产品简要
公司名称 :
GeneTex
产品类型 :
抗体
产品名称 :
Mre11抗体[12D7]
目录 :
GTX70212
规格 :
100.00μg
价格 :
299美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
12D7
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫细胞化学, 免疫沉淀, 免疫组化-石蜡切片
更多信息或购买 :
GeneTex 产品网页
文章摘录数: 119
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 人类; 图 4c
Meyerson N, Zhou L, Guo Y, Zhao C, Tao Y, Krug R, et al. Nuclear TRIM25 Specifically Targets Influenza Virus Ribonucleoproteins to Block the Onset of RNA Chain Elongation. Cell Host Microbe. 2017;22:627-638.e7 pubmed 出版商
  • 免疫印迹; 人类; 图 s2b
Smith E, Gole B, Willis N, Soria R, Starnes L, Krumpelbeck E, et al. DEK is required for homologous recombination repair of DNA breaks. Sci Rep. 2017;7:44662 pubmed 出版商
  • 免疫细胞化学; 人类; 图 2
Renaud E, Barascu A, Rosselli F. Impaired TIP60-mediated H4K16 acetylation accounts for the aberrant chromatin accumulation of 53BP1 and RAP80 in Fanconi anemia pathway-deficient cells. Nucleic Acids Res. 2016;44:648-56 pubmed 出版商
  • 免疫细胞化学; 人类; 图 6
Hollingworth R, Skalka G, Stewart G, Hislop A, Blackbourn D, Grand R. Activation of DNA Damage Response Pathways during Lytic Replication of KSHV. Viruses. 2015;7:2908-27 pubmed 出版商
  • 免疫印迹; 人类; 图 5
Harten S, Oey H, Bourke L, Bharti V, Isbel L, Daxinger L, et al. The recently identified modifier of murine metastable epialleles, Rearranged L-Myc Fusion, is involved in maintaining epigenetic marks at CpG island shores and enhancers. BMC Biol. 2015;13:21 pubmed 出版商
  • 免疫印迹; 人类; 图 4
Nakajima N, Hagiwara Y, Oike T, Okayasu R, Murakami T, Nakano T, et al. Pre-exposure to ionizing radiation stimulates DNA double strand break end resection, promoting the use of homologous recombination repair. PLoS ONE. 2015;10:e0122582 pubmed 出版商
  • 免疫细胞化学; 人类; 1:200; 图 s6c
Pathania S, Bade S, Le Guillou M, Burke K, Reed R, Bowman Colin C, et al. BRCA1 haploinsufficiency for replication stress suppression in primary cells. Nat Commun. 2014;5:5496 pubmed 出版商
  • 免疫印迹; 人类; 图 3
Hühn D, Kousholt A, Sørensen C, Sartori A. miR-19, a component of the oncogenic miR-17∼92 cluster, targets the DNA-end resection factor CtIP. Oncogene. 2015;34:3977-84 pubmed 出版商
  • 免疫印迹; 人类; 1:2000
O Sullivan R, Arnoult N, Lackner D, Oganesian L, Haggblom C, Corpet A, et al. Rapid induction of alternative lengthening of telomeres by depletion of the histone chaperone ASF1. Nat Struct Mol Biol. 2014;21:167-74 pubmed 出版商
  • 免疫细胞化学; 小鼠; 1:100; 图 s3
Schröder Heurich B, Wieland B, Lavin M, Schindler D, Dork T. Protective role of RAD50 on chromatin bridges during abnormal cytokinesis. FASEB J. 2014;28:1331-41 pubmed 出版商
  • 免疫细胞化学; 人类; 图 2d
  • 免疫印迹; 人类; 图 6a
Shibata A, Moiani D, Arvai A, Perry J, Harding S, Genois M, et al. DNA double-strand break repair pathway choice is directed by distinct MRE11 nuclease activities. Mol Cell. 2014;53:7-18 pubmed 出版商
  • 免疫细胞化学; 人类; 1:1000; 图 5
Karen K, Hearing P. Adenovirus core protein VII protects the viral genome from a DNA damage response at early times after infection. J Virol. 2011;85:4135-42 pubmed 出版商
  • 免疫印迹; 人类
Anderson V, Walton M, Eve P, Boxall K, Antoni L, Caldwell J, et al. CCT241533 is a potent and selective inhibitor of CHK2 that potentiates the cytotoxicity of PARP inhibitors. Cancer Res. 2011;71:463-72 pubmed 出版商
