产品简要
公司名称 :
HUABIO
产品类型 :
抗体
产品名称 :
AKT1/2/3重组兔单克隆抗体[ST48-09](ET1609-51)
目录 :
ET1609-51
规格 :
单克隆
价格 :
ST48-09
克隆性 :
单克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
克隆名称 :
ST48-09
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 免疫组化-石蜡切片
更多信息或购买 :
文章摘录数: 2
出版应用/物种/样本/稀释参考文献
  • 免疫细胞化学; 人类
  • 免疫印迹; 人类
Yin J, Zhang H, Wu X, Zhang Y, Li J, Shen J, et al. CD44 inhibition attenuates EGFR signaling and enhances cisplatin sensitivity in human EGFR wild‑type non‑small‑cell lung cancer cells. Int J Mol Med. 2020;45:1783-1792 pubmed 出版商
  • 免疫印迹; 人类
Gao B, Zhao L, Wang F, Bai H, Li J, Li M, et al. Knockdown of ISOC1 inhibits the proliferation and migration and induces the apoptosis of colon cancer cells through the AKT/GSK-3β pathway. Carcinogenesis. 2019;: pubmed 出版商
产品信息
Catalog# :
ET1609-51
产品名称 :
AKT1/2/3重组兔单克隆抗体[ST48-09](ET1609-51)
类别 :
Recombinant Rabbit monoclonal primary
共轭 :
未共轭
克隆性 :
单克隆
克隆编号 :
ST48-09
宿主 :
应用 :
免疫印迹, 免疫细胞化学, IF, 免疫组化-P, 免疫沉淀, FC
应用w/稀释 :
WB: 1:1, 000-1:5, 000;免疫细胞化学/IF:1:50-1:200;免疫组化-P:1:50-1:200;FC:1:50-1:100
反应物种 :
人类, 小鼠, 大鼠
免疫原 :
Recombinant protein within human AKT3 aa 300-479.
抗体亚型 :
IgG
靶蛋白 :
AKT1/2/3
靶标.UniProt数据库 :
P31749
靶标.同义词 :
AKT antibody; AKT1 antibody; AKT1 kinase antibody; AKT1m antibody; AKT2 antibody; AKT2 kinase antibody; Akt3 antibody; AKT3_HUMAN antibody; CAKT antibody; CWS6 antibody; DKFZp434N0250 antibody; HIHGHH antibody; kinase Akt1 antibody; MGC99656 antibody; MPPH antibody; Murine thymoma viral (v-akt) homolog 2 antibody; PKB ALPHA antibody; PKB antibody; PKB beta antibody; PKB gamma antibody; PKB-GAMMA antibody; PKB/Akt antibody; PKBALPHA antibody; PKBB antibody; PKBBETA antibody; PKBG antibody; PKBGAMMA antibody; PRKBA antibody; PRKBB antibody; PRKBG antibody; Protein kinase Akt 2 antibody; Protein kinase Akt-3 antibody; Protein kinase B alpha antibody; Protein kinase B antibody; Protein kinase B beta antibody; Protein kinase B gamma antibody; Proto oncogene c Akt antibody; RAC ALPHA antibody; RAC alpha serine/threonine protein kinase antibody; RAC antibody; RAC BETA antibody; RAC beta serine/threonine protein kinase antibody; RAC PK alpha antibody; RAC PK beta antibody; rac protein kinase alpha antibody; rac protein kinase beta antibody; RAC-gamma antibody; RAC-gamma serine/threonine-protein kinase antibody; RAC-PK-gamma antibody; RACALPHA antibody; RACalpha serine/threonine kinase antibody; RACBETA antibody; RACgamma antibody; RACgamma serine/threonine protein kinase antibody; RACPKgamma antibody; serine threonine protein kinase antibody; STK-2 antibody; STK2 antibody; thymoma viral proto oncogene 1 antibody; thymoma viral proto oncogene antibody; V akt murine thymoma viral oncogene homolog 1 antibody; V akt murine thymoma viral oncogene homolog 2 antibody; V akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) antibody; V akt murine thymoma viral oncogene homolog 3 antibody; vakt murine thymoma viral oncogene homolog 1 antibody; vakt murine thymoma viral oncogene homolog 2 antibody; vakt murine thymoma viral oncogene homolog 3 antibody
Target function/background :
The serine/threonine kinase Akt family contains several members, including Akt1 (also designated PKB or RacPK), Akt2 (also designated PKBβ or RacPK-β) and Akt 3 (also designated PKBγ or thyoma viral proto-oncogene 3), which exhibit sequence homology with the protein kinase A and C families and are encoded by the c-Akt proto-oncogene. All members of the Akt family have a pleckstrin homology domain. Akt1 and Akt2 are activated by PDGF stimulation. This activation is dependent on PDGFR-β tyrosine residues 740 and 751, which bind the subunit of the phosphatidylinositol 3-kinase (PI 3-kinase) complex. Activation of Akt1 by insulin or insulin-growth factor-1(IGF-1) results in phosphorylation of both Thr 308 and Ser 473. Phosphorylation of both residues is important to generate a high level of Akt1 activity, and the phosphorylation of Thr 308 is not dependent on phosphorylation of Ser 473 in vivo. Thus, Akt proteins become phosphorylated and activated in insulin/IGF-1-stimulated cells by an upstream kinase(s). The activation of Akt1 and Akt2 is inhibited by the PI kinase inhibitor wortmannin, suggesting that the protein signals downstream of the PI kinases.
产品形式 :
液体
纯化 :
蛋白质A亲和纯化
浓度 :
1微克/微升
储存缓冲液 :
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
储存空调 :
Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
分子量 :
56 kDa
供应商 :
HUABIO
Volume :
100ul
价格 :
355
launch date :
2020&prior
更多信息或购买 :
公司信息
HUABIO
Boston, Massachusetts
support@huabio.com
https://www.huabio.com
1-857-353-6600
公司总部: 美国
Founded in 2007, HUABIO is dedicated to developing high-quality antibodies that advance innovation. We are passionate about the accuracy, efficiency, and consistency of our products. That is why we have invested in new production platforms, like recombinant rabbit monoclonals, alpaca nanobodies, and adopted aggressive QA standards to deliver cutting-edge antibodies with uncompromised quality.
We hope to see you at your next discovery!