产品简要
公司名称 :
GeneTex
产品类型 :
抗体
产品名称 :
Rad50抗体[13B3]
目录 :
GTX70228
规格 :
100.00μg
价格 :
299美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
13B3
反应物种 :
人类, 小鼠, 大鼠, 大肠埃希杆菌
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 染色质免疫沉淀
更多信息或购买 :
文章摘录数: 95
出版应用/物种/样本/稀释 | 参考文献 |
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Mariggiò G, Koch S, Zhang G, Weidner Glunde M, Rückert J, Kati S, et al. Kaposi Sarcoma Herpesvirus (KSHV) Latency-Associated Nuclear Antigen (LANA) recruits components of the MRN (Mre11-Rad50-NBS1) repair complex to modulate an innate immune signaling pathway and viral latency. PLoS Pathog. 2017;13:e1006335 pubmed 出版商
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Liu L, Bailey S, Okuka M, Muñoz P, Li C, Zhou L, et al. Telomere lengthening early in development. Nat Cell Biol. 2007;9:1436-41 pubmed
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Schwartz R, Palacios J, Cassell G, Adam S, Giacca M, Weitzman M. The Mre11/Rad50/Nbs1 complex limits adeno-associated virus transduction and replication. J Virol. 2007;81:12936-45 pubmed
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Zhong Z, Jiang W, Cesare A, Neumann A, Wadhwa R, Reddel R. Disruption of telomere maintenance by depletion of the MRE11/RAD50/NBS1 complex in cells that use alternative lengthening of telomeres. J Biol Chem. 2007;282:29314-22 pubmed
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Bentle M, Reinicke K, Dong Y, Bey E, Boothman D. Nonhomologous end joining is essential for cellular resistance to the novel antitumor agent, beta-lapachone. Cancer Res. 2007;67:6936-45 pubmed
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Potts P, Yu H. The SMC5/6 complex maintains telomere length in ALT cancer cells through SUMOylation of telomere-binding proteins. Nat Struct Mol Biol. 2007;14:581-90 pubmed
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Cho Y, Hong T, Hong S, Guo H, Yu H, Kim D, et al. PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex. J Biol Chem. 2007;282:20395-406 pubmed
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Bae N, Baumann P. A RAP1/TRF2 complex inhibits nonhomologous end-joining at human telomeric DNA ends. Mol Cell. 2007;26:323-34 pubmed
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Lin X, Liu C, Gao Q, Zhang X, Wu G, Lee W. RINT-1 serves as a tumor suppressor and maintains Golgi dynamics and centrosome integrity for cell survival. Mol Cell Biol. 2007;27:4905-16 pubmed
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You K, Li L, Kim N, Kang H, Koh K, Chwae Y, et al. Selective translational repression of truncated proteins from frameshift mutation-derived mRNAs in tumors. PLoS Biol. 2007;5:e109 pubmed
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Fleisig H, Orazio N, Liang H, Tyler A, Adams H, Weitzman M, et al. Adenoviral E1B55K oncoprotein sequesters candidate leukemia suppressor sequence-specific single-stranded DNA-binding protein 2 into aggresomes. Oncogene. 2007;26:4797-805 pubmed
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Dote H, Burgan W, Camphausen K, Tofilon P. Inhibition of hsp90 compromises the DNA damage response to radiation. Cancer Res. 2006;66:9211-20 pubmed
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Takemura H, Rao V, Sordet O, Furuta T, Miao Z, Meng L, et al. Defective Mre11-dependent activation of Chk2 by ataxia telangiectasia mutated in colorectal carcinoma cells in response to replication-dependent DNA double strand breaks. J Biol Chem. 2006;281:30814-23 pubmed
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Kong L, Meloni A, Nevins J. The Rb-related p130 protein controls telomere lengthening through an interaction with a Rad50-interacting protein, RINT-1. Mol Cell. 2006;22:63-71 pubmed
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Myers J, Cortez D. Rapid activation of ATR by ionizing radiation requires ATM and Mre11. J Biol Chem. 2006;281:9346-50 pubmed
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Tommiska J, Seal S, Renwick A, Barfoot R, Baskcomb L, Jayatilake H, et al. Evaluation of RAD50 in familial breast cancer predisposition. Int J Cancer. 2006;118:2911-6 pubmed
