产品简要
公司名称 :
HUABIO
产品类型 :
抗体
产品名称 :
突变体p53重组兔单克隆抗体[JB42-26](ET7107-33)
目录 :
ET7107-33
规格 :
单克隆
价格 :
JB42-26
克隆性 :
单克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
克隆名称 :
JB42-26
反应物种 :
人类
应用 :
免疫印迹, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 免疫组化-石蜡切片
更多信息或购买 :
产品信息
Catalog# :
ET7107-33
产品名称 :
突变体p53重组兔单克隆抗体[JB42-26](ET7107-33)
类别 :
Recombinant Rabbit monoclonal primary
共轭 :
未共轭
克隆性 :
单克隆
克隆编号 :
JB42-26
宿主 :
兔
应用 :
免疫印迹, 免疫组化-P, FC, 免疫沉淀, 免疫细胞化学, IF
应用w/稀释 :
WB:1:500;免疫组化-P:1:100;FC:1:50-1:100;ICC:1:100-1:500
反应物种 :
人类
免疫原 :
Synthetic peptide within C-terminal human Mutant p53.
抗体亚型 :
IgG
靶蛋白 :
突变体p53
靶标.UniProt数据库 :
P04637
靶标.同义词 :
Antigen NY-CO-13 antibody; BCC7 antibody; Cellular tumor antigen p53 antibody; LFS1 antibody; Mutant tumor protein 53 antibody; p53 tumor suppressor antibody; P53_HUMAN antibody; Phosphoprotein p53 antibody; Tp53 antibody; Transformation related protein 53 antibody; TRP53 antibody; Tumor protein p53 antibody; Tumor suppressor p53 antibody
Target function/background :
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression.
产品形式 :
液体
纯化 :
蛋白质A亲和纯化
浓度 :
1微克/微升
储存缓冲液 :
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
储存空调 :
Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
分子量 :
53 kDa
供应商 :
HUABIO
Volume :
100ul
价格 :
359
launch date :
2020&prior
更多信息或购买 :
公司信息
HUABIO
Founded in 2007, HUABIO is dedicated to developing high-quality antibodies that advance innovation. We are passionate about the accuracy, efficiency, and consistency of our products. That is why we have invested in new production platforms, like recombinant rabbit monoclonals, alpaca nanobodies, and adopted aggressive QA standards to deliver cutting-edge antibodies with uncompromised quality.
We hope to see you at your next discovery!
We hope to see you at your next discovery!