产品简要
公司名称 :
HUABIO
产品类型 :
抗体
产品名称 :
PKA C甲兔多克隆抗体(ER1706-65)
目录 :
ER1706-65
规格 :
多克隆
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫细胞化学, 流式细胞仪, 免疫组化-石蜡切片
更多信息或购买 :
产品信息
Catalog# :
ER1706-65
产品名称 :
PKA C甲兔多克隆抗体(ER1706-65)
类别 :
Rabbit polyclonal primary
共轭 :
未共轭
克隆性 :
多克隆
宿主 :
兔
应用 :
免疫细胞化学, 免疫组化-P, FC
应用w/稀释 :
ICC:1:50-1:200;免疫组化-P:1:50-1:200;FC:1:50-1:100
反应物种 :
人类, 小鼠, 大鼠
免疫原 :
Recombinant protein within human PKA C alpha aa 172-338.
抗体亚型 :
IgG
靶蛋白 :
PKA C甲
靶标.UniProt数据库 :
P17612
靶标.同义词 :
cAMP dependent protein kinase beta catalytic subunit antibody; cAMP dependent protein kinase alpha catalytic subunit antibody; cAMP dependent protein kinase catalytic subunit alpha antibody; cAMP dependent protein kinase catalytic subunit beta antibody; PKA C alpha antibody; PKA C beta antibody; PKACA antibody; PKACB antibody; PRKACA antibody; PRKACB antibody; Protein kinase cAMP dependent catalytic alpha antibody; Protein kinase cAMP dependent catalytic beta antibody
Target function/background :
The second messenger cyclic AMP (cAMP) mediates diverse cellular responses to external signals such as proliferation, ion transport, regulation of metabolism and gene transcription by activation of the cAMP-dependent protein kinase (cAPK or PKA). Activation of PKA occurs when cAMP binds to the two regulatory subunits of the tetrameric PKA holoenzyme resulting in release of active catalytic subunits. Three catalytic (C) subunits have been identified, designated Cα, Cβ and Cγ, that each represent specific gene products. Cα and Cβ are closely related (93% amino acid sequence similarity), whereas Cγ displays 83% and 79% similarity to Cα and Cβ, respectively. Activation of transcription upon elevation of cAMP levels results from translocation of PKA to the nucleus where it phosphorylates the transcription factor cAMP response element binding protein (CREB) on serine 133 which in turn leads to TFIIB binding to TATA-box-binding protein TBP1, thus linking phospho-CREB to the pol II transcription initiation complex.
产品形式 :
液体
纯化 :
蛋白亲和纯化
浓度 :
1微克/微升
储存缓冲液 :
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
储存空调 :
Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
分子量 :
40 kDa
供应商 :
HUABIO
Volume :
100ul
价格 :
295
launch date :
2020&prior
更多信息或购买 :
公司信息
HUABIO
Founded in 2007, HUABIO is dedicated to developing high-quality antibodies that advance innovation. We are passionate about the accuracy, efficiency, and consistency of our products. That is why we have invested in new production platforms, like recombinant rabbit monoclonals, alpaca nanobodies, and adopted aggressive QA standards to deliver cutting-edge antibodies with uncompromised quality.
We hope to see you at your next discovery!
We hope to see you at your next discovery!