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van der Burg M, van Veelen L, Verkaik N, Wiegant W, Hartwig N, Barendregt B, et al. A new type of radiosensitive T-B-NK+ severe combined immunodeficiency caused by a LIG4 mutation. J Clin Invest. 2006;116:137-45 pubmed
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Mongiat Artus P, Miquel C, van der Aa M, Buhard O, Hamelin R, Soliman H, et al. Microsatellite instability and mutation analysis of candidate genes in urothelial cell carcinomas of upper urinary tract. Oncogene. 2006;25:2113-8 pubmed
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Liu Y, Shevchenko A, Shevchenko A, Berk A. Adenovirus exploits the cellular aggresome response to accelerate inactivation of the MRN complex. J Virol. 2005;79:14004-16 pubmed
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Kim J, Krasieva T, Kurumizaka H, Chen D, Taylor A, Yokomori K. Independent and sequential recruitment of NHEJ and HR factors to DNA damage sites in mammalian cells. J Cell Biol. 2005;170:341-7 pubmed
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Koh K, Kang H, Li L, Kim N, You K, Yang E, et al. Impaired nonhomologous end-joining in mismatch repair-deficient colon carcinomas. Lab Invest. 2005;85:1130-8 pubmed
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van Veelen L, Cervelli T, van de Rakt M, Theil A, Essers J, Kanaar R. Analysis of ionizing radiation-induced foci of DNA damage repair proteins. Mutat Res. 2005;574:22-33 pubmed
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Lilley C, Carson C, Muotri A, Gage F, Weitzman M. DNA repair proteins affect the lifecycle of herpes simplex virus 1. Proc Natl Acad Sci U S A. 2005;102:5844-9 pubmed
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Fasching C, Bower K, Reddel R. Telomerase-independent telomere length maintenance in the absence of alternative lengthening of telomeres-associated promyelocytic leukemia bodies. Cancer Res. 2005;65:2722-9 pubmed
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Angele S, Jones C, Reis Filho J, Fulford L, Treilleux I, Lakhani S, et al. Expression of ATM, p53, and the MRE11-Rad50-NBS1 complex in myoepithelial cells from benign and malignant proliferations of the breast. J Clin Pathol. 2004;57:1179-84 pubmed
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O Connor M, Safari A, Liu D, Qin J, Songyang Z. The human Rap1 protein complex and modulation of telomere length. J Biol Chem. 2004;279:28585-91 pubmed
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Wilkinson D, Weller S. Recruitment of cellular recombination and repair proteins to sites of herpes simplex virus type 1 DNA replication is dependent on the composition of viral proteins within prereplicative sites and correlates with the induction of the DNA damage respon. J Virol. 2004;78:4783-96 pubmed
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Dork T, Bendix Waltes R, Wegner R, Stumm M. Slow progression of ataxia-telangiectasia with double missense and in frame splice mutations. Am J Med Genet A. 2004;126A:272-7 pubmed
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Giannini G, Rinaldi C, Ristori E, Ambrosini M, Cerignoli F, Viel A, et al. Mutations of an intronic repeat induce impaired MRE11 expression in primary human cancer with microsatellite instability. Oncogene. 2004;23:2640-7 pubmed
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Carson C, Schwartz R, Stracker T, Lilley C, Lee D, Weitzman M. The Mre11 complex is required for ATM activation and the G2/M checkpoint. EMBO J. 2003;22:6610-20 pubmed
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Uziel T, Lerenthal Y, Moyal L, Andegeko Y, Mittelman L, Shiloh Y. Requirement of the MRN complex for ATM activation by DNA damage. EMBO J. 2003;22:5612-21 pubmed
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Xu X, Stern D. NFBD1/MDC1 regulates ionizing radiation-induced focus formation by DNA checkpoint signaling and repair factors. FASEB J. 2003;17:1842-8 pubmed
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Angele S, Treilleux I, Bremond A, Taniere P, Hall J. Altered expression of DNA double-strand break detection and repair proteins in breast carcinomas. Histopathology. 2003;43:347-53 pubmed
