产品简要
公司名称 :
HUABIO
产品类型 :
抗体
产品名称 :
RPA32/RPA2重组兔单克隆抗体[JE45-59](ET7109-41)
目录 :
ET7109-41
规格 :
单克隆
价格 :
JE45-59
克隆性 :
单克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
克隆名称 :
JE45-59
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫沉淀, 免疫组化-石蜡切片
更多信息或购买 :
HUABIO 产品网页
产品信息
Catalog# :
ET7109-41
产品名称 :
RPA32/RPA2重组兔单克隆抗体[JE45-59](ET7109-41)
类别 :
Recombinant Rabbit monoclonal primary
共轭 :
未共轭
克隆性 :
单克隆
克隆编号 :
JE45-59
宿主 :
兔
应用 :
免疫印迹, 免疫沉淀, 免疫组化-P
应用w/稀释 :
WB: 1:500-1:2, 000;IP:1:10-1:50免疫组化-P:1:50-1:200
反应物种 :
人类, 小鼠, 大鼠
免疫原 :
Recombinant protein within C-terminal human RPA32/RPA2.
抗体亚型 :
IgG
靶蛋白 :
RPA32/RPA2
靶标.UniProt数据库 :
P15927
靶标.同义词 :
60S acidic ribosomal protein P1 antibody; AA409079 antibody; AI325195 antibody; AU020965 antibody; ik:tdsubc_2g1 antibody; M(2)21C antibody; MGC137236 antibody; OTTHUMP00000004008 antibody; p32 antibody; p34 antibody; RCJMB04_6d17 replication protein A2, 32kDa antibody; REPA2 antibody; Replication factor A protein 2 antibody; Replication protein A 32 kDa subunit antibody; Replication protein A 32kDa subunit antibody; Replication protein A 34 kDa subunit antibody; Replication protein A antibody; Replication Protein A2 (32kDa) antibody; Replication protein A2 antibody; Replication protein A2, 32kDa antibody; RF-A protein 2 antibody; Rf-A2 antibody; RFA antibody; RFA2_HUMAN antibody; RP-A p32 antibody; RP-A p34 antibody; RP21C antibody; RPA 2 antibody; RPA 32 antibody; RPA antibody; Rpa2 antibody; RPA32 antibody; RPA34 antibody; RpLP1 antibody; RpP2 antibody; xx:tdsubc_2g1 antibody; zgc:109822 antibody
Target function/background :
As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Plays also a role in base excision repair (BER) probably through interaction with UNG. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance.
产品形式 :
液体
纯化 :
蛋白质A亲和纯化
浓度 :
1微克/微升
储存缓冲液 :
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
储存空调 :
Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
分子量 :
32 kDa
供应商 :
HUABIO
Volume :
100ul
价格 :
355
launch date :
2020&prior
更多信息或购买 :
HUABIO 产品网页
公司信息
HUABIO
Boston, Massachusetts
support@huabio.com
https://www.huabio.com
1-857-353-6600
公司总部: 美国
Founded in 2007, HUABIO is dedicated to developing high-quality antibodies that advance innovation. We are passionate about the accuracy, efficiency, and consistency of our products. That is why we have invested in new production platforms, like recombinant rabbit monoclonals, alpaca nanobodies, and adopted aggressive QA standards to deliver cutting-edge antibodies with uncompromised quality.
We hope to see you at your next discovery!