, et al. A noncatalytic function of the ligation complex during nonhomologous end joining. J Cell Biol. 2013;200:173-86 pubmed 出版商
Choi S, Jang H, Roe J, Kim S, Cho E, Youn H. Phosphorylation and ubiquitination-dependent degradation of CABIN1 releases p53 for transactivation upon genotoxic stress. Nucleic Acids Res. 2013;41:2180-90 pubmed 出版商
Shi Y, Felley Bosco E, Marti T, Orlowski K, Pruschy M, Stahel R. Starvation-induced activation of ATM/Chk2/p53 signaling sensitizes cancer cells to cisplatin. BMC Cancer. 2012;12:571 pubmed 出版商
Nayler S, Gatei M, Kozlov S, Gatti R, Mar J, Wells C, et al. Induced pluripotent stem cells from ataxia-telangiectasia recapitulate the cellular phenotype. Stem Cells Transl Med. 2012;1:523-35 pubmed 出版商
Murad N, Cullen J, McKenzie M, Ryan M, Thorburn D, Gueven N, et al. Mitochondrial dysfunction in a novel form of autosomal recessive ataxia. Mitochondrion. 2013;13:235-45 pubmed 出版商
Sakasai R, Sakai A, Iimori M, Kiyonari S, Matsuoka K, Kakeji Y, et al. CtIP- and ATR-dependent FANCJ phosphorylation in response to DNA strand breaks mediated by DNA replication. Genes Cells. 2012;17:962-70 pubmed 出版商
Shi Y, Felley Bosco E, Marti T, Stahel R. Differential effects of lovastatin on cisplatin responses in normal human mesothelial cells versus cancer cells: implication for therapy. PLoS ONE. 2012;7:e45354 pubmed 出版商
Baritaud M, Cabon L, Delavallée L, Galán Malo P, Gilles M, Brunelle Navas M, et al. AIF-mediated caspase-independent necroptosis requires ATM and DNA-PK-induced histone H2AX Ser139 phosphorylation. Cell Death Dis. 2012;3:e390 pubmed 出版商
Mahajan K, Coppola D, Rawal B, Chen Y, Lawrence H, Engelman R, et al. Ack1-mediated androgen receptor phosphorylation modulates radiation resistance in castration-resistant prostate cancer. J Biol Chem. 2012;287:22112-22 pubmed 出版商
Hsu C, Lee Y, Yeh S, Chen C, Wu C, Wang T, et al. 58-kDa microspherule protein (MSP58) is novel Brahma-related gene 1 (BRG1)-associated protein that modulates p53/p21 senescence pathway. J Biol Chem. 2012;287:22533-48 pubmed 出版商
Dellago H, Khan A, Nussbacher M, Gstraunthaler A, Lämmermann I, Schosserer M, et al. ATM-dependent phosphorylation of SNEVhPrp19/hPso4 is involved in extending cellular life span and suppression of apoptosis. Aging (Albany NY). 2012;4:290-304 pubmed
Ai L, Skehan R, Saydi J, Lin T, Brown K. Ataxia-Telangiectasia, Mutated (ATM)/Nuclear Factor ? light chain enhancer of activated B cells (NF?B) signaling controls basal and DNA damage-induced transglutaminase 2 expression. J Biol Chem. 2012;287:18330-41 pubmed 出版商
Zhang J, De Toledo S, Pandey B, Guo G, Pain D, Li H, et al. Role of the translationally controlled tumor protein in DNA damage sensing and repair. Proc Natl Acad Sci U S A. 2012;109:E926-33 pubmed 出版商
Kang M, So E, Ouchi T. Deregulation of DNA damage response pathway by intercellular contact. J Biol Chem. 2012;287:16246-55 pubmed 出版商
Hao Z, Duncan G, Su Y, Li W, Silvester J, Hong C, et al. The E3 ubiquitin ligase Mule acts through the ATM-p53 axis to maintain B lymphocyte homeostasis. J Exp Med. 2012;209:173-86 pubmed 出版商
Xu Y, Parmar K, Du F, Price B, Sun Y. The radioprotective agent WR1065 protects cells from radiation damage by regulating the activity of the Tip60 acetyltransferase. Int J Biochem Mol Biol. 2011;2:295-302 pubmed
Assaily W, Rubinger D, Wheaton K, Lin Y, Ma W, Xuan W, et al. ROS-mediated p53 induction of Lpin1 regulates fatty acid oxidation in response to nutritional stress. Mol Cell. 2011;44:491-501 pubmed 出版商
