产品简要
公司名称 :
HUABIO
产品类型 :
抗体
产品名称 :
p73重组兔单克隆抗体[ST05-76](ET1609-80)
目录 :
ET1609-80
规格 :
单克隆
价格 :
ST05-76
克隆性 :
单克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
克隆名称 :
ST05-76
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 免疫细胞化学, 免疫组化-石蜡切片
更多信息或购买 :
HUABIO 产品网页
产品信息
Catalog# :
ET1609-80
产品名称 :
p73重组兔单克隆抗体[ST05-76](ET1609-80)
类别 :
Recombinant Rabbit monoclonal primary
共轭 :
未共轭
克隆性 :
单克隆
克隆编号 :
ST05-76
宿主 :
兔
应用 :
免疫印迹, 免疫细胞化学, IF, 免疫组化-P
应用w/稀释 :
WB: 1:1, 000;免疫细胞化学/IF:1:50-1:200;免疫组化-P:1:50-1:200
反应物种 :
人类, 小鼠
免疫原 :
重组蛋白
抗体亚型 :
IgG
靶蛋白 :
p73
靶标.UniProt数据库 :
O15350
靶标.同义词 :
p53 like transcription factor antibody; p53 related protein antibody; p53-like transcription factor antibody; p53-related protein antibody; p73 antibody; P73_HUMAN antibody; TP73 antibody; Tumor protein p73 antibody
Target function/background :
The p53 gene is a widely studied anti-oncogene, or tumor suppressor gene. The p53 gene product can act as a negative regulator of cell growth in response to DNA damage. Mutations and allelic loss of the p53 gene have been associated with malignant transformation in a wide variety of human tumors. p53 shares considerable sequence similarity with p73, a gene that maps to a region in chromosome 1 that is frequently deleted in neuroblastomas. However, p73 does not appear to be activated by DNA damaging agents. The p73 isoform p73α inhibits drug-induced apoptosis in small cell lung carcinoma cells, while the p73 isoform p73β promotes it. p73α also prevents Bax activation, mitochondrial dysfunction, caspase activation and is able to reduce apoptosis induced by the BH3-only protein PUMA (p53 upregulated modulator of apoptosis). There is an equilibrium between p73α and p73β, demonstrated by the fact that p73α inhibits the pro-apoptotic effect of p73β.
产品形式 :
液体
纯化 :
蛋白质A亲和纯化
浓度 :
1微克/微升
储存缓冲液 :
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
储存空调 :
Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
分子量 :
70 kDa(12 isoforms)
供应商 :
HUABIO
Volume :
100ul
价格 :
355
launch date :
2020&prior
更多信息或购买 :
HUABIO 产品网页
公司信息
HUABIO
Boston, Massachusetts
support@huabio.com
https://www.huabio.com
1-857-353-6600
公司总部: 美国
Founded in 2007, HUABIO is dedicated to developing high-quality antibodies that advance innovation. We are passionate about the accuracy, efficiency, and consistency of our products. That is why we have invested in new production platforms, like recombinant rabbit monoclonals, alpaca nanobodies, and adopted aggressive QA standards to deliver cutting-edge antibodies with uncompromised quality.
We hope to see you at your next discovery!