产品简要
公司名称 :
HUABIO
产品类型 :
抗体
产品名称 :
CD3 zeta Rabbit Polyclonal Antibody (0805-7)
目录 :
0805-7
规格 :
多克隆
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
反应物种 :
人类
应用 :
免疫印迹, 免疫细胞化学, 流式细胞仪
更多信息或购买 :
产品信息
Catalog# :
0805-7
产品名称 :
CD3 zeta Rabbit Polyclonal Antibody (0805-7)
类别 :
Rabbit polyclonal primary
共轭 :
未共轭
克隆性 :
多克隆
宿主 :
兔
应用 :
免疫印迹, 免疫细胞化学, FC
应用w/稀释 :
WB: 1:1, 000;ICC: 1:500-1:2, 000;FC: 1:50-1:100
反应物种 :
人类
免疫原 :
Synthetic peptide within C-terminal Human CD3 zeta.
抗体亚型 :
IgG
靶蛋白 :
CD3 zeta
靶标.UniProt数据库 :
P20963
靶标.同义词 :
4930549J05Rik antibody; A430104F18Rik antibody; AW552088 antibody; CD247 antibody; CD247 antigen antibody; Cd247 molecule antibody; Cd3 antibody; CD3 antigen, zeta polypeptide, isoform CRA_b antibody; CD3 antigen, zeta subunit antibody; CD3-eta antibody; CD3H antibody; CD3Q antibody; Cd3z antibody; CD3Z antigen zeta polypeptide (TiT3 complex) antibody; CD3Z_HUMAN antibody; CD3zeta antibody; CD3zeta chain antibody; MGC140430 antibody; T cell receptor T3 zeta chain antibody; T cell surface glycoprotein CD3 zeta chain antibody; T-cell antigen receptor complex, zeta subunit of CD3 antibody; T-cell receptor T3 zeta chain antibody; T-cell surface glycoprotein CD3 zeta chain antibody; T3z antibody; TCR zeta chain antibody; TCRk antibody; TCRZ antibody; TCRzeta antibody
Target function/background :
Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. CD3Z ITAMs phosphorylation creates multiple docking sites for the protein kinase ZAP70 leading to ZAP70 phosphorylation and its conversion into a catalytically active enzyme. Plays an important role in intrathymic T-cell differentiation. Additionally, participates in the activity-dependent synapse formation of retinal ganglion cells (RGCs) in both the retina and dorsal lateral geniculate nucleus (dLGN).
产品形式 :
液体
纯化 :
肽亲和纯化
浓度 :
1微克/微升
储存缓冲液 :
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
储存空调 :
Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
分子量 :
19kDa
供应商 :
HUABIO
Volume :
100ul
价格 :
295
launch date :
2020&prior
更多信息或购买 :
公司信息
HUABIO
Founded in 2007, HUABIO is dedicated to developing high-quality antibodies that advance innovation. We are passionate about the accuracy, efficiency, and consistency of our products. That is why we have invested in new production platforms, like recombinant rabbit monoclonals, alpaca nanobodies, and adopted aggressive QA standards to deliver cutting-edge antibodies with uncompromised quality.
We hope to see you at your next discovery!
We hope to see you at your next discovery!