产品简要
公司名称 :
HUABIO
产品类型 :
抗体
产品名称 :
Bmi1小鼠单克隆抗体[A11-C11](EM1701-55)
目录 :
EM1701-55
规格 :
单克隆
价格 :
A11-C11
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
A11-C11
反应物种 :
人类
应用 :
免疫印迹, 免疫细胞化学, 免疫组化-石蜡切片
更多信息或购买 :
产品信息
Catalog# :
EM1701-55
产品名称 :
Bmi1小鼠单克隆抗体[A11-C11](EM1701-55)
类别 :
Mouse monoclonal primary
共轭 :
未共轭
克隆性 :
单克隆
克隆编号 :
A11-C11
宿主 :
小鼠
应用 :
免疫印迹, 免疫组化-P, 免疫细胞化学
应用w/稀释 :
WB: 1:500-1:1, 000;ICC:1:200;免疫组化-P:1:200-1:400
反应物种 :
人类, 小鼠
免疫原 :
重组蛋白
抗体亚型 :
IgG2a
靶蛋白 :
Bmi1
靶标.UniProt数据库 :
P35226
靶标.同义词 :
B lymphoma Mo MLV insertion region (mouse) antibody; B lymphoma Mo MLV insertion region 1 homolog antibody; Bmi 1 antibody; BMI1 antibody; BMI1 polycomb ring finger oncogene antibody; BMI1_HUMAN antibody; Flvi 2/bmi 1 antibody; FLVI2/BMI1 antibody; MGC12685 antibody; Murine leukemia viral (bmi 1) oncogene homolog antibody; Oncogene BMI 1 antibody; PCGF 4 antibody; PCGF4 antibody; Polycomb complex protein BMI 1 antibody; Polycomb complex protein BMI-1 antibody; Polycomb group protein Bmi1 antibody; Polycomb group ring finger 4 antibody; Polycomb group RING finger protein 4 antibody; RING finger protein 51 antibody; RNF 51 antibody; RNF51 antibody
Target function/background :
In Drosophila, Polycomb (Pc-g) gene family encodes chromatin proteins that are required for the repression of homeotic loci in embryonic development. Mel-18 and Bmi-1, mammalian homologs of Drosophila Pc-g group proteins, are similarly expressed during development and implicated in the regulation of gene expression, axial skeleton development, control of proliferation and survival of haematopoietic cells. Mel-18 directly binds to DNA through a RING-finger motif and preferentially associates with juxtaposed enhancer elements on various genes, including Bcl-2, c-Myc and Hox. Mel-18 is an immediate early response gene within the c-Myc/Cdc25 signaling cascade that exhibits tumor suppressor activity and negatively regulates cell cycle progression by blocking S phase entry. Alternatively, Bmi-1 has been identified as a potent oncogene as it contributes to the transcriptional activation of genes implicated in early lymphoid development. Proviral activation of Bmi-1 expression corresponds to enhanced gene-specific activation of other proto-oncogenes, including c-Myc and Pim, subsequently resulting in the progression of lymphomagenesis.
产品形式 :
液体
纯化 :
蛋白亲和纯化
浓度 :
2微克/微升
储存缓冲液 :
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
储存空调 :
Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
分子量 :
42 kDa
供应商 :
HUABIO
Volume :
100ul
价格 :
325
launch date :
2020&prior
更多信息或购买 :
公司信息
HUABIO
Founded in 2007, HUABIO is dedicated to developing high-quality antibodies that advance innovation. We are passionate about the accuracy, efficiency, and consistency of our products. That is why we have invested in new production platforms, like recombinant rabbit monoclonals, alpaca nanobodies, and adopted aggressive QA standards to deliver cutting-edge antibodies with uncompromised quality.
We hope to see you at your next discovery!
We hope to see you at your next discovery!