Sugimoto N, Yugawa T, Iizuka M, Kiyono T, Fujita M. Chromatin remodeler sucrose nonfermenting 2 homolog (SNF2H) is recruited onto DNA replication origins through interaction with Cdc10 protein-dependent transcript 1 (Cdt1) and promotes pre-replication complex formation. J Biol Chem. 2011;286:39200-10 pubmed 出版商
Brown J, Roberts T, Richards R, Woods R, Birrell G, Lim Y, et al. A novel role for hSMG-1 in stress granule formation. Mol Cell Biol. 2011;31:4417-29 pubmed 出版商
Hada M, Huff J, Patel Z, Kawata T, Pluth J, George K, et al. AT cells are not radiosensitive for simple chromosomal exchanges at low dose. Mutat Res. 2011;716:76-83 pubmed 出版商
Gatei M, Jakob B, Chen P, Kijas A, Becherel O, Gueven N, et al. ATM protein-dependent phosphorylation of Rad50 protein regulates DNA repair and cell cycle control. J Biol Chem. 2011;286:31542-56 pubmed 出版商
Luo K, Yuan J, Lou Z. Oligomerization of MDC1 protein is important for proper DNA damage response. J Biol Chem. 2011;286:28192-9 pubmed 出版商
Bouquet F, Ousset M, Biard D, Fallone F, Dauvillier S, Frit P, et al. A DNA-dependent stress response involving DNA-PK occurs in hypoxic cells and contributes to cellular adaptation to hypoxia. J Cell Sci. 2011;124:1943-51 pubmed 出版商
Shouse G, Nobumori Y, Panowicz M, Liu X. ATM-mediated phosphorylation activates the tumor-suppressive function of B56?-PP2A. Oncogene. 2011;30:3755-65 pubmed 出版商
Cherubini G, Naim V, Caruso P, Burla R, Bogliolo M, Cundari E, et al. The FANC pathway is activated by adenovirus infection and promotes viral replication-dependent recombination. Nucleic Acids Res. 2011;39:5459-73 pubmed 出版商
Chen Y, Chen C, Riley D, Chen P. Nek1 kinase functions in DNA damage response and checkpoint control through a pathway independent of ATM and ATR. Cell Cycle. 2011;10:655-63 pubmed
Matsumoto Y, Miyamoto T, Sakamoto H, Izumi H, Nakazawa Y, Ogi T, et al. Two unrelated patients with MRE11A mutations and Nijmegen breakage syndrome-like severe microcephaly. DNA Repair (Amst). 2011;10:314-21 pubmed 出版商
Urquhart A, Gatei M, Richard D, Khanna K. ATM mediated phosphorylation of CHD4 contributes to genome maintenance. Genome Integr. 2011;2:1 pubmed 出版商
Ruiz Z, Mihaylov I, Cotmore S, Tattersall P. Recruitment of DNA replication and damage response proteins to viral replication centers during infection with NS2 mutants of Minute Virus of Mice (MVM). Virology. 2011;410:375-84 pubmed 出版商
Kozlov S, Graham M, Jakob B, Tobias F, Kijas A, Tanuji M, et al. Autophosphorylation and ATM activation: additional sites add to the complexity. J Biol Chem. 2011;286:9107-19 pubmed 出版商
Powell M, Manandhar G, Spate L, Sutovsky M, Zimmerman S, Sachdev S, et al. Discovery of putative oocyte quality markers by comparative ExacTag proteomics. Proteomics Clin Appl. 2010;4:337-51 pubmed 出版商
Xu Y, Sun Y, Jiang X, Ayrapetov M, Moskwa P, Yang S, et al. The p400 ATPase regulates nucleosome stability and chromatin ubiquitination during DNA repair. J Cell Biol. 2010;191:31-43 pubmed 出版商
Huang Q, Tomida S, Masuda Y, Arima C, Cao K, Kasahara T, et al. Regulation of DNA polymerase POLD4 influences genomic instability in lung cancer. Cancer Res. 2010;70:8407-16 pubmed 出版商
Shanware N, Zhan L, Hutchinson J, Kim S, Williams L, Tibbetts R. Conserved and distinct modes of CREB/ATF transcription factor regulation by PP2A/B56gamma and genotoxic stress. PLoS ONE. 2010;5:e12173 pubmed 出版商
Lee J, Choy M, Ngo L, Foster S, Marks P. Histone deacetylase inhibitor induces DNA damage, which normal but not transformed cells can repair. Proc Natl Acad Sci U S A. 2010;107:14639-44 pubmed 出版商
Fang Z, Kozlov S, McKay M, Woods R, Birrell G, Sprung C, et al. Low levels of ATM in breast cancer patients with clinical radiosensitivity. Genome Integr. 2010;1:9 pubmed 出版商
