抗体

GSK3乙重组兔单克隆抗体[SY28-03](ET1607-71)

ET1607-71

单克隆

SY28-03

单克隆

domestic rabbit

未共轭

SY28-03

人类, 小鼠

免疫印迹, 免疫细胞化学, 流式细胞仪, 免疫组化-石蜡切片

GSK3乙重组兔单克隆抗体[SY28-03](ET1607-71)

Recombinant Rabbit monoclonal primary

未共轭

单克隆

SY28-03

兔

免疫印迹, 免疫细胞化学, IF, 免疫组化-P, FC

WB: 1:1, 000-1:2, 000;免疫细胞化学/IF:1:50-1:200;免疫组化-P:1:50-1:200;FC:1:50-1:100

人类, 小鼠

Synthetic peptide within human GSK3 beta aa 360-400.

IgG

GSK3乙

P49841

Glycogen Synthase Kinase 3 Beta antibody; Glycogen synthase kinase-3 beta antibody; GSK 3 beta antibody; GSK-3 beta antibody; GSK3B antibody; GSK3B_HUMAN antibody; GSK3beta isoform antibody; Serine/threonine-protein kinase GSK3B antibody

Glycogen synthase kinase 3, or GSK-3, is a serine/threonine, proline-directed kinase involved in a diverse array of signaling pathways, including glycogen synthesis and cellular adhesion, and has been implicated in Alzheimer’s disease. Two forms of GSK-3, designated GSK-3α and GSK-3β, have been identified and differ in their subcellular localization. Tau, a microtubule-binding protein which serves to stabilize microtubules in growing axons, is found to be hyper-phosphorylated in paired helical filaments (PHF), the major fibrous component of neurofibrillary lesions associated with Alzheimer’s disease. Hyperphosphorylation of Tau is thought to be the critical event leading to the assembly of PHF. Six Tau protein isoforms have been identified, all of which are phosphorylated by GSK-3. This presents the possibility that miscues in GSK-3 signaling contribute to the onset of Alzheimer’s disease.

液体

蛋白质A亲和纯化

1微克/微升

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.

47 kDa

HUABIO

100ul

355

2020&prior