  • 免疫印迹; 人类
Guo Z, Deshpande R, Paull T. ATM activation in the presence of oxidative stress. Cell Cycle. 2010;9:4805-11 pubmed
Ly P, Brunner S, Shoshani O, Kim D, Lan W, Pyntikova T, et al. Chromosome segregation errors generate a diverse spectrum of simple and complex genomic rearrangements. Nat Genet. 2019;51:705-715 pubmed 出版商
Ahmed K, Pandita R, Singh D, Hunt C, Pandita T. β1-Integrin Impacts Rad51 Stability and DNA Double-Strand Break Repair by Homologous Recombination. Mol Cell Biol. 2018;38: pubmed 出版商
Hollingworth R, Horniblow R, Forrest C, Stewart G, Grand R. Localization of Double-Strand Break Repair Proteins to Viral Replication Compartments following Lytic Reactivation of Kaposi's Sarcoma-Associated Herpesvirus. J Virol. 2017;91: pubmed 出版商
Morales J, Richard P, Patidar P, Motea E, Dang T, Manley J, et al. XRN2 Links Transcription Termination to DNA Damage and Replication Stress. PLoS Genet. 2016;12:e1006107 pubmed 出版商
Huang Y, Chou W, Hsiung C, Hu L, Chu H, Shen C. FGFR2 regulates Mre11 expression and double-strand break repair via the MEK-ERK-POU1F1 pathway in breast tumorigenesis. Hum Mol Genet. 2015;24:3506-17 pubmed 出版商
Jian W, Xu H, Chen J, Xu Z, Levitt J, Stanley J, et al. Activity of CEP-9722, a poly (ADP-ribose) polymerase inhibitor, in urothelial carcinoma correlates inversely with homologous recombination repair response to DNA damage. Anticancer Drugs. 2014;25:878-86 pubmed 出版商
Zhou Y, Caron P, Legube G, Paull T. Quantitation of DNA double-strand break resection intermediates in human cells. Nucleic Acids Res. 2014;42:e19 pubmed 出版商
Kong X, Ball A, Pham H, Zeng W, Chen H, Schmiesing J, et al. Distinct functions of human cohesin-SA1 and cohesin-SA2 in double-strand break repair. Mol Cell Biol. 2014;34:685-98 pubmed 出版商
Lee J, Mand M, Deshpande R, Kinoshita E, Yang S, Wyman C, et al. Ataxia telangiectasia-mutated (ATM) kinase activity is regulated by ATP-driven conformational changes in the Mre11/Rad50/Nbs1 (MRN) complex. J Biol Chem. 2013;288:12840-51 pubmed 出版商
Inagaki H, Ohye T, Kogo H, Tsutsumi M, Kato T, Tong M, et al. Two sequential cleavage reactions on cruciform DNA structures cause palindrome-mediated chromosomal translocations. Nat Commun. 2013;4:1592 pubmed 出版商
Stewart R, Kozlov S, Matigian N, Wali G, Gatei M, Sutharsan R, et al. A patient-derived olfactory stem cell disease model for ataxia-telangiectasia. Hum Mol Genet. 2013;22:2495-509 pubmed 出版商
Simões M, Martins C, Ferreira F. Host DNA damage response facilitates African swine fever virus infection. Vet Microbiol. 2013;165:140-7 pubmed 出版商
Sohn S, Hearing P. Adenovirus regulates sumoylation of Mre11-Rad50-Nbs1 components through a paralog-specific mechanism. J Virol. 2012;86:9656-65 pubmed 出版商
Andrin C, McDonald D, Attwood K, Rodrigue A, Ghosh S, Mirzayans R, et al. A requirement for polymerized actin in DNA double-strand break repair. Nucleus. 2012;3:384-95 pubmed
Harding S, Bristow R. Discordance between phosphorylation and recruitment of 53BP1 in response to DNA double-strand breaks. Cell Cycle. 2012;11:1432-44 pubmed 出版商
