抗体

STAT5a重组兔单克隆抗体[SC66-09](ET1610-58)

ET1610-58

单克隆

SC66-09

单克隆

domestic rabbit

未共轭

SC66-09

人类, 小鼠, 大鼠

免疫印迹, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 免疫组化-石蜡切片

STAT5a重组兔单克隆抗体[SC66-09](ET1610-58)

Recombinant Rabbit monoclonal primary

未共轭

单克隆

SC66-09

兔

免疫印迹, 免疫细胞化学, IF, 免疫组化-P, 免疫沉淀, FC

WB: 1:1, 000-1:2, 000;免疫细胞化学/IF:1:50-1:200;免疫组化-P:1:50-1:200;FC:1:50-1:100

人类, 小鼠, 大鼠

Synthetic peptide within C-terminal human STAT5a.

IgG

STAT5a

P42229

Mammary gland factor antibody; MGF antibody; Signal transducer and activator of transcription 5A antibody; STA5A_HUMAN antibody; STAT 5 antibody; STAT 5A antibody; STAT5 antibody; STAT5A antibody

Signal transducer and activator of transcription 5A (Stat5a) and Stat5b, which share 96% homology, undergo receptor tyrosine kinase or G protein-coupled receptor-dependent phosphorylation in response to cytokines or growth factors, and then form homo- or heterodimers that translocate to the nucleus, where they initiate transcription. Activation of Stat5a via IL-2, IL-3, IL-7/ GM-CSF, erythropoietin, thrombopoietin and growth hormones influences proliferation, differentiation and apoptosis in lymphohematopoietic cells. Phos-phorylation of Stat5a at Ser127/Ser128 and Ser779 are contigent on ErbB-4-mediated activation of Stat5a. Activation of Stat5b via IL-2, IL-4, CSF-1 and growth hormones influences TCR signaling, apoptosis, adult mammary gland development and sexual dimorphism of liver gene expression. Stat5b is the major liver-expressed Stat5 form that has been shown to fuse with the retin-oic acid receptor a gene in acute promyelocytic leukemias (APLL). Stat5a/b null mice have severely impaired lymphoid development and differentiation.

液体

蛋白质A亲和纯化

1微克/微升

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.

91 kDa

HUABIO

100ul

355

2020&prior