Ousset M, Bouquet F, Fallone F, Biard D, Dray C, Valet P, et al. Loss of ATM positively regulates the expression of hypoxia inducible factor 1 (HIF-1) through oxidative stress: Role in the physiopathology of the disease. Cell Cycle. 2010;9:2814-22 pubmed
Bowen C, Gelmann E. NKX3.1 activates cellular response to DNA damage. Cancer Res. 2010;70:3089-97 pubmed 出版商
Kongruttanachok N, Phuangphairoj C, Thongnak A, Ponyeam W, Rattanatanyong P, Pornthanakasem W, et al. Replication independent DNA double-strand break retention may prevent genomic instability. Mol Cancer. 2010;9:70 pubmed 出版商
Wilhelm M, Rufini A, Wetzel M, Tsuchihara K, Inoue S, Tomasini R, et al. Isoform-specific p73 knockout mice reveal a novel role for delta Np73 in the DNA damage response pathway. Genes Dev. 2010;24:549-60 pubmed 出版商
Kodama M, Otsubo C, Hirota T, Yokota J, Enari M, Taya Y. Requirement of ATM for rapid p53 phosphorylation at Ser46 without Ser/Thr-Gln sequences. Mol Cell Biol. 2010;30:1620-33 pubmed 出版商
Hu H, Du L, Nagabayashi G, Seeger R, Gatti R. ATM is down-regulated by N-Myc-regulated microRNA-421. Proc Natl Acad Sci U S A. 2010;107:1506-11 pubmed 出版商
Yoshida K, Sugimoto N, Iwahori S, Yugawa T, Narisawa Saito M, Kiyono T, et al. CDC6 interaction with ATR regulates activation of a replication checkpoint in higher eukaryotic cells. J Cell Sci. 2010;123:225-35 pubmed 出版商
So S, Davis A, Chen D. Autophosphorylation at serine 1981 stabilizes ATM at DNA damage sites. J Cell Biol. 2009;187:977-90 pubmed 出版商
Bolderson E, Tomimatsu N, Richard D, Boucher D, Kumar R, Pandita T, et al. Phosphorylation of Exo1 modulates homologous recombination repair of DNA double-strand breaks. Nucleic Acids Res. 2010;38:1821-31 pubmed 出版商
Britton S, Frit P, Biard D, Salles B, Calsou P. ARTEMIS nuclease facilitates apoptotic chromatin cleavage. Cancer Res. 2009;69:8120-6 pubmed 出版商
Papp L, Lu J, Bolderson E, Boucher D, Singh R, Holmgren A, et al. SECIS-binding protein 2 promotes cell survival by protecting against oxidative stress. Antioxid Redox Signal. 2010;12:797-808 pubmed 出版商
Sun Y, Jiang X, Xu Y, Ayrapetov M, Moreau L, Whetstine J, et al. Histone H3 methylation links DNA damage detection to activation of the tumour suppressor Tip60. Nat Cell Biol. 2009;11:1376-82 pubmed 出版商
Sugimoto N, Yoshida K, Tatsumi Y, Yugawa T, Narisawa Saito M, Waga S, et al. Redundant and differential regulation of multiple licensing factors ensures prevention of re-replication in normal human cells. J Cell Sci. 2009;122:1184-91 pubmed 出版商
Cui B, Johnson S, Bullock N, Ali Osman F, Bigner D, Friedman H. Bifunctional DNA alkylator 1,3-bis(2-chloroethyl)-1-nitrosourea activates the ATR-Chk1 pathway independently of the mismatch repair pathway. Mol Pharmacol. 2009;75:1356-63 pubmed 出版商
Heffernan T, Kawasumi M, Blasina A, Anderes K, Conney A, Nghiem P. ATR-Chk1 pathway inhibition promotes apoptosis after UV treatment in primary human keratinocytes: potential basis for the UV protective effects of caffeine. J Invest Dermatol. 2009;129:1805-15 pubmed 出版商
Nahas S, Butch A, Du L, Gatti R. Rapid flow cytometry-based structural maintenance of chromosomes 1 (SMC1) phosphorylation assay for identification of ataxia-telangiectasia homozygotes and heterozygotes. Clin Chem. 2009;55:463-72 pubmed 出版商
Chou W, Wang H, Wong F, Ding S, Wu P, Shieh S, et al. Chk2-dependent phosphorylation of XRCC1 in the DNA damage response promotes base excision repair. EMBO J. 2008;27:3140-50 pubmed 出版商