Tomimatsu N, Mukherjee B, Deland K, Kurimasa A, Bolderson E, Khanna K, et al. Exo1 plays a major role in DNA end resection in humans and influences double-strand break repair and damage signaling decisions. DNA Repair (Amst). 2012;11:441-8 pubmed 出版商
Masuda Y, Noguchi K, Segawa H, Tanaka N, Katayama K, Mitsuhashi J, et al. Novel regulatory role for Kaposi's sarcoma-associated herpesvirus-encoded vFLIP in chemosensitization to bleomycin. Biochem Biophys Res Commun. 2011;415:305-12 pubmed 出版商
Yanagihara H, Kobayashi J, Tateishi S, Kato A, Matsuura S, Tauchi H, et al. NBS1 recruits RAD18 via a RAD6-like domain and regulates Pol ?-dependent translesion DNA synthesis. Mol Cell. 2011;43:788-97 pubmed 出版商
Della Maria J, Zhou Y, Tsai M, Kuhnlein J, Carney J, Paull T, et al. Human Mre11/human Rad50/Nbs1 and DNA ligase IIIalpha/XRCC1 protein complexes act together in an alternative nonhomologous end joining pathway. J Biol Chem. 2011;286:33845-53 pubmed 出版商
Gatei M, Jakob B, Chen P, Kijas A, Becherel O, Gueven N, et al. ATM protein-dependent phosphorylation of Rad50 protein regulates DNA repair and cell cycle control. J Biol Chem. 2011;286:31542-56 pubmed 出版商
Baydoun H, Pancewicz J, Nicot C. Human T-lymphotropic type 1 virus p30 inhibits homologous recombination and favors unfaithful DNA repair. Blood. 2011;117:5897-906 pubmed 出版商
Matsumoto Y, Miyamoto T, Sakamoto H, Izumi H, Nakazawa Y, Ogi T, et al. Two unrelated patients with MRE11A mutations and Nijmegen breakage syndrome-like severe microcephaly. DNA Repair (Amst). 2011;10:314-21 pubmed 出版商
Forrester N, Sedgwick G, Thomas A, Blackford A, Speiseder T, Dobner T, et al. Serotype-specific inactivation of the cellular DNA damage response during adenovirus infection. J Virol. 2011;85:2201-11 pubmed 出版商
Kozlov S, Graham M, Jakob B, Tobias F, Kijas A, Tanuji M, et al. Autophosphorylation and ATM activation: additional sites add to the complexity. J Biol Chem. 2011;286:9107-19 pubmed 出版商
Orazio N, Naeger C, Karlseder J, Weitzman M. The adenovirus E1b55K/E4orf6 complex induces degradation of the Bloom helicase during infection. J Virol. 2011;85:1887-92 pubmed 出版商
Luo Y, Chen A, Qiu J. Bocavirus infection induces a DNA damage response that facilitates viral DNA replication and mediates cell death. J Virol. 2011;85:133-45 pubmed 出版商
Adeyemi R, Landry S, Davis M, Weitzman M, Pintel D. Parvovirus minute virus of mice induces a DNA damage response that facilitates viral replication. PLoS Pathog. 2010;6:e1001141 pubmed 出版商
Balasubramanian N, Bai P, Buchek G, Korza G, Weller S. Physical interaction between the herpes simplex virus type 1 exonuclease, UL12, and the DNA double-strand break-sensing MRN complex. J Virol. 2010;84:12504-14 pubmed 出版商
Offer S, Pan Hammarstrom Q, Hammarstrom L, Harris R. Unique DNA repair gene variations and potential associations with the primary antibody deficiency syndromes IgAD and CVID. PLoS ONE. 2010;5:e12260 pubmed 出版商
Cha H, Lowe J, Li H, Lee J, Belova G, Bulavin D, et al. Wip1 directly dephosphorylates gamma-H2AX and attenuates the DNA damage response. Cancer Res. 2010;70:4112-22 pubmed 出版商
Chailleux C, Tyteca S, Papin C, Boudsocq F, Puget N, Courilleau C, et al. Physical interaction between the histone acetyl transferase Tip60 and the DNA double-strand breaks sensor MRN complex. Biochem J. 2010;426:365-71 pubmed 出版商
