产品简要
公司名称 :
GeneTex
产品类型 :
抗体
产品名称 :
LC3B抗体
目录 :
GTX82986
规格 :
100.00μl
价格 :
299美元
克隆性 :
多克隆
宿主 :
兔
共轭标签 :
nonconjugated
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 流式细胞仪, 免疫组化-冰冻切片
更多信息或购买 :
GeneTex 产品网页
文章摘录数: 8
出版应用/物种/样品/稀释参考文献
  • 免疫印迹; 小鼠; 1:2000; 图 2
Sukseree S, Chen Y, Laggner M, Gruber F, Petit V, Nagelreiter I, et al. Tyrosinase-Cre-Mediated Deletion of the Autophagy Gene Atg7 Leads to Accumulation of the RPE65 Variant M450 in the Retinal Pigment Epithelium of C57BL/6 Mice. PLoS ONE. 2016;11:e0161640 pubmed 出版商
  • 免疫印迹; 人类; 图 4
Colangelo T, Polcaro G, Ziccardi P, Muccillo L, Galgani M, Pucci B, et al. The miR-27a-calreticulin axis affects drug-induced immunogenic cell death in human colorectal cancer cells. Cell Death Dis. 2016;7:e2108 pubmed 出版商
Koenig U, Fobker M, Lengauer B, Brandstetter M, Resch G, Gröger M, et al. Autophagy facilitates secretion and protects against degeneration of the Harderian gland. Autophagy. 2015;11:298-313 pubmed 出版商
Rossiter H, König U, Barresi C, Buchberger M, Ghannadan M, Zhang C, et al. Epidermal keratinocytes form a functional skin barrier in the absence of Atg7 dependent autophagy. J Dermatol Sci. 2013;71:67-75 pubmed 出版商
Zhao Y, Zhang C, Rossiter H, Eckhart L, König U, Karner S, et al. Autophagy is induced by UVA and promotes removal of oxidized phospholipids and protein aggregates in epidermal keratinocytes. J Invest Dermatol. 2013;133:1629-37 pubmed 出版商
Rausch V, Liu L, Apel A, Rettig T, Gladkich J, Labsch S, et al. Autophagy mediates survival of pancreatic tumour-initiating cells in a hypoxic microenvironment. J Pathol. 2012;227:325-35 pubmed 出版商
Tomek K, Wagner R, Varga F, Singer C, Karlic H, Grunt T. Blockade of fatty acid synthase induces ubiquitination and degradation of phosphoinositide-3-kinase signaling proteins in ovarian cancer. Mol Cancer Res. 2011;9:1767-79 pubmed 出版商
Yang J, Takahashi Y, Cheng E, Liu J, Terranova P, Zhao B, et al. GSK-3beta promotes cell survival by modulating Bif-1-dependent autophagy and cell death. J Cell Sci. 2010;123:861-70 pubmed 出版商
产品信息
目录号 :
GTX82986
产品名称 :
LC3B抗体
宿主物种 :
兔
克隆性 :
多克隆
产品类型 :
一抗
规格 :
100.00μl
标价 :
299美元
Pubmed号列表 :
21970855,22262369,20159967,23340736,23669018
产品描述 :
兔多克隆抗体LC3B
交叉活性 :
Hu, Ms
背景 :
Autophagy is a process of intracellular bulk degradation in which cytoplasmic components, including organelles, are sequestered within double-membrane vesicles that deliver the contents to the lysosome/vacuole for degradation. During macroautophagy, the sequestering vesicles, termed autophagosomes, fuse with the lysosome or vacuole resulting in the delivery of an inner vesicle (autophagic body) into the lumen of the degradative compartment. There are 16 proteins participating in the autophagy pathway in humans. The autophagy protein LC3, a mammalian homologue of Atg8, was originally identified as microtubule-associated protein 1 light chain 3. It is a component of both the MAP1A and MAP1B microtubule-binding domains and the heavy-chain independent regulation of LC3 expression may modify MAP1 microtubule-binding activity during development. LC3 is the only known mammalian protein identified that stably associates with the autophagosome membranes. LC3-I is cytosolic and LC3-II is membrane bound and enriched in the autophagic vacuole fraction. The detection of LC3-I to LC3-II conversion is a useful and sensitive marker for distinguishing autophagy in mammalian cells.
免疫原 :
Synthetic peptide - N-terminal region of the human LC3, isoform B protein
特异性 :
B isoform of LC3
缓冲液 :
三羟甲基氨基甲烷甘氨酸, 150mM氯化钠含0.05% 叠氮化钠
用途 :
FACS, ICC/IF, IHC, IHC-Fr, WB
浓度 :
1.47毫克/毫升
一般参考 :
Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid freeze-thaw cycles
图像Legend_4 :
Immunohistochemistry: LC3B Antibody [GTX82986] - LC3B staining in treated U87-MG cultured & subcutaneous tumors.
图像Legend_5 :
Immunohistochemistry: LC3B Antibody [GTX82986] - LC3B staining in gliobastoma multiform tissue.
图像Legend_6 :
Immunohistochemistry: LC3B Antibody [GTX82986] - Staining of treated U373-MG (human glioblastoma.
更多信息或购买 :
GeneTex 产品网页
公司信息
GeneTex
2456 Alton Pkwy
Irvine, CA92606
support@genetex.com
www.genetex.com
886-3-6208988
公司总部: 美国