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Stewart G, Wang B, Bignell C, Taylor A, Elledge S. MDC1 is a mediator of the mammalian DNA damage checkpoint. Nature. 2003;421:961-6 pubmed
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Anderson L, Perkins N. Regulation of RelA (p65) function by the large subunit of replication factor C. Mol Cell Biol. 2003;23:721-32 pubmed
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Hassane D, Lee R, Pickett C. Campylobacter jejuni cytolethal distending toxin promotes DNA repair responses in normal human cells. Infect Immun. 2003;71:541-5 pubmed
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Richie C, Peterson C, Lu T, Hittelman W, Carpenter P, Legerski R. hSnm1 colocalizes and physically associates with 53BP1 before and after DNA damage. Mol Cell Biol. 2002;22:8635-47 pubmed
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Pichierri P, Averbeck D, Rosselli F. DNA cross-link-dependent RAD50/MRE11/NBS1 subnuclear assembly requires the Fanconi anemia C protein. Hum Mol Genet. 2002;11:2531-46 pubmed
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Kim J, Krasieva T, LaMorte V, Taylor A, Yokomori K. Specific recruitment of human cohesin to laser-induced DNA damage. J Biol Chem. 2002;277:45149-53 pubmed
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Stracker T, Carson C, Weitzman M. Adenovirus oncoproteins inactivate the Mre11-Rad50-NBS1 DNA repair complex. Nature. 2002;418:348-52 pubmed
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Franchitto A, Pichierri P. Bloom's syndrome protein is required for correct relocalization of RAD50/MRE11/NBS1 complex after replication fork arrest. J Cell Biol. 2002;157:19-30 pubmed
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Harfst E, Cooper S, Neubauer S, Distel L, Grawunder U. Normal V(D)J recombination in cells from patients with Nijmegen breakage syndrome. Mol Immunol. 2000;37:915-29 pubmed
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Tauchi H, Kobayashi J, Morishima K, Matsuura S, Nakamura A, Shiraishi T, et al. The forkhead-associated domain of NBS1 is essential for nuclear foci formation after irradiation but not essential for hRAD50[middle dot]hMRE11[middle dot]NBS1 complex DNA repair activity. J Biol Chem. 2001;276:12-5 pubmed
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Paull T, Rogakou E, Yamazaki V, Kirchgessner C, Gellert M, Bonner W. A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage. Curr Biol. 2000;10:886-95 pubmed
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Wang Y, Cortez D, Yazdi P, Neff N, Elledge S, Qin J. BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures. Genes Dev. 2000;14:927-39 pubmed
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产品信息
目录号 :
GTX70228
产品名称 :
Rad50抗体[13B3]
宿主物种 :
小鼠
克隆性 :
单克隆
产品类型 :
一抗
规格 :
100.00μg
标价 :
299美元
Pubmed号列表 :
24324008,14511253,19270065,20974981,12228239,12607005,15054841,15914204,12509469,20923785,21240277,16905549,15805271,17470549,15078960,16288216,11062235,15100233,10783165,21427292,21227757,18562516,17898048,16260778,14519663,12354779,21880593,19339345,17500065,22037577,19197236,18216333,12496208,19628243,19409520,20943970,19383352,20509860,21047968,16385572,17456004,18177684,20010693,22983061,17638905,16600870,16061690,11282395,12446782,14532133,20070254,10959836,15509680,21045143,17499040,21239475,17693401,16982765,16025146,11916980,16254336,15824307,20460517,14657032,12124628,15048091,16431910,16357942,17311003,17589526,17982445,23728299,23285190,23285130,23398667,23525106,23341130,18614635,19798429,20976220,24577941,24614819,25788520,25857663,25828805
克隆 :
13B3
抗体亚型 :
IgG1
产品描述 :
Mouse monoclonal [13B3] to Rad50
交叉活性 :
Hu, Ms, Mk, Rat
背景 :
RAD50 is an essential gene for all cell types and the expression does not vary during cell cycle. It is an excellent loading control at the high molecular weight position (150KD), complementing GAPDH, beta-Actin and alpha-Tubulin at the lower molecular weight positions.
免疫原 :
Amino acids 1-425 of Rad50 expressed in E. coli.
缓冲液 :
磷酸盐缓冲液, pH值7.4, 含无防腐剂
用途 :
免疫细胞化学/IF, 免疫组化, 免疫沉淀, 免疫印迹
浓度 :
1毫克/毫升
一般参考 :
Keep as concentrated solution. Store at 4°C short term. For extended storage aliquot and store at -20°C or below. Avoid freeze-thaw cycles.
更多信息或购买 :
公司信息
GeneTex
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