Dellaire G, Kepkay R, Bazett Jones D. High resolution imaging of changes in the structure and spatial organization of chromatin, gamma-H2A.X and the MRN complex within etoposide-induced DNA repair foci. Cell Cycle. 2009;8:3750-69 pubmed
Moody C, Laimins L. Human papillomaviruses activate the ATM DNA damage pathway for viral genome amplification upon differentiation. PLoS Pathog. 2009;5:e1000605 pubmed 出版商
Moschos S, Dodd N, Jukic D, Fayewicz S, Wang X, Becker D. Suppressing the high-level expression and function of ATM in advanced-stage melanomas does not sensitize the cells to ionizing radiation. Cancer Biol Ther. 2009;8:1815-25 pubmed
Lins S, Kim R, Krüger L, Chrzanowska K, Seemanova E, Digweed M. Clinical variability and expression of the NBN c.657del5 allele in Nijmegen Breakage Syndrome. Gene. 2009;447:12-7 pubmed 出版商
Collaco R, Bevington J, Bhrigu V, Kalman Maltese V, Trempe J. Adeno-associated virus and adenovirus coinfection induces a cellular DNA damage and repair response via redundant phosphatidylinositol 3-like kinase pathways. Virology. 2009;392:24-33 pubmed 出版商
Roques C, Coulombe Y, Delannoy M, Vignard J, Grossi S, Brodeur I, et al. MRE11-RAD50-NBS1 is a critical regulator of FANCD2 stability and function during DNA double-strand break repair. EMBO J. 2009;28:2400-13 pubmed 出版商
Vago R, Leva V, Biamonti G, Montecucco A. DNA ligase I and Nbs1 proteins associate in a complex and colocalize at replication factories. Cell Cycle. 2009;8:2600-7 pubmed
Turaga R, Paquet E, Sild M, Vignard J, Garand C, Johnson F, et al. The Werner syndrome protein affects the expression of genes involved in adipogenesis and inflammation in addition to cell cycle and DNA damage responses. Cell Cycle. 2009;8:2080-92 pubmed
Waltes R, Kalb R, Gatei M, Kijas A, Stumm M, Sobeck A, et al. Human RAD50 deficiency in a Nijmegen breakage syndrome-like disorder. Am J Hum Genet. 2009;84:605-16 pubmed 出版商
Schwartz R, Carson C, Schuberth C, Weitzman M. Adeno-associated virus replication induces a DNA damage response coordinated by DNA-dependent protein kinase. J Virol. 2009;83:6269-78 pubmed 出版商
Zheng L, Kanagaraj R, Mihaljevic B, Schwendener S, Sartori A, Gerrits B, et al. MRE11 complex links RECQ5 helicase to sites of DNA damage. Nucleic Acids Res. 2009;37:2645-57 pubmed 出版商
Karen K, Hoey P, Young C, Hearing P. Temporal regulation of the Mre11-Rad50-Nbs1 complex during adenovirus infection. J Virol. 2009;83:4565-73 pubmed 出版商
Carlessi L, De Filippis L, Lecis D, Vescovi A, Delia D. DNA-damage response, survival and differentiation in vitro of a human neural stem cell line in relation to ATM expression. Cell Death Differ. 2009;16:795-806 pubmed 出版商
Zou Y, Misri S, Shay J, Pandita T, Wright W. Altered states of telomere deprotection and the two-stage mechanism of replicative aging. Mol Cell Biol. 2009;29:2390-7 pubmed 出版商
Carson C, Orazio N, Lee D, Suh J, Bekker Jensen S, Araujo F, et al. Mislocalization of the MRN complex prevents ATR signaling during adenovirus infection. EMBO J. 2009;28:652-62 pubmed 出版商
Crosby M, Kulshreshtha R, Ivan M, Glazer P. MicroRNA regulation of DNA repair gene expression in hypoxic stress. Cancer Res. 2009;69:1221-9 pubmed 出版商
