产品简要
公司名称 :
HUABIO
产品类型 :
抗体
产品名称 :
切断的PARP重组兔单克隆抗体[SU0314](ET1608-10)
目录 :
ET1608-10
规格 :
单克隆
价格 :
SU0314
克隆性 :
单克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
克隆名称 :
SU0314
反应物种 :
人类
应用 :
免疫印迹, 免疫细胞化学, 免疫沉淀, 流式细胞仪
更多信息或购买 :
HUABIO 产品网页
文章摘录数: 1
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 人类
Liu X, Peng J, Zhou Y, Xie B, Wang J. Silencing RRM2 inhibits multiple myeloma by targeting the Wnt/β‑catenin signaling pathway. Mol Med Rep. 2019;20:2159-2166 pubmed 出版商
产品信息
Catalog# :
ET1608-10
产品名称 :
切断的PARP重组兔单克隆抗体[SU0314](ET1608-10)
类别 :
Recombinant Rabbit monoclonal primary
共轭 :
未共轭
克隆性 :
单克隆
克隆编号 :
SU0314
宿主 :
兔
应用 :
免疫印迹, 免疫细胞化学, 免疫沉淀, FC
应用w/稀释 :
WB: 1:1, 000-1:2, 000;FC: 1:50-1:100;ICC: 1:50-1:200
反应物种 :
人类
免疫原 :
Synthetic peptide within human PARP1 aa 210-250.
抗体亚型 :
IgG
靶蛋白 :
切断的PARP
靶标.UniProt数据库 :
P09874
靶标.同义词 :
ADP-ribosyltransferase diphtheria toxin-like 1 antibody; ADPRT 1 antibody; ADPRT antibody; ADPRT1 antibody; APOPAIN antibody; ARTD1 antibody; NAD(+) ADP-ribosyltransferase 1 antibody; PARP antibody; PARP-1 antibody; PARP1 antibody; PARP1_HUMAN antibody; Poly [ADP-ribose] polymerase 1 antibody; Poly ADP ribose polymerase 1 antibody; Poly[ADP-ribose] synthase 1 antibody; PPOL antibody; SCA1 antibody
Target function/background :
Poly(ADP-ribose) polymerase-1 (PARP-1), also designated PARP, is a nuclear DNA-binding zinc finger protein that influences DNA repair, DNA replication, modulation of chromatin structure, and apoptosis. In response to genotoxic stress, PARP-1 catalyzes the transfer of ADP-ribose units from NAD(+) to a number of acceptor molecules including chromatin. PARP-1 recognizes DNA strand interruptions and can complex with RNA and negatively regulate transcription. Actinomycin D- and etoposide-dependent induction of caspases mediates cleavage of PARP-1 into a p89 fragment that traverses into the cytoplasm. Apoptosis-inducing factor (AIF) translocation from the mitochondria to the nucleus is PARP-1-dependent and is necessary for PARP-1-dependent cell death. PARP-1 deficiencies lead to chromosomal instability due to higher frequencies of chromosome fusions and aneuploidy, suggesting that poly(ADP-ribosyl)ation contributes to the efficient maintenance of genome integrity. This antibody recognizes the apoptosis-specific 89 kDa catalytic domain fragment, but it does not recognize the full-length PARP-1 or the 24 kDa DNA binding domain fragment.
产品形式 :
液体
纯化 :
蛋白质A亲和纯化
浓度 :
1微克/微升
储存缓冲液 :
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
储存空调 :
Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
分子量 :
89 kDa
供应商 :
HUABIO
Volume :
100ul
价格 :
355
launch date :
2020&prior
更多信息或购买 :
HUABIO 产品网页
公司信息
HUABIO
Boston, Massachusetts
support@huabio.com
https://www.huabio.com
1-857-353-6600
公司总部: 美国
Founded in 2007, HUABIO is dedicated to developing high-quality antibodies that advance innovation. We are passionate about the accuracy, efficiency, and consistency of our products. That is why we have invested in new production platforms, like recombinant rabbit monoclonals, alpaca nanobodies, and adopted aggressive QA standards to deliver cutting-edge antibodies with uncompromised quality.
We hope to see you at your next discovery!