Hein J, Boichuk S, Wu J, Cheng Y, Freire R, Jat P, et al. Simian virus 40 large T antigen disrupts genome integrity and activates a DNA damage response via Bub1 binding. J Virol. 2009;83:117-27 pubmed 出版商
Meulle A, Salles B, Daviaud D, Valet P, Muller C. Positive regulation of DNA double strand break repair activity during differentiation of long life span cells: the example of adipogenesis. PLoS ONE. 2008;3:e3345 pubmed 出版商
Martin L, Liu Z, Pipino J, Chestnut B, Landek M. Molecular regulation of DNA damage-induced apoptosis in neurons of cerebral cortex. Cereb Cortex. 2009;19:1273-93 pubmed 出版商
Stohr B, Blackburn E. ATM mediates cytotoxicity of a mutant telomerase RNA in human cancer cells. Cancer Res. 2008;68:5309-17 pubmed 出版商
Luo H, Li Y, Mu J, Zhang J, Tonaka T, Hamamori Y, et al. Regulation of intra-S phase checkpoint by ionizing radiation (IR)-dependent and IR-independent phosphorylation of SMC3. J Biol Chem. 2008;283:19176-83 pubmed 出版商
Wei G, Defeo K, Hayes C, Woster P, Mandik Nayak L, Gilmour S. Elevated ornithine decarboxylase levels activate ataxia telangiectasia mutated-DNA damage signaling in normal keratinocytes. Cancer Res. 2008;68:2214-22 pubmed 出版商
Sugimoto N, Kitabayashi I, Osano S, Tatsumi Y, Yugawa T, Narisawa Saito M, et al. Identification of novel human Cdt1-binding proteins by a proteomics approach: proteolytic regulation by APC/CCdh1. Mol Biol Cell. 2008;19:1007-21 pubmed
Lai C, Jeng K, Machida K, Cheng Y, Lai M. Hepatitis C virus NS3/4A protein interacts with ATM, impairs DNA repair and enhances sensitivity to ionizing radiation. Virology. 2008;370:295-309 pubmed
Wood J, Singh N, Mer G, Chen J. MCPH1 functions in an H2AX-dependent but MDC1-independent pathway in response to DNA damage. J Biol Chem. 2007;282:35416-23 pubmed
Sun Y, Xu Y, Roy K, Price B. DNA damage-induced acetylation of lysine 3016 of ATM activates ATM kinase activity. Mol Cell Biol. 2007;27:8502-9 pubmed
Iwahori S, Shirata N, Kawaguchi Y, Weller S, Sato Y, Kudoh A, et al. Enhanced phosphorylation of transcription factor sp1 in response to herpes simplex virus type 1 infection is dependent on the ataxia telangiectasia-mutated protein. J Virol. 2007;81:9653-64 pubmed
Fernandes N, Sun Y, Price B. Activation of the kinase activity of ATM by retinoic acid is required for CREB-dependent differentiation of neuroblastoma cells. J Biol Chem. 2007;282:16577-84 pubmed
Inoue Y, Kitagawa M, Taya Y. Phosphorylation of pRB at Ser612 by Chk1/2 leads to a complex between pRB and E2F-1 after DNA damage. EMBO J. 2007;26:2083-93 pubmed
Stauffer D, Chang B, Huang J, Dunn A, Thayer M. p300/CREB-binding protein interacts with ATR and is required for the DNA replication checkpoint. J Biol Chem. 2007;282:9678-87 pubmed
Shi Y, Dodson G, Mukhopadhyay P, Shanware N, Trinh A, Tibbetts R. Identification of carboxyl-terminal MCM3 phosphorylation sites using polyreactive phosphospecific antibodies. J Biol Chem. 2007;282:9236-43 pubmed
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Wu X, Shell S, Liu Y, Zou Y. ATR-dependent checkpoint modulates XPA nuclear import in response to UV irradiation. Oncogene. 2007;26:757-64 pubmed
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Tatsumi Y, Sugimoto N, Yugawa T, Narisawa Saito M, Kiyono T, Fujita M. Deregulation of Cdt1 induces chromosomal damage without rereplication and leads to chromosomal instability. J Cell Sci. 2006;119:3128-40 pubmed
Jiang X, Sun Y, Chen S, Roy K, Price B. The FATC domains of PIKK proteins are functionally equivalent and participate in the Tip60-dependent activation of DNA-PKcs and ATM. J Biol Chem. 2006;281:15741-6 pubmed