Déry U, Coulombe Y, Rodrigue A, Stasiak A, Richard S, Masson J. A glycine-arginine domain in control of the human MRE11 DNA repair protein. Mol Cell Biol. 2008;28:3058-69 pubmed 出版商
Cervelli T, Palacios J, Zentilin L, Mano M, Schwartz R, Weitzman M, et al. Processing of recombinant AAV genomes occurs in specific nuclear structures that overlap with foci of DNA-damage-response proteins. J Cell Sci. 2008;121:349-57 pubmed 出版商
Gregory D, Bachenheimer S. Characterization of mre11 loss following HSV-1 infection. Virology. 2008;373:124-36 pubmed 出版商
Haince J, McDonald D, Rodrigue A, Déry U, Masson J, Hendzel M, et al. PARP1-dependent kinetics of recruitment of MRE11 and NBS1 proteins to multiple DNA damage sites. J Biol Chem. 2008;283:1197-208 pubmed
Palii S, Van Emburgh B, Sankpal U, Brown K, Robertson K. DNA methylation inhibitor 5-Aza-2'-deoxycytidine induces reversible genome-wide DNA damage that is distinctly influenced by DNA methyltransferases 1 and 3B. Mol Cell Biol. 2008;28:752-71 pubmed
Schwartz R, Palacios J, Cassell G, Adam S, Giacca M, Weitzman M. The Mre11/Rad50/Nbs1 complex limits adeno-associated virus transduction and replication. J Virol. 2007;81:12936-45 pubmed
Murakawa Y, Sonoda E, Barber L, Zeng W, Yokomori K, Kimura H, et al. Inhibitors of the proteasome suppress homologous DNA recombination in mammalian cells. Cancer Res. 2007;67:8536-43 pubmed
Xu M, Myerson R, Xia Y, Whitehead T, Moros E, Straube W, et al. The effects of 41 degrees C hyperthermia on the DNA repair protein, MRE11, correlate with radiosensitization in four human tumor cell lines. Int J Hyperthermia. 2007;23:343-51 pubmed
Cho Y, Hong T, Hong S, Guo H, Yu H, Kim D, et al. PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex. J Biol Chem. 2007;282:20395-406 pubmed
Fleisig H, Orazio N, Liang H, Tyler A, Adams H, Weitzman M, et al. Adenoviral E1B55K oncoprotein sequesters candidate leukemia suppressor sequence-specific single-stranded DNA-binding protein 2 into aggresomes. Oncogene. 2007;26:4797-805 pubmed
Woo J, Berk A. Adenovirus ubiquitin-protein ligase stimulates viral late mRNA nuclear export. J Virol. 2007;81:575-87 pubmed
Barcaroli D, Dinsdale D, Neale M, Bongiorno Borbone L, Ranalli M, Munarriz E, et al. FLASH is an essential component of Cajal bodies. Proc Natl Acad Sci U S A. 2006;103:14802-7 pubmed
Barcaroli D, Bongiorno Borbone L, Terrinoni A, Hofmann T, Rossi M, Knight R, et al. FLASH is required for histone transcription and S-phase progression. Proc Natl Acad Sci U S A. 2006;103:14808-12 pubmed
Dote H, Burgan W, Camphausen K, Tofilon P. Inhibition of hsp90 compromises the DNA damage response to radiation. Cancer Res. 2006;66:9211-20 pubmed
Nakanishi K, Kumaki F, Hiroi S, Mukai M, Ikeda E, Kawai T. Mre11 expression in atypical adenomatous hyperplasia and adenocarcinoma of the lung. Arch Pathol Lab Med. 2006;130:1330-4 pubmed
Lovejoy C, Lock K, Yenamandra A, Cortez D. DDB1 maintains genome integrity through regulation of Cdt1. Mol Cell Biol. 2006;26:7977-90 pubmed
Takemura H, Rao V, Sordet O, Furuta T, Miao Z, Meng L, et al. Defective Mre11-dependent activation of Chk2 by ataxia telangiectasia mutated in colorectal carcinoma cells in response to replication-dependent DNA double strand breaks. J Biol Chem. 2006;281:30814-23 pubmed
