产品简要
公司名称 :
HUABIO
产品类型 :
抗体
产品名称 :
ELMO1重组兔单克隆抗体[JG34-59](ET7108-06)
目录 :
ET7108-06
规格 :
单克隆
价格 :
JG34-59
克隆性 :
单克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
克隆名称 :
JG34-59
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫沉淀, 流式细胞仪, 免疫组化-石蜡切片
更多信息或购买 :
产品信息
Catalog# :
ET7108-06
产品名称 :
ELMO1重组兔单克隆抗体[JG34-59](ET7108-06)
类别 :
Recombinant Rabbit monoclonal primary
共轭 :
未共轭
克隆性 :
单克隆
克隆编号 :
JG34-59
宿主 :
兔
应用 :
免疫印迹, 免疫组化-P, FC, 免疫沉淀
应用w/稀释 :
WB: 1:500-1:2, 000;免疫组化-P:1:50-1:200;FC:1:50-1:100;IP:1:50-1:100
反应物种 :
人类, 小鼠, 大鼠
免疫原 :
Synthetic peptide within C-terminal Human ELMO1 .
抗体亚型 :
IgG
靶蛋白 :
ELMO1
靶标.UniProt数据库 :
Q92556
靶标.同义词 :
CED 12 antibody; Ced 12 homolog 1 antibody; Ced 12 homolog antibody; CED-12 antibody; CED12 antibody; Ced12 homolog 1 antibody; Ced12 homolog antibody; ELMO 1 antibody; ELMO-1 antibody; Elmo1 antibody; ELMO1_HUMAN antibody; Engulfment and cell motility 1 antibody; Engulfment and cell motility protein 1 antibody; KIAA0281 antibody; MGC126406 antibody; Protein ced-12 homolog antibody
Target function/background :
Elmo (engulfment and cell motility) proteins share similarity to C. elegans CED-12. The C. elegans genes ced-2, ced-5, ced-10 and ced-12, and their mammalian homologs, CRKII, DOCK1, RAC1 and ELMO, mediate cytoskeletal rear-rangements during phagocytosis of apoptotic cells as well as cell motility. Elmo1 associates with DOCK 180 and may influence phagocytosis and effect cell shape changes. Src family kinase-mediated tyrosine phosphorylation of Elmo1 influences signaling through Elmo1/Crk/DOCK 180 pathways. Elmo2 interacts directly with Rho G in a GTP-dependent manner and forms a ternary complex with DOCK 180 to induce activation of Rac 1. The Rho G-Elmo2-DOCK 180 pathway is required for activation of Rac 1 and cell spreading mediated by integrin, as well as for neurite outgrowth induced by nerve growth factor. Elmo3 acts in assocation with DOCK 180 and Crk II and may be required in complex with DOCK 180 to activate Rac/Rho small GTPases.
产品形式 :
液体
纯化 :
蛋白质A亲和纯化
浓度 :
1微克/微升
储存缓冲液 :
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
储存空调 :
Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
分子量 :
84 kDa
供应商 :
HUABIO
Volume :
100ul
价格 :
355
launch date :
2020&prior
更多信息或购买 :
公司信息
HUABIO
Founded in 2007, HUABIO is dedicated to developing high-quality antibodies that advance innovation. We are passionate about the accuracy, efficiency, and consistency of our products. That is why we have invested in new production platforms, like recombinant rabbit monoclonals, alpaca nanobodies, and adopted aggressive QA standards to deliver cutting-edge antibodies with uncompromised quality.
We hope to see you at your next discovery!
We hope to see you at your next discovery!