产品简要
公司名称 :
HUABIO
产品类型 :
抗体
产品名称 :
多聚(ADP-核糖)聚合酶小鼠单克隆抗体[A0-D11](EM1701-16)
目录 :
EM1701-16
规格 :
单克隆
价格 :
A0-D11
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
A0-D11
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫细胞化学, 流式细胞仪, 免疫组化-石蜡切片
更多信息或购买 :
HUABIO 产品网页
产品信息
Catalog# :
EM1701-16
产品名称 :
多聚(ADP-核糖)聚合酶小鼠单克隆抗体[A0-D11](EM1701-16)
类别 :
Mouse monoclonal primary
共轭 :
未共轭
克隆性 :
单克隆
克隆编号 :
A0-D11
宿主 :
小鼠
应用 :
免疫印迹, 免疫细胞化学, 免疫组化-P, FC
应用w/稀释 :
WB:1:500;ICC:1:50-1:100;免疫组化-P:1:100-1:500;FC:1:50-1:100
反应物种 :
人类, 小鼠, 大鼠
免疫原 :
多肽
抗体亚型 :
IgG1
靶蛋白 :
多聚(ADP-核糖)聚合酶
靶标.UniProt数据库 :
P09874
靶标.同义词 :
ADP ribosyltransferase (NAD+; poly (ADP ribose) polymerase) antibody; ADP ribosyltransferase antibody; ADP ribosyltransferase diphtheria toxin like 1 antibody; ADP ribosyltransferase NAD(+) antibody; ADPRT 1 antibody; ADPRT antibody; ADPRT1 antibody; ARTD1 antibody; msPARP antibody; NAD(+) ADP ribosyltransferase 1 antibody; NAD(+) ADP-ribosyltransferase 1 antibody; pADPRT 1 antibody; pADPRT1 antibody; PARP 1 antibody; PARP antibody; PARP-1 antibody; PARP1 antibody; PARP1_HUMAN antibody; Poly (ADP ribose) polymerase 1 antibody; poly (ADP ribose) polymerase family, member 1 antibody; Poly [ADP-ribose] polymerase 1 antibody; Poly(ADP ribose) polymerase antibody; poly(ADP ribose) synthetase antibody; poly(ADP ribosyl)transferase antibody; Poly[ADP ribose] synthetase 1 antibody; Poly[ADP-ribose] synthase 1 antibody; PPOL antibody
Target function/background :
Poly(ADP-ribose) polymerase-1 (PARP-1), also designated PARP, is a nuclear DNA-binding zinc finger protein that influences DNA repair, DNA replication, modulation of chromatin structure, and apoptosis. In response to genotoxic stress, PARP-1 catalyzes the transfer of ADP-ribose units from NAD(+) to a number of acceptor molecules including chromatin. PARP-1 recognizes DNA strand interruptions and can complex with RNA and negatively regulate transcription. Actinomycin D- and etoposide-dependent induction of caspases mediates cleavage of PARP-1 into a p89 fragment that traverses into the cytoplasm. Apoptosis-inducing factor (AIF) translocation from the mitochondria to the nucleus is PARP-1-dependent and is necessary for PARP-1-dependent cell death. PARP-1 deficiencies lead to chromosomal instability due to higher frequencies of chromosome fusions and aneuploidy, suggesting that poly(ADP-ribosyl)ation contributes to the efficient maintenance of genome integrity.
产品形式 :
液体
纯化 :
肽亲和纯化
浓度 :
2微克/微升
储存缓冲液 :
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
储存空调 :
Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
分子量 :
113 kDa
供应商 :
HUABIO
Volume :
100ul
价格 :
325
launch date :
2020&prior
更多信息或购买 :
HUABIO 产品网页
公司信息
HUABIO
Boston, Massachusetts
support@huabio.com
https://www.huabio.com
1-857-353-6600
公司总部: 美国
Founded in 2007, HUABIO is dedicated to developing high-quality antibodies that advance innovation. We are passionate about the accuracy, efficiency, and consistency of our products. That is why we have invested in new production platforms, like recombinant rabbit monoclonals, alpaca nanobodies, and adopted aggressive QA standards to deliver cutting-edge antibodies with uncompromised quality.
We hope to see you at your next discovery!