Kozlov S, Graham M, Peng C, Chen P, Robinson P, Lavin M. Involvement of novel autophosphorylation sites in ATM activation. EMBO J. 2006;25:3504-14 pubmed
Krüger L, Demuth I, Neitzel H, Varon R, Sperling K, Chrzanowska K, et al. Cancer incidence in Nijmegen breakage syndrome is modulated by the amount of a variant NBS protein. Carcinogenesis. 2007;28:107-11 pubmed
Bekker Jensen S, Lukas C, Kitagawa R, Melander F, Kastan M, Bartek J, et al. Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks. J Cell Biol. 2006;173:195-206 pubmed
Gueven N, Becherel O, Birrell G, Chen P, DelSal G, Carney J, et al. Defective p53 response and apoptosis associated with an ataxia-telangiectasia-like phenotype. Cancer Res. 2006;66:2907-12 pubmed
Varon R, Dutrannoy V, Weikert G, Tanzarella C, Antoccia A, Stockl L, et al. Mild Nijmegen breakage syndrome phenotype due to alternative splicing. Hum Mol Genet. 2006;15:679-89 pubmed
Chai W, Sfeir A, Hoshiyama H, Shay J, Wright W. The involvement of the Mre11/Rad50/Nbs1 complex in the generation of G-overhangs at human telomeres. EMBO Rep. 2006;7:225-30 pubmed
Al Rashid S, Dellaire G, Cuddihy A, Jalali F, Vaid M, Coackley C, et al. Evidence for the direct binding of phosphorylated p53 to sites of DNA breaks in vivo. Cancer Res. 2005;65:10810-21 pubmed
Kim J, Krasieva T, Kurumizaka H, Chen D, Taylor A, Yokomori K. Independent and sequential recruitment of NHEJ and HR factors to DNA damage sites in mammalian cells. J Cell Biol. 2005;170:341-7 pubmed
van Veelen L, Cervelli T, van de Rakt M, Theil A, Essers J, Kanaar R. Analysis of ionizing radiation-induced foci of DNA damage repair proteins. Mutat Res. 2005;574:22-33 pubmed
Vo A, Zhu F, Wu X, Yuan F, Gao Y, Gu L, et al. hMRE11 deficiency leads to microsatellite instability and defective DNA mismatch repair. EMBO Rep. 2005;6:438-44 pubmed
Lilley C, Carson C, Muotri A, Gage F, Weitzman M. DNA repair proteins affect the lifecycle of herpes simplex virus 1. Proc Natl Acad Sci U S A. 2005;102:5844-9 pubmed
Fan R, Kumaravel T, Jalali F, Marrano P, Squire J, Bristow R. Defective DNA strand break repair after DNA damage in prostate cancer cells: implications for genetic instability and prostate cancer progression. Cancer Res. 2004;64:8526-33 pubmed
Hart L, Yannone S, Naczki C, Orlando J, Waters S, Akman S, et al. The adenovirus E4orf6 protein inhibits DNA double strand break repair and radiosensitizes human tumor cells in an E1B-55K-independent manner. J Biol Chem. 2005;280:1474-81 pubmed
Zhang X, Succi J, Feng Z, Prithivirajsingh S, Story M, Legerski R. Artemis is a phosphorylation target of ATM and ATR and is involved in the G2/M DNA damage checkpoint response. Mol Cell Biol. 2004;24:9207-20 pubmed
Pichierri P, Franchitto A, Rosselli F. BLM and the FANC proteins collaborate in a common pathway in response to stalled replication forks. EMBO J. 2004;23:3154-63 pubmed
Robison J, Elliott J, Dixon K, Oakley G. Replication protein A and the Mre11.Rad50.Nbs1 complex co-localize and interact at sites of stalled replication forks. J Biol Chem. 2004;279:34802-10 pubmed
