产品简要
公司名称 :
HUABIO
产品类型 :
抗体
产品名称 :
TrkA+B+C Recombinant Rabbit Monoclonal Antibody [JJ084-04] (ET1701-16)
目录 :
ET1701-16
规格 :
单克隆
价格 :
JJ084-04
克隆性 :
单克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
克隆名称 :
JJ084-04
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫细胞化学, 免疫组化-石蜡切片
更多信息或购买 :
HUABIO 产品网页
产品信息
Catalog# :
ET1701-16
产品名称 :
TrkA+B+C Recombinant Rabbit Monoclonal Antibody [JJ084-04] (ET1701-16)
类别 :
Recombinant Rabbit monoclonal primary
共轭 :
未共轭
克隆性 :
单克隆
克隆编号 :
JJ084-04
宿主 :
兔
应用 :
免疫印迹, 免疫细胞化学, 免疫组化-P
应用w/稀释 :
WB: 1:1, 000-1:5, 000;ICC:1:50-1:200;免疫组化-P:1:50-1:200
反应物种 :
人类, 小鼠, 大鼠
免疫原 :
重组蛋白
抗体亚型 :
IgG
靶蛋白 :
TrkA+B+C
靶标.UniProt数据库 :
P04629
靶标.同义词 :
BDNF/NT-3 growth factors receptor antibody; gp140trk antibody; GP145-TrkB antibody; GP145-TrkC antibody; High affinity nerve growth factor receptor antibody; MTC antibody; Neurotrophic tyrosine kinase receptor type 1 antibody; Neurotrophic tyrosine kinase receptor type 2 antibody; Neurotrophic tyrosine kinase receptor type 3 antibody; NT-3 growth factor receptor antibody; NTRK1 antibody; NTRK2 antibody; NTRK3 antibody; p140-TrkA antibody; TRK antibody; Trk-A antibody; Trk-B antibody; Trk-C antibody; TRK1-transforming tyrosine kinase protein antibody; TRKA antibody; TRKB antibody; TrkB tyrosine kinase antibody; TRKC antibody; TrkC tyrosine kinase antibody; Tropomyosin-related kinase A antibody; Tropomyosin-related kinase B antibody; Tyrosine kinase receptor A antibody; Tyrosine kinase receptor antibody
Target function/background :
The family of Trk receptor tyrosine kinases consists of TrkA, TrkB, and TrkC. While the sequence of these family members is highly conserved, they are activated by different neurotrophins: TrkA by NGF, TrkB by BDNF or NT4, and TrkC by NT3. In the adult nervous system, the Trk receptors regulate synaptic strength and plasticity. TrkA regulates proliferation and is important for development and maturation of the nervous system. Point mutations, deletions, and chromosomal rearrangements (chimeras) cause ligand-independent receptor dimerization and activation of TrkA. TrkA is activated in many malignancies including breast, ovarian, prostate, and thyroid carcinomas. TrkB is overexpressed in tumors such as neuroblastoma, prostate adenocarcinoma and pancreatic ductal adenocarcinoma. In neuroblastomas overexpression of TrkB correlates with unfavorable disease outcome when autocrine loops signaling tumor survival are potentiated by additional overexpression of brain-derived neurotrophic factor (BDNF). An alternatively spliced truncated TrkB isoform lacking the kinase domain is overexpressed in Wilms’ tumors and this isoform may act as a dominant-negative to TrkB signaling. Altered TrkC expression and corresponding gene mutations are seen in various forms of cancer, with increased expression a positive prognostic indicator in patients with medulloblastoma.
产品形式 :
液体
纯化 :
蛋白质A亲和纯化
浓度 :
1微克/微升
储存缓冲液 :
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
储存空调 :
Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
分子量 :
140 kDa
供应商 :
HUABIO
Volume :
100ul
价格 :
355
launch date :
2020&prior
更多信息或购买 :
HUABIO 产品网页
公司信息
HUABIO
Boston, Massachusetts
support@huabio.com
https://www.huabio.com
1-857-353-6600
公司总部: 美国
Founded in 2007, HUABIO is dedicated to developing high-quality antibodies that advance innovation. We are passionate about the accuracy, efficiency, and consistency of our products. That is why we have invested in new production platforms, like recombinant rabbit monoclonals, alpaca nanobodies, and adopted aggressive QA standards to deliver cutting-edge antibodies with uncompromised quality.
We hope to see you at your next discovery!