产品简要
公司名称 :
HUABIO
产品类型 :
抗体
产品名称 :
血管紧张素ii类型2受体重组兔单克隆抗体[SN71-03](ET1611-41)
目录 :
ET1611-41
规格 :
单克隆
价格 :
SN71-03
克隆性 :
单克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
克隆名称 :
SN71-03
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫沉淀
更多信息或购买 :
产品信息
Catalog# :
ET1611-41
产品名称 :
血管紧张素ii类型2受体重组兔单克隆抗体[SN71-03](ET1611-41)
类别 :
Recombinant Rabbit monoclonal primary
共轭 :
未共轭
克隆性 :
单克隆
克隆编号 :
SN71-03
宿主 :
兔
应用 :
免疫印迹, 免疫沉淀
应用w/稀释 :
WB: 1:1, 000-1:2, 000
反应物种 :
人类, 小鼠, 大鼠
免疫原 :
Synthetic peptide within C-terminal human Angiotensin II Type 2 Receptor.
抗体亚型 :
IgG
靶蛋白 :
血管紧张素ii类型2受体
靶标.UniProt数据库 :
P50052
靶标.同义词 :
AGTR 2抗体;Agtr2抗体;AGTR2_HUMAN抗体;血管紧张素Ⅱ受体类型2抗体;血管紧张素ii类型2受体抗体;血管紧张素受体2抗体;AT 2抗体;AT2抗体;ATGR 2抗体;ATGR2抗体;MRX 88抗体;MRX88抗体;类型2血管紧张素Ⅱ受体抗体;类型2血管紧张素Ⅱ受体抗体
Target function/background :
Angiotensin II (Ang II) is an important physiological effector of blood pressure and volume regulation through vasoconstriction, aldosterone release, sodium uptake and thirst stimulation. Although Ang II interacts with two types of cell surface receptors, AT1 and AT2, most of the major cardiovascular effects seem to be mediated through AT1. Molecular cloning of the AT1 protein has shown it to be a member of the G protein-associated seven transmembrane protein receptor family. Ang II treatment of cells results in activation of several signal transduction pathways as evidenced by tyrosine phosphorylation of several proteins and induction of others. PLCγ is phosphorylated after 30 seconds of treatment with Angiotensin II, indicating this as an early signal transduction event. Ang II treatment also stimulates phosphorylation of Shc, FAK and MAP kinases, and induces MKP-1, indicating stimulation of growth factor pathways. Ang II stimulation through AT1 has been shown to activate the JAK/Stat pathway involving a direct interaction between JAK2 and AT1 as demonstrated by coimmunoprecipitation. The AT1 receptor has no cytoplasmic kinase domain, but is able to function as a substrate for Src kinases and has several putative phosphorylation sites.
产品形式 :
液体
纯化 :
蛋白质A亲和纯化
浓度 :
1微克/微升
储存缓冲液 :
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
储存空调 :
Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
分子量 :
41 kDa
供应商 :
HUABIO
Volume :
100ul
价格 :
355
launch date :
2020&prior
更多信息或购买 :
公司信息
HUABIO
Founded in 2007, HUABIO is dedicated to developing high-quality antibodies that advance innovation. We are passionate about the accuracy, efficiency, and consistency of our products. That is why we have invested in new production platforms, like recombinant rabbit monoclonals, alpaca nanobodies, and adopted aggressive QA standards to deliver cutting-edge antibodies with uncompromised quality.
We hope to see you at your next discovery!
We hope to see you at your next discovery!