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Shiotani B, Kobayashi M, Watanabe M, Yamamoto K, Sugimura T, Wakabayashi K. Involvement of the ATR- and ATM-dependent checkpoint responses in cell cycle arrest evoked by pierisin-1. Mol Cancer Res. 2006;4:125-33 pubmed
Aglipay J, Martin S, Tawara H, Lee S, Ouchi T. ATM activation by ionizing radiation requires BRCA1-associated BAAT1. J Biol Chem. 2006;281:9710-8 pubmed
Wang H, Chou W, Shieh S, Shen C. Ataxia telangiectasia mutated and checkpoint kinase 2 regulate BRCA1 to promote the fidelity of DNA end-joining. Cancer Res. 2006;66:1391-400 pubmed
Gibson S, Bindra R, Glazer P. Hypoxia-induced phosphorylation of Chk2 in an ataxia telangiectasia mutated-dependent manner. Cancer Res. 2005;65:10734-41 pubmed
Dodson G, Tibbetts R. DNA replication stress-induced phosphorylation of cyclic AMP response element-binding protein mediated by ATM. J Biol Chem. 2006;281:1692-7 pubmed
Shi Y, Dodson G, Shaikh S, Rundell K, Tibbetts R. Ataxia-telangiectasia-mutated (ATM) is a T-antigen kinase that controls SV40 viral replication in vivo. J Biol Chem. 2005;280:40195-200 pubmed
Gueven N, Fukao T, Luff J, Paterson C, Kay G, Kondo N, et al. Regulation of the Atm promoter in vivo. Genes Chromosomes Cancer. 2006;45:61-71 pubmed
Sun Y, Jiang X, Chen S, Fernandes N, Price B. A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM. Proc Natl Acad Sci U S A. 2005;102:13182-7 pubmed
Kim J, Krasieva T, Kurumizaka H, Chen D, Taylor A, Yokomori K. Independent and sequential recruitment of NHEJ and HR factors to DNA damage sites in mammalian cells. J Cell Biol. 2005;170:341-7 pubmed
Young D, Jonnalagadda J, Gatei M, Jans D, Meyn S, Khanna K. Identification of domains of ataxia-telangiectasia mutated required for nuclear localization and chromatin association. J Biol Chem. 2005;280:27587-94 pubmed
Wang J, Pluth J, Cooper P, Cowan M, Chen D, Yannone S. Artemis deficiency confers a DNA double-strand break repair defect and Artemis phosphorylation status is altered by DNA damage and cell cycle progression. DNA Repair (Amst). 2005;4:556-70 pubmed
Peng Y, Woods R, Beamish H, Ye R, Lees Miller S, Lavin M, et al. Deficiency in the catalytic subunit of DNA-dependent protein kinase causes down-regulation of ATM. Cancer Res. 2005;65:1670-7 pubmed
Li J, Stern D. Regulation of CHK2 by DNA-dependent protein kinase. J Biol Chem. 2005;280:12041-50 pubmed
Kudoh A, Fujita M, Zhang L, Shirata N, Daikoku T, Sugaya Y, et al. Epstein-Barr virus lytic replication elicits ATM checkpoint signal transduction while providing an S-phase-like cellular environment. J Biol Chem. 2005;280:8156-63 pubmed
Lai C, Chun H, Nahas S, Mitui M, Gamo K, Du L, et al. Correction of ATM gene function by aminoglycoside-induced read-through of premature termination codons. Proc Natl Acad Sci U S A. 2004;101:15676-81 pubmed
Butch A, Chun H, Nahas S, Gatti R. Immunoassay to measure ataxia-telangiectasia mutated protein in cellular lysates. Clin Chem. 2004;50:2302-8 pubmed
Zhang X, Succi J, Feng Z, Prithivirajsingh S, Story M, Legerski R. Artemis is a phosphorylation target of ATM and ATR and is involved in the G2/M DNA damage checkpoint response. Mol Cell Biol. 2004;24:9207-20 pubmed
Silverman J, Takai H, Buonomo S, Eisenhaber F, de Lange T. Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint. Genes Dev. 2004;18:2108-19 pubmed
Xu X, Lee J, Stern D. Microcephalin is a DNA damage response protein involved in regulation of CHK1 and BRCA1. J Biol Chem. 2004;279:34091-4 pubmed
Dodson G, Shi Y, Tibbetts R. DNA replication defects, spontaneous DNA damage, and ATM-dependent checkpoint activation in replication protein A-deficient cells. J Biol Chem. 2004;279:34010-4 pubmed
