抗体

CD3 epsilon Recombinant Rabbit Monoclonal Antibody [JE17-74] (ET7110-63)

ET7110-63

单克隆

JE17-74

单克隆

domestic rabbit

未共轭

JE17-74

免疫印迹, 流式细胞仪, 免疫组化-石蜡切片

CD3 epsilon Recombinant Rabbit Monoclonal Antibody [JE17-74] (ET7110-63)

Recombinant Rabbit monoclonal primary

未共轭

单克隆

JE17-74

兔

免疫印迹, 免疫组化-P, FC

WB:1:500-1:2, 000;免疫组化-P:1:50;FC:1:50-1:100

人类

Synthetic peptide corresponding to C-terminal Human CD3 epsilon.

IgG

CD3 epsilon

P07766

T-cell surface glycoprotein CD3 epsilon antibody; T3E antibody; TCRE antibody; TiT3 antibody

The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways (PubMed:2470098). In addition of this role of signal transduction in T-cell activation, CD3E plays an essential role in correct T-cell development. Initiates the TCR-CD3 complex assembly by forming the two heterodimers CD3D/CD3E and CD3G/CD3E. Participates also in internalization and cell surface down-regulation of TCR-CD3 complexes via endocytosis sequences present in CD3E cytosolic region.

液体

蛋白质A亲和纯化

1微克/微升

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.

23 kDa

HUABIO

100ul

355

2020&prior