产品简要
公司名称 :
HUABIO
产品类型 :
抗体
产品名称 :
亲环素A重组兔单克隆抗体[JM107-03](ET1703-33)
目录 :
ET1703-33
规格 :
单克隆
价格 :
JM107-03
克隆性 :
单克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
克隆名称 :
JM107-03
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫组化-石蜡切片
更多信息或购买 :
产品信息
Catalog# :
ET1703-33
产品名称 :
亲环素A重组兔单克隆抗体[JM107-03](ET1703-33)
类别 :
Recombinant Rabbit monoclonal primary
共轭 :
未共轭
克隆性 :
单克隆
克隆编号 :
JM107-03
宿主 :
兔
应用 :
免疫印迹, 免疫组化-P
应用w/稀释 :
WB: 1:1, 000-1:5, 000;免疫组化-P:1:50-1:200
反应物种 :
人类, 小鼠, 大鼠
免疫原 :
重组蛋白
抗体亚型 :
IgG
靶蛋白 :
亲环素A
靶标.UniProt数据库 :
P62937
靶标.同义词 :
Cyclophilin A antibody; Cyclophilin antibody; CyclophilinA antibody; Cyclosporin A binding protein antibody; Cyclosporin A-binding protein antibody; CYPA antibody; CYPH antibody; Epididymis secretory sperm binding protein Li 69p antibody; HEL S 69p antibody; MGC117158 antibody; MGC12404 antibody; MGC23397 antibody; Peptidyl prolyl cis trans isomerase A antibody; Peptidyl-prolyl cis-trans isomerase A antibody; Peptidylprolyl isomerase A (cyclophilin A) antibody; Peptidylprolyl isomerase A antibody; PPIA antibody; PPIA protein antibody; PPIA_HUMAN antibody; PPIase A antibody; Rotamase A antibody; RotamaseA antibody; T cell cyclophilin antibody
Target function/background :
The immunosuppressant cyclosporin A (CsA) forms a trimolecular complex with cyclophilin and calcineurins to inhibit calcineurin phosphatase activity. Cyclophilins are conserved, ubiquitous and abundant cytosolic peptidyl-prolyl cis-trans isomerases that accelerate the isomerization of XaaPro peptide bonds and the refolding of proteins. Human cyclophilin A (CyPA), an intracellular protein of 165 amino acids, is the target of the CsA and is encoded by a single unique gene conserved from yeast to humans. CyPA is known for its involvement in T cell differentiation and proliferation and is highly expressed in brain. CyPA is incorporated into the virion of the type 1 human immunodeficiency virus (HIV-1) via a direct interaction with the capsid domain of the viral Gag polyprotein and is crucial for efficient viral replication. Cyclophilin B (CyPB) is a member of the cyclophilin family with specific N- and C-terminal extensions. Unlike CyPA, CyPB has a signal sequence leading to its translocation in the endoplasmic reticulum. CyPB is secreted in biological fluids such as blood or milk and binds to a specific receptor present on the human lymphoblastic cell line Jurkat and on human peripheral blood lymphocytes (9,10).
产品形式 :
液体
纯化 :
蛋白质A亲和纯化
浓度 :
1微克/微升
储存缓冲液 :
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
储存空调 :
Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
分子量 :
18 kDa
供应商 :
HUABIO
Volume :
100ul
价格 :
355
launch date :
2020&prior
更多信息或购买 :
公司信息
HUABIO
Founded in 2007, HUABIO is dedicated to developing high-quality antibodies that advance innovation. We are passionate about the accuracy, efficiency, and consistency of our products. That is why we have invested in new production platforms, like recombinant rabbit monoclonals, alpaca nanobodies, and adopted aggressive QA standards to deliver cutting-edge antibodies with uncompromised quality.
We hope to see you at your next discovery!
We hope to see you at your next discovery!