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Panta G, Kaur S, Cavin L, Cortes M, Mercurio F, Lothstein L, et al. ATM and the catalytic subunit of DNA-dependent protein kinase activate NF-kappaB through a common MEK/extracellular signal-regulated kinase/p90(rsk) signaling pathway in response to distinct forms of DNA damage. Mol Cell Biol. 2004;24:1823-35 pubmed
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产品信息
目录号 :
GTX70103
产品名称 :
毛细血管扩张性共济失调症突变蛋白抗体[2C1]
宿主物种 :
小鼠
克隆性 :
单克隆
产品类型 :
一抗
规格 :
100.00μg
标价 :
299美元
Pubmed号列表 :
11799059,18846213,17074762,21889946,14681694,21137054,11479203,23337116,16513843,16835273,14651848,17426037,11003672,19147735,20080624,21460856,17380128,12796033,21227757,12034743,15811628,17242184,15054841,16432227,20356374,15753361,18162579,22566699,19783983,18424439,20123963,20026654,20876283,14871926,18593932,15929992,11606401,19339550,15486025,19959400,22213803,22431734,19261750,15498871,16061690,16603769,23028957,19808974,17925396,21193212,16141325,18922873,22563078,16452482,11278490,16540636,22451927,17158963,18337245,14570874,16221684,12645530,20048340,23211021,18971944,15220350,21150274,11805335,20676049,22187663,17189385,11466622,21301226,11319607,22055193,17923702,20678261,18667510,21911475,20730097,16322218,23303793,16949371,18381427,10783165,18820287,15668230,20395202,10716718,23157317,17272271,22529335,21149446,20861182,15159397,16858402,21421559,15197179,17609267,17671184,15456891,20019063,17090522,23178371,20304914,16452194,15611093,23437304,16862173,22493284,21219611,12228239,21705321,19803747,12883528,14990579,22693253,21937426,17244605,14966265,12082606,20194434,15342490,17062639,19242509,22972376,12967654,21576354,12939743,20679231,16180236,16952553,17224243,17931678,23525106,23667485,12214278,16293623,17209043,18442975,21757780,23197857,23474819,23878245,23890999,24342190,24662822,24933654,25105411,25113059,24763056,25240135,25533949,25535335,25770783,25757624,25826455
克隆 :
2C1
抗体亚型 :
IgG1
产品描述 :
Mouse monoclonal antibody [2C1] to ATM
交叉活性 :
Hu, Ms, Mk, Rat
背景 :
The ATM antibody, clone 2C1, recognizes full-length ATM, a 370kDa nuclear phosphoprotein, which is involved in the autosomal recessive disease ataxia telangiectasia (AT). ATM belongs to a novel family of proteins associated with cell cycle regulation and response to DNA repair. The C-terminal region has extensive homology to the catalytic domains of phosphatidylinositol 3-kinases (PI3 kinases). Its usefulness to monitor altered ATM expression in cancer is under active investigation.
免疫原 :
Recombinant protein expressed in E. coli corresponding to amino acids 2577-3056.
缓冲液 :
磷酸盐缓冲液, pH值7.4, 含无防腐剂
用途 :
酶联免疫吸附测定, 流式细胞仪, 免疫细胞化学/IF, 免疫组化-P, 免疫沉淀, 免疫印迹, 染色质免疫沉淀法
浓度 :
1毫克/毫升
一般参考 :
Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid freeze-thaw cycles.
图像Legend_4 :
Detection of human ATM protein using anti-ATM 2C1 monoclonal antibody (GTX70103) by western blot or immunoprecipitation.
图像Legend_5 :
Detection of ATM (Anti-ATM 2C1, GTX70103) or ATR (Anti-ATR 2B5,GTX70109) by western blot in human Raji whole cell extract.
图像Legend_6 :
ATM antibody [2C1] detects ATM protein by western blot analysis. A. 30 μg U87-MG whole cell lysate/extract . B. 30 μg SK-N-SH whole cell lysate/extract . C. 30 μg IMR32 whole cell lysate/extract . D. 30 μg SK-N-AS whole cell lysate/extract. 5 % SDS-PAGE. ATM antibody [2C1] (GTX70103) dilution: 1:1000
更多信息或购买 :
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公司信息
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