产品简要
公司名称 :
HUABIO
产品类型 :
抗体
产品名称 :
CD40L重组兔单克隆抗体[JM11-34](ET1703-64)
目录 :
ET1703-64
规格 :
单克隆
价格 :
JM11-34
克隆性 :
单克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
克隆名称 :
JM11-34
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 免疫细胞化学, 流式细胞仪, 免疫组化-石蜡切片
更多信息或购买 :
产品信息
Catalog# :
ET1703-64
产品名称 :
CD40L重组兔单克隆抗体[JM11-34](ET1703-64)
类别 :
Recombinant Rabbit monoclonal primary
共轭 :
未共轭
克隆性 :
单克隆
克隆编号 :
JM11-34
宿主 :
兔
应用 :
免疫印迹, 免疫细胞化学, IF, 免疫组化-P, FC
应用w/稀释 :
WB: 1:500-1:1, 000;免疫细胞化学/IF:1:50-1:200;免疫组化-P:1:50-1:200;FC:1:50-1:100
反应物种 :
人类, 小鼠
免疫原 :
Synthetic peptide within human CD40L aa 100-140.
抗体亚型 :
IgG
靶蛋白 :
CD40L
靶标.UniProt数据库 :
P29965
靶标.同义词 :
CD 40L antibody; CD154 antibody; CD40 antigen ligand antibody; CD40 ligand antibody; CD40 ligand, soluble form antibody; CD40-L antibody; CD40L antibody; CD40L_HUMAN antibody; CD40LG antibody; gp39 antibody; hCD40L antibody; HIGM1 antibody; IGM antibody; IMD3 antibody; T B cell activating molecule antibody; T BAM antibody; T-cell antigen Gp39 antibody; TNF-related activation protein antibody; TNFSF5 antibody; TrAP antibody; Tumor necrosis factor (ligand) superfamily member 5 antibody; Tumor necrosis factor ligand superfamily member 5 antibody
Target function/background :
Resting B cells can be activated and clonally expanded into antibody-producing cells in response to a combination of cell contact and soluble signals provided by primed helper T (Th) cells. While cytokines IL-4 and IL-13 alone are inadequate for B cell activation, contact with Th cells seems to be sufficient for delivery of proliferative signals. CD40 and CD154 (also designated CD40L or TRAP) comprise a receptor ligand pair central to the transmission of this signal. CD40 is expressed on the surface of B cells and CD154 is expressed on activated T cells. In the presence of such stimulus, IL-4 and IL-13 are capable of triggering immunoglobulin class switching and secretion of IgE. CD154 is a 261 amino acid protein that is is expressed as a soluble cytokine as well as a homotrimeric type II transmembrane protein. Its expression is tightly regulated, and abnormal levels of CD154 are associated with the pathogenesis of atheromatous plaque destabilization and thrombotic events. Mutations in the gene encoding for CD154 are implicated in hyper-IgM immunodeficiency syndrome type 1.
产品形式 :
液体
纯化 :
蛋白质A亲和纯化
浓度 :
1微克/微升
储存缓冲液 :
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
储存空调 :
Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
分子量 :
29 kDa
供应商 :
HUABIO
Volume :
100ul
价格 :
355
launch date :
2020&prior
更多信息或购买 :
公司信息
HUABIO
Founded in 2007, HUABIO is dedicated to developing high-quality antibodies that advance innovation. We are passionate about the accuracy, efficiency, and consistency of our products. That is why we have invested in new production platforms, like recombinant rabbit monoclonals, alpaca nanobodies, and adopted aggressive QA standards to deliver cutting-edge antibodies with uncompromised quality.
We hope to see you at your next discovery!
We hope to see you at your next discovery!