产品简要
公司名称 :
HUABIO
产品类型 :
抗体
产品名称 :
Bcl-2 Recombinant Rabbit Monoclonal Antibody [SZ10-03] (ET1603-11)
目录 :
ET1603-11
规格 :
单克隆
价格 :
SZ10-03
克隆性 :
单克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
克隆名称 :
SZ10-03
反应物种 :
丝蛾, 人类, 小鼠
应用 :
免疫印迹, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 免疫组化-石蜡切片
更多信息或购买 :
HUABIO 产品网页
文章摘录数: 2
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 人类
Yang Y, Liang Z, Xia Z, Wang X, Ma Y, Sheng Z, et al. SAE1 promotes human glioma progression through activating AKT SUMOylation-mediated signaling pathways. Cell Commun Signal. 2019;17:82 pubmed 出版商
  • 免疫印迹; 丝蛾
Li X, Xie H, Chen Y, Lang M, Chen Y, Shi L. Silkworm Pupa Protein Hydrolysate Induces Mitochondria-Dependent Apoptosis and S Phase Cell Cycle Arrest in Human Gastric Cancer SGC-7901 Cells. Int J Mol Sci. 2018;19: pubmed 出版商
产品信息
Catalog# :
ET1603-11
产品名称 :
Bcl-2 Recombinant Rabbit Monoclonal Antibody [SZ10-03] (ET1603-11)
类别 :
Recombinant Rabbit monoclonal primary
共轭 :
未共轭
克隆性 :
单克隆
克隆编号 :
SZ10-03
宿主 :
兔
应用 :
免疫印迹, 免疫细胞化学, IF, 免疫组化-P, 免疫沉淀, FC
应用w/稀释 :
WB: 1:1, 000-1:2, 000;免疫细胞化学/IF:1:50-1:200;免疫组化-P:1:50-1:500;FC:1:50-1:100;IP:依实验方法而定
反应物种 :
人类, 小鼠
免疫原 :
Synthetic peptide within human Bcl-2 aa 40-90.
抗体亚型 :
IgG
靶蛋白 :
Bcl-2
靶标.UniProt数据库 :
P10415
靶标.同义词 :
Apoptosis regulator Bcl 2 antibody; Apoptosis regulator Bcl-2 antibody; Apoptosis regulator Bcl2 antibody; AW986256 antibody; B cell CLL/lymphoma 2 antibody; B cell leukemia/lymphoma 2 antibody; Bcl-2 antibody; Bcl2 antibody; BCL2_HUMAN antibody; C430015F12Rik antibody; D630044D05Rik antibody; D830018M01Rik antibody; Leukemia/lymphoma, B-cell, 2 antibody; Oncogene B-cell leukemia 2 antibody; PPP1R50 antibody; Protein phosphatase 1, regulatory subunit 50 antibody
Target function/background :
Apoptosis is defined as a set of cascades which, when initiated, programs the cell to undergo lethal changes such as membrane blebbing, mitochondrial break down and DNA fragmentation. Bcl-2 is one among many key regulators of apoptosis, which are essential for proper development, tissue homeostasis, and protection against foreign pathogens. Human Bcl-2 is an anti-apoptotic, membrane-associated oncoprotein that can promote cell survival through protein-protein interactions with other Bcl-2 related family members, such as the death suppressors Bcl-xl, Mcl-1, Bcl-w, and A1 or the death agonists Bax, Bak, Bik, Bad, and Bid. The anti-apoptotic function of Bcl-2 can also be regulated through proteolytic processing and phospho-rylation. Bcl-2 may promote cell survival by interfering with the activation of the cytochrome c/Apaf-1 pathway through stabilization of the mitochondrial membrane. Mutations in the Bcl-2 gene can contribute to cancers where normal physiological cell death mechanisms are compromised by deregulation of the anti-apoptotic influence of Bcl-2.
产品形式 :
液体
纯化 :
蛋白质A亲和纯化
浓度 :
1微克/微升
储存缓冲液 :
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
储存空调 :
Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
分子量 :
26/22 kDa
供应商 :
HUABIO
Volume :
100ul
价格 :
359
launch date :
2020&prior
更多信息或购买 :
HUABIO 产品网页
公司信息
HUABIO
Boston, Massachusetts
support@huabio.com
https://www.huabio.com
1-857-353-6600
公司总部: 美国
Founded in 2007, HUABIO is dedicated to developing high-quality antibodies that advance innovation. We are passionate about the accuracy, efficiency, and consistency of our products. That is why we have invested in new production platforms, like recombinant rabbit monoclonals, alpaca nanobodies, and adopted aggressive QA standards to deliver cutting-edge antibodies with uncompromised quality.
We hope to see you at your next discovery!