产品简要
公司名称 :
HUABIO
产品类型 :
抗体
产品名称 :
FUS/TLS重组兔单克隆抗体[JJ09-31](ET1701-86)
目录 :
ET1701-86
规格 :
单克隆
价格 :
JJ09-31
克隆性 :
单克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
克隆名称 :
JJ09-31
反应物种 :
人类
应用 :
免疫印迹, 免疫细胞化学, 流式细胞仪, 免疫组化-石蜡切片
更多信息或购买 :
产品信息
Catalog# :
ET1701-86
产品名称 :
FUS/TLS重组兔单克隆抗体[JJ09-31](ET1701-86)
类别 :
Recombinant Rabbit monoclonal primary
共轭 :
未共轭
克隆性 :
单克隆
克隆编号 :
JJ09-31
宿主 :
兔
应用 :
免疫印迹, 免疫细胞化学, IF, 免疫组化-P, FC
应用w/稀释 :
WB: 1:1, 000;免疫细胞化学/IF:1:50-1:200;免疫组化-P:1:50-1:200;FC:1:50-1:100
反应物种 :
人类, 小鼠, 大鼠
免疫原 :
Synthetic peptide within human aa 1-50.
抗体亚型 :
IgG
靶蛋白 :
FUS/TLS
靶标.UniProt数据库 :
P35637
靶标.同义词 :
75 kDa DNA pairing protein antibody; 75 kDa DNA-pairing protein antibody; ALS6 antibody; Amyotrophic lateral sclerosis 6 antibody; fus antibody; FUS CHOP antibody; Fus like protein antibody; FUS_HUMAN antibody; FUS1 antibody; Fused in sarcoma antibody; Fusion (involved in t(12; 16) in malignant liposarcoma) antibody; Fusion derived from t(12; 16) malignant liposarcoma antibody; Fusion gene in myxoid liposarcoma antibody; Heterogeneous nuclear ribonucleoprotein P2 antibody; hnRNP P2 antibody; hnRNPP2 antibody; Oncogene FUS antibody; Oncogene TLS antibody; POMp75 antibody; RNA binding protein FUS antibody; RNA-binding protein FUS antibody; TLS antibody; TLS CHOP antibody; Translocated in liposarcoma antibody; Translocated in liposarcoma protein antibody
Target function/background :
EWS and FUS/TLS are nuclear RNA-binding proteins. As a result of chromosome translocation, the EWS gene is fused to a variety of transcription factors, including ATF-1, in human neoplasias. In the Ewing family of tumors, the N-terminal domain of EWS is fused to the DNA-binding domain of various Ets transcription factors, including Fli-1, ETV1 and FEV. The EWS/Fli-1 chimeric protein acts as a more potent transcriptional activator than Fli-1 and can promote cell transformation. In human myxoid liposarcomas and myeloid leukemias, chromosomal translocation results in the fusion of the N-terminal region of FUS/TLS with the open reading frame of CHOP. In normal cells, FUS/TLS binds to the DNA-binding domains of nuclear steroid receptors and is also present in subpopulations of TFIID complexes, indicating a potential role for FUS/TLS in the processing of primary transcripts that are generated in response to hormone-induced transcription.
产品形式 :
液体
纯化 :
蛋白质A亲和纯化
浓度 :
1微克/微升
储存缓冲液 :
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
储存空调 :
Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
分子量 :
70 kDa
供应商 :
HUABIO
Volume :
100ul
价格 :
355
launch date :
2020&prior
更多信息或购买 :
公司信息
HUABIO
Founded in 2007, HUABIO is dedicated to developing high-quality antibodies that advance innovation. We are passionate about the accuracy, efficiency, and consistency of our products. That is why we have invested in new production platforms, like recombinant rabbit monoclonals, alpaca nanobodies, and adopted aggressive QA standards to deliver cutting-edge antibodies with uncompromised quality.
We hope to see you at your next discovery!
We hope to see you at your next discovery!