产品简要
公司名称 :
HUABIO
产品类型 :
抗体
产品名称 :
磷酸化Erk1(T202)+Erk2(T185)重组兔单克隆抗体[SZ2-4](ET1603-22)
目录 :
ET1603-22
规格 :
单克隆
价格 :
SZ2-4
克隆性 :
单克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
抗原修饰 :
磷酸化
克隆名称 :
SZ2-4
反应物种 :
人类
应用 :
免疫印迹, 免疫细胞化学, 流式细胞仪, 免疫组化-石蜡切片
更多信息或购买 :
HUABIO 产品网页
产品信息
Catalog# :
ET1603-22
产品名称 :
磷酸化Erk1(T202)+Erk2(T185)重组兔单克隆抗体[SZ2-4](ET1603-22)
类别 :
Recombinant Rabbit monoclonal primary
共轭 :
未共轭
克隆性 :
单克隆
克隆编号 :
SZ2-4
宿主 :
兔
应用 :
免疫印迹, 免疫细胞化学, 免疫组化-P, FC
应用w/稀释 :
WB: 1:1, 000;ICC:1:100-1:500;免疫组化-P:1:50-1:200;FC:1:50-1:100
反应物种 :
人类
免疫原 :
Synthetic phospho-peptide corresponding to residues surrounding Thr202 of human Erk1.
抗体亚型 :
IgG
靶蛋白 :
磷酸化Erk1(T202)+Erk2(T185)
靶标.UniProt数据库 :
P27361
靶标.同义词 :
ERK 1 antibody; ERK 2 antibody; ERK-1 antibody; ERK-2 antibody; ERK1 antibody; erk1/2 antibody; ERK2 antibody; ERT1 antibody; ERT2 antibody; Extracellular signal regulated kinase 1 antibody; Extracellular signal-regulated kinase 1 antibody; Extracellular signal-regulated kinase 2 antibody; HS44KDAP antibody; HUMKER1A antibody; Insulin-stimulated MAP2 kinase antibody; MAP kinase 1 antibody; MAP kinase 2 antibody; MAP kinase 3 antibody; MAP kinase isoform p42 antibody; MAP kinase isoform p44 antibody; MAPK 1 antibody; MAPK 2 antibody; MAPK 3 antibody; Mapk1 antibody; MAPK2 antibody; MAPK3 antibody; Microtubule-associated protein 2 kinase antibody; Mitogen-activated protein kinase 1 antibody; Mitogen-activated protein kinase 2 antibody; Mitogen-activated protein kinase 3 antibody; MK01_HUMAN antibody; p38 antibody; p40 antibody; p41 antibody; p41mapk antibody; p42-MAPK antibody; P42MAPK antibody; p44-ERK1 antibody; p44-MAPK antibody; p44ERK1 antibody; p44MAPK antibody; PRKM 2 antibody; PRKM1 antibody; PRKM2 antibody; PRKM3 antibody; protein tyrosine kinase ERK2 antibody
Target function/background :
Mitogen-activated protein kinases (MAPKs) are a widely conserved family of serine/threonine protein kinases involved in many cellular programs, such as cell proliferation, differentiation, motility, and death. The p44/42 MAPK (Erk1/2) signaling pathway can be activated in response to a diverse range of extracellular stimuli including mitogens, growth factors, and cytokines, and research investigators consider it an important target in the diagnosis and treatment of cancer. Upon stimulation, a sequential three-part protein kinase cascade is initiated, consisting of a MAP kinase kinase kinase (MAPKKK or MAP3K), a MAP kinase kinase (MAPKK or MAP2K), and a MAP kinase (MAPK). Multiple p44/42 MAP3Ks have been identified, including members of the Raf family, as well as Mos and Tpl2/COT. MEK1 and MEK2 are the primary MAPKKs in this pathway. MEK1 and MEK2 activate p44 and p42 through phosphorylation of activation loop residues Thr202/Tyr204 and Thr185/Tyr187, respectively. Several downstream targets of p44/42 have been identified, including p90RSK and the transcription factor Elk-1. p44/42 are negatively regulated by a family of dual-specificity (Thr/Tyr) MAPK phosphatases, known as DUSPs or MKPs, along with MEK inhibitors, such as U0126 and PD98059.
产品形式 :
液体
纯化 :
蛋白质A亲和纯化
浓度 :
1微克/微升
储存缓冲液 :
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
储存空调 :
Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
分子量 :
43/41 kDa
供应商 :
HUABIO
Volume :
100ul
价格 :
355
launch date :
2020&prior
更多信息或购买 :
HUABIO 产品网页
公司信息
HUABIO
Boston, Massachusetts
support@huabio.com
https://www.huabio.com
1-857-353-6600
公司总部: 美国
Founded in 2007, HUABIO is dedicated to developing high-quality antibodies that advance innovation. We are passionate about the accuracy, efficiency, and consistency of our products. That is why we have invested in new production platforms, like recombinant rabbit monoclonals, alpaca nanobodies, and adopted aggressive QA standards to deliver cutting-edge antibodies with uncompromised quality.
We hope to see you at your next discovery!