Wilkinson D, Weller S. Recruitment of cellular recombination and repair proteins to sites of herpes simplex virus type 1 DNA replication is dependent on the composition of viral proteins within prereplicative sites and correlates with the induction of the DNA damage respon. J Virol. 2004;78:4783-96 pubmed
Dork T, Bendix Waltes R, Wegner R, Stumm M. Slow progression of ataxia-telangiectasia with double missense and in frame splice mutations. Am J Med Genet A. 2004;126A:272-7 pubmed
Giannini G, Rinaldi C, Ristori E, Ambrosini M, Cerignoli F, Viel A, et al. Mutations of an intronic repeat induce impaired MRE11 expression in primary human cancer with microsatellite instability. Oncogene. 2004;23:2640-7 pubmed
Horejsi Z, Falck J, Bakkenist C, Kastan M, Lukas J, Bartek J. Distinct functional domains of Nbs1 modulate the timing and magnitude of ATM activation after low doses of ionizing radiation. Oncogene. 2004;23:3122-7 pubmed
Carson C, Schwartz R, Stracker T, Lilley C, Lee D, Weitzman M. The Mre11 complex is required for ATM activation and the G2/M checkpoint. EMBO J. 2003;22:6610-20 pubmed
Uziel T, Lerenthal Y, Moyal L, Andegeko Y, Mittelman L, Shiloh Y. Requirement of the MRN complex for ATM activation by DNA damage. EMBO J. 2003;22:5612-21 pubmed
Xu X, Stern D. NFBD1/MDC1 regulates ionizing radiation-induced focus formation by DNA checkpoint signaling and repair factors. FASEB J. 2003;17:1842-8 pubmed
Gottwein E, Bodem J, Muller B, Schmechel A, Zentgraf H, Kräusslich H. The Mason-Pfizer monkey virus PPPY and PSAP motifs both contribute to virus release. J Virol. 2003;77:9474-85 pubmed
Lee J, Xu B, Lee C, Ahn J, Song M, Lee H, et al. Distinct functions of Nijmegen breakage syndrome in ataxia telangiectasia mutated-dependent responses to DNA damage. Mol Cancer Res. 2003;1:674-81 pubmed
Celeste A, Fernandez Capetillo O, Kruhlak M, Pilch D, Staudt D, Lee A, et al. Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks. Nat Cell Biol. 2003;5:675-9 pubmed
Stewart G, Wang B, Bignell C, Taylor A, Elledge S. MDC1 is a mediator of the mammalian DNA damage checkpoint. Nature. 2003;421:961-6 pubmed
Lukas C, Falck J, Bartkova J, Bartek J, Lukas J. Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage. Nat Cell Biol. 2003;5:255-60 pubmed
Her C, Vo A, Wu X. Evidence for a direct association of hMRE11 with the human mismatch repair protein hMLH1. DNA Repair (Amst). 2002;1:719-29 pubmed
Xu X, Stern D. NFBD1/KIAA0170 is a chromatin-associated protein involved in DNA damage signaling pathways. J Biol Chem. 2003;278:8795-803 pubmed
Nakanishi K, Taniguchi T, Ranganathan V, New H, Moreau L, Stotsky M, et al. Interaction of FANCD2 and NBS1 in the DNA damage response. Nat Cell Biol. 2002;4:913-20 pubmed
Richie C, Peterson C, Lu T, Hittelman W, Carpenter P, Legerski R. hSnm1 colocalizes and physically associates with 53BP1 before and after DNA damage. Mol Cell Biol. 2002;22:8635-47 pubmed
Pichierri P, Averbeck D, Rosselli F. DNA cross-link-dependent RAD50/MRE11/NBS1 subnuclear assembly requires the Fanconi anemia C protein. Hum Mol Genet. 2002;11:2531-46 pubmed
Kim J, Krasieva T, LaMorte V, Taylor A, Yokomori K. Specific recruitment of human cohesin to laser-induced DNA damage. J Biol Chem. 2002;277:45149-53 pubmed
