产品简要
公司名称 :
GeneTex
产品类型 :
抗体
产品名称 :
雌激素受体β抗体[7B10.7]
目录 :
GTX70182
规格 :
100.00μg
价格 :
299美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
nonconjugated
克隆名称 :
7B10.7
反应物种 :
人类
应用 :
免疫印迹, 免疫沉淀, 染色质免疫沉淀
更多信息或购买 :
GeneTex 产品网页
文章摘录数: 16
出版应用/物种/样品/稀释参考文献
  • 免疫印迹; 人类; 1:200; 图 1c
Nelson A, Groen A, Miller J, Warren A, Holmes K, Tarulli G, et al. Comprehensive assessment of estrogen receptor beta antibodies in cancer cell line models and tissue reveals critical limitations in reagent specificity. Mol Cell Endocrinol. 2017;440:138-150 pubmed 出版商
  • 染色质免疫沉淀 ; 人类; 图 1
Charn T, Liu E, Chang E, Lee Y, Katzenellenbogen J, Katzenellenbogen B. Genome-wide dynamics of chromatin binding of estrogen receptors alpha and beta: mutual restriction and competitive site selection. Mol Endocrinol. 2010;24:47-59 pubmed 出版商
  • 染色质免疫沉淀 ; 人类
Vivar O, Saunier E, Leitman D, Firestone G, Bjeldanes L. Selective activation of estrogen receptor-beta target genes by 3,3'-diindolylmethane. Endocrinology. 2010;151:1662-7 pubmed 出版商
Burakov D, Crofts L, Chang C, Freedman L. Reciprocal recruitment of DRIP/mediator and p160 coactivator complexes in vivo by estrogen receptor. J Biol Chem. 2002;277:14359-62 pubmed
Cvoro A, Paruthiyil S, Jones J, Tzagarakis-Foster C, Clegg N, Tatomer D, et al. Selective activation of estrogen receptor-beta transcriptional pathways by an herbal extract. Endocrinology. 2007;148:538-47 pubmed
Vivar O, Zhao X, Saunier E, Griffin C, Mayba O, Tagliaferri M, et al. Estrogen receptor beta binds to and regulates three distinct classes of target genes. J Biol Chem. 2010;285:22059-66 pubmed 出版商
Krishnamurthy N, Hu Y, Siedlak S, Doughman Y, Watanabe M, Montano M. Induction of quinone reductase by tamoxifen or DPN protects against mammary tumorigenesis. FASEB J. 2012;26:3993-4002 pubmed 出版商
Monsivais D, Dyson M, Yin P, Coon J, Navarro A, Feng G, et al. ERβ- and prostaglandin E2-regulated pathways integrate cell proliferation via Ras-like and estrogen-regulated growth inhibitor in endometriosis. Mol Endocrinol. 2014;28:1304-15 pubmed 出版商
Ruddy S, Lau R, Cabrita M, McGregor C, McKay B, Murphy L, et al. Preferential estrogen receptor β ligands reduce Bcl-2 expression in hormone-resistant breast cancer cells to increase autophagy. Mol Cancer Ther. 2014;13:1882-93 pubmed 出版商
Jiang Y, Gong P, Madak-Erdogan Z, Martin T, Jeyakumar M, Carlson K, et al. Mechanisms enforcing the estrogen receptor β selectivity of botanical estrogens. FASEB J. 2013;27:4406-18 pubmed 出版商
Madak-Erdogan Z, Charn T, Jiang Y, Liu E, Katzenellenbogen J, Katzenellenbogen B. Integrative genomics of gene and metabolic regulation by estrogen receptors α and β, and their coregulators. Mol Syst Biol. 2013;9:676 pubmed 出版商
Paruthiyil S, Cvoro A, Tagliaferri M, Cohen I, Shtivelman E, Leitman D. Estrogen receptor β causes a G2 cell cycle arrest by inhibiting CDK1 activity through the regulation of cyclin B1, GADD45A, and BTG2. Breast Cancer Res Treat. 2011;129:777-84 pubmed 出版商
Bianco N, Perry G, Smith M, Templeton D, Montano M. Functional implications of antiestrogen induction of quinone reductase: inhibition of estrogen-induced deoxyribonucleic acid damage. Mol Endocrinol. 2003;17:1344-55 pubmed
Cvoro A, Tzagarakis-Foster C, Tatomer D, Paruthiyil S, Fox M, Leitman D. Distinct roles of unliganded and liganded estrogen receptors in transcriptional repression. Mol Cell. 2006;21:555-64 pubmed
Tee M, Rogatsky I, Tzagarakis-Foster C, Cvoro A, An J, Christy R, et al. Estradiol and selective estrogen receptor modulators differentially regulate target genes with estrogen receptors alpha and beta. Mol Biol Cell. 2004;15:1262-72 pubmed
Chang E, Charn T, Park S, Helferich W, Komm B, Katzenellenbogen J, et al. Estrogen Receptors alpha and beta as determinants of gene expression: influence of ligand, dose, and chromatin binding. Mol Endocrinol. 2008;22:1032-43 pubmed 出版商
产品信息
目录号 :
GTX70182
产品名称 :
雌激素受体β抗体[7B10.7]
宿主物种 :
小鼠
克隆性 :
单克隆
产品类型 :
一抗
规格 :
100.00μg
标价 :
299美元
Pubmed号列表 :
20160136,14699072,21120602,16483936,20404318,19897598,22700872,17095596,12714703,11893728,18258689,23774759,23882126,24785256,24992181
克隆 :
7B10.7
抗体亚型 :
IgG1
产品描述 :
小鼠单克隆抗体人类雌激素受体β
交叉活性 :
Hu
背景 :
The human ER-beta is a newly discovered estrogen receptor initially cloned and characterized from testis. The size and structure of ER-beta is very similar to ER-alpha with the ligand and DNA binding domains being highly conserved, while the amino terminus which serves as their transactivation domain has diverged significantly. Similar in function to ER-alpha ER-beta binds to estrogen with a high affinity and regulates estrogen specific gene activation through direct interaction with estrogen response elements (ERE's).
免疫原 :
氨基酸1-153人的ER-§在大肠杆菌中表达
缓冲液 :
磷酸盐缓冲液, pH值7.4, 含无防腐剂
用途 :
免疫沉淀, 免疫印迹, 染色质免疫沉淀法
浓度 :
1毫克/毫升
一般参考 :
Keep as concentrated solution. Store at 4°C short term. For extended storage aliquot and store at -20°C or below. Avoid freeze-thaw cycles.
更多信息或购买 :
GeneTex 产品网页
公司信息
GeneTex
2456 Alton Pkwy
Irvine, CA92606
support@genetex.com
www.genetex.com
886-3-6208988
公司总部: 美国