产品简要
公司名称 :
HUABIO
产品类型 :
抗体
产品名称 :
TGF乙1兔多克隆抗体(ER31210)
目录 :
ER31210
规格 :
多克隆
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠, 斑马鱼
应用 :
免疫印迹, 免疫细胞化学, 流式细胞仪, 免疫组化-石蜡切片
更多信息或购买 :
产品信息
Catalog# :
ER31210
产品名称 :
TGF乙1兔多克隆抗体(ER31210)
类别 :
Rabbit polyclonal primary
共轭 :
未共轭
克隆性 :
多克隆
宿主 :
应用 :
免疫印迹, 免疫细胞化学, 免疫组化-P, FC
应用w/稀释 :
WB: 1:500-1:1, 000;ICC:1:200;免疫组化-P:1:200;FC:1:100
反应物种 :
人类, 小鼠, 大鼠, 斑马鱼
免疫原 :
Synthetic peptide (KLH-coupled) corresponding to Human TGF-Beta 1 C-terminal.
抗体亚型 :
IgG
靶蛋白 :
TGF乙1
靶标.UniProt数据库 :
P01137
靶标.同义词 :
Cartilage-inducing factor antibody; CED antibody; Differentiation inhibiting factor antibody; DPD1 antibody; LAP antibody; Latency-associated peptide antibody; Prepro transforming growth factor beta 1 antibody; TGF beta 1 antibody; TGF beta antibody; TGF beta 1 protein antibody; TGF-beta 1 protein antibody; TGF-beta-1 antibody; TGF-beta-5 antibody; TGF-beta1 antibody; TGFB antibody; Tgfb-1 antibody; tgfb1 antibody; TGFB1_HUMAN antibody; TGFbeta antibody; TGFbeta1 antibody; Transforming Growth Factor b1 antibody; Transforming Growth Factor beta 1 antibody; Transforming growth factor beta 1a antibody; transforming growth factor beta-1 antibody; transforming growth factor, beta 1 antibody; Transforming Growth Factor-ß1 antibody
Target function/background :
Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains remain non-covalently linked rendering TGF-beta-1 inactive during storage in extracellular matrix. At the same time, LAP chain interacts with 'milieu molecules', such as LTBP1, LRRC32/GARP and LRRC33/NRROS that control activation of TGF-beta-1 and maintain it in a latent state during storage in extracellular milieus. TGF-beta-1 is released from LAP by integrins (ITGAV:ITGB6 or ITGAV:ITGB8): integrin-binding to LAP stabilizes an alternative conformation of the LAP bowtie tail and results in distortion of the LAP chain and subsequent release of the active TGF-beta-1. Once activated following release of LAP, TGF-beta-1 acts by binding to TGF-beta receptors (TGFBR1 and TGFBR2), which transduce signal (PubMed:20207738).
产品形式 :
液体
纯化 :
肽亲和纯化
浓度 :
1微克/微升
储存缓冲液 :
1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
储存空调 :
Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
分子量 :
44 kDa
供应商 :
HUABIO
Volume :
100ul
价格 :
295
launch date :
2020&prior
更多信息或购买 :
公司信息
HUABIO
Boston, Massachusetts
support@huabio.com
https://www.huabio.com
1-857-353-6600
公司总部: 美国
Founded in 2007, HUABIO is dedicated to developing high-quality antibodies that advance innovation. We are passionate about the accuracy, efficiency, and consistency of our products. That is why we have invested in new production platforms, like recombinant rabbit monoclonals, alpaca nanobodies, and adopted aggressive QA standards to deliver cutting-edge antibodies with uncompromised quality.
We hope to see you at your next discovery!