产品简要
公司名称 :
HUABIO
产品类型 :
抗体
产品名称 :
DSG1重组兔单克隆抗体[JB19-46](ET7107-83)
目录 :
ET7107-83
规格 :
单克隆
价格 :
JB19-46
克隆性 :
单克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
克隆名称 :
JB19-46
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 免疫组化-石蜡切片
更多信息或购买 :
产品信息
Catalog# :
ET7107-83
产品名称 :
DSG1重组兔单克隆抗体[JB19-46](ET7107-83)
类别 :
Recombinant Rabbit monoclonal primary
共轭 :
未共轭
克隆性 :
单克隆
克隆编号 :
JB19-46
宿主 :
兔
应用 :
免疫印迹, 免疫组化-P
应用w/稀释 :
免疫组化-P:1:50-1:200;WB:1:500
反应物种 :
人类, 小鼠
免疫原 :
重组蛋白
抗体亚型 :
IgG
靶蛋白 :
DSG1
靶标.UniProt数据库 :
Q02413
靶标.同义词 :
Cadherin family member 4 antibody; CDHF4 antibody; Desmoglein-1 antibody; Desmosomal glycoprotein 1 antibody; DG1 antibody; DGI antibody; DSG antibody; DSG1 antibody; DSG1_HUMAN antibody; EPKHE antibody; EPKHIA antibody; Pemphigus foliaceus antigen antibody; PPKS1 antibody; SPPK1 antibody
Target function/background :
Desmogleins (dsgs) are type I membrane proteins that are important for cell adhesion and are expressed in great abundance at the desmosomes, which are adhesive cell junctions. The dsg proteins belong to the cadherin family and consist of dsg1, dsg2 and dsg3. Calcium binds to the putative calcium binding sites at the extracellular N-terminal domain of dsg1, which has cadherin-like repeats. Unlike normal human keratinocytes, the squamous cell carcinoma cells exhibit diminished or unusual expression of dsg3 and dsg1, which bear pemphigus vulgaris and pemphigus foliaceus antigens, respectively. Cultured normal human keratinocytes express dsg1 and dsg3 mRNA, with or without dsg 2 mRNA, which indicates that desmoglein isoforms exhibit abnormal expression and may be related to tumor cell kinetics, such as cell invasion and metastasis. Pemphigus is an autoimmune disease of skin adhesion associated with auto-antibodies against a number of keratinocyte antigens, such as the adhesion molecules dsg 1 and 3 and acetylcholine receptors.
产品形式 :
液体
纯化 :
蛋白质A亲和纯化
浓度 :
1微克/微升
储存缓冲液 :
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
储存空调 :
Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
分子量 :
Predicted band size 114 kDa
供应商 :
HUABIO
Volume :
100ul
价格 :
355
launch date :
2020&prior
更多信息或购买 :
公司信息
HUABIO
Founded in 2007, HUABIO is dedicated to developing high-quality antibodies that advance innovation. We are passionate about the accuracy, efficiency, and consistency of our products. That is why we have invested in new production platforms, like recombinant rabbit monoclonals, alpaca nanobodies, and adopted aggressive QA standards to deliver cutting-edge antibodies with uncompromised quality.
We hope to see you at your next discovery!
We hope to see you at your next discovery!