Xu M, Myerson R, Straube W, Moros E, Lagroye I, Wang L, et al. Radiosensitization of heat resistant human tumour cells by 1 hour at 41.1 degrees C and its effect on DNA repair. Int J Hyperthermia. 2002;18:385-403 pubmed
Stracker T, Carson C, Weitzman M. Adenovirus oncoproteins inactivate the Mre11-Rad50-NBS1 DNA repair complex. Nature. 2002;418:348-52 pubmed
Limoli C, Giedzinski E, Bonner W, Cleaver J. UV-induced replication arrest in the xeroderma pigmentosum variant leads to DNA double-strand breaks, gamma -H2AX formation, and Mre11 relocalization. Proc Natl Acad Sci U S A. 2002;99:233-8 pubmed
Harfst E, Cooper S, Neubauer S, Distel L, Grawunder U. Normal V(D)J recombination in cells from patients with Nijmegen breakage syndrome. Mol Immunol. 2000;37:915-29 pubmed
Lombard D, Guarente L. Nijmegen breakage syndrome disease protein and MRE11 at PML nuclear bodies and meiotic telomeres. Cancer Res. 2000;60:2331-4 pubmed
Gatei M, Young D, Cerosaletti K, Desai Mehta A, Spring K, Kozlov S, et al. ATM-dependent phosphorylation of nibrin in response to radiation exposure. Nat Genet. 2000;25:115-9 pubmed
Wang Y, Cortez D, Yazdi P, Neff N, Elledge S, Qin J. BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures. Genes Dev. 2000;14:927-39 pubmed
产品信息
目录号 :
GTX70212
产品名称 :
Mre11抗体[12D7]
宿主物种 :
小鼠
克隆性 :
单克隆
产品类型 :
一抗
规格 :
100.00μg
标价 :
299美元
Pubmed号列表 :
24362840,24413054,24344331,24324008,12499369,11282395,19855159,15048089,19409520,17003126,18025084,10802669,21159879,17003125,16940174,17558733,20949077,12228239,19244322,21757780,19339345,15180989,19229246,22688650,16415040,15824307,15054841,21047968,15456891,14519663,19597347,15864295,16858402,10783165,20070254,21239475,22421153,17875693,22740413,21149446,21427292,18216333,17991895,20805886,11756691,19635536,19628243,15048091,19684476,16905549,14657032,21123383,12861053,19609304,16618811,12124628,12792649,12607005,21884979,12447395,22037577,17898048,21227757,15574758,20943970,15914204,15078960,15257300,16322227,16840438,19141645,16374507,16982765,18285453,22326273,19502800,16948520,10811102,21150274,19197236,20460517,19270065,17500065,15507430,16061690,19223460,17079297,18177684,21816818,12446782,12354779,14532133,12598907,21345950,16540636,17311003,23481400,12227926,12509276,12915562,23398667,23474819,23525106,19798429,24714082,25400221,25788520,25857663,25826455
克隆 :
12D7
抗体亚型 :
IgG1
产品描述 :
Mouse monoclonal [12D7] to MRE11
交叉活性 :
Hu, Ms
背景 :
Mre11 is an 80 kDa protein that acts as a Mn+2 dependent double stranded DNA 3' to 5' exonuclease and a single stranded DNA endonuclease. It is part of a larger complex with Rad50, p95 (Nibrin) and possibly other associated proteins involved in the nucleolytic end-processing of double strand breaks and telomere maintenance.
免疫原 :
Amino acids 182-582 of Mre11 expressed in E. coli.
缓冲液 :
磷酸盐缓冲液, pH值7.4, 含无防腐剂
用途 :
ELISA, ICC/IF, IHC-P, IP, WB, Functional Assay
浓度 :
1毫克/毫升
一般参考 :
Keep as concentrated solution. Store at 4°C short term. For extended storage aliquot and store at -20°C or below. Avoid freeze-thaw cycles.
图像Legend_4 :
Mre11 antibody [12D7] detects Mre11 protein by western blot analysis. A. 30 μg HeLa whole cell extract. 7.5 % SDS-PAGE. Mre11 antibody [12D7] (GTX70212) dilution: 1:1000
更多信息或购买 :
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