产品简要
公司名称 :
HUABIO
产品类型 :
抗体
产品名称 :
XPD重组兔单克隆抗体[JE55-02](ET7110-93)
目录 :
ET7110-93
规格 :
单克隆
价格 :
JE55-02
克隆性 :
单克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
克隆名称 :
JE55-02
反应物种 :
人类
应用 :
免疫印迹, 免疫组化-石蜡切片
更多信息或购买 :
产品信息
Catalog# :
ET7110-93
产品名称 :
XPD重组兔单克隆抗体[JE55-02](ET7110-93)
类别 :
Recombinant Rabbit monoclonal primary
共轭 :
未共轭
克隆性 :
单克隆
克隆编号 :
JE55-02
宿主 :
兔
应用 :
免疫印迹, 免疫组化-P
应用w/稀释 :
WB:1:500-1:1, 000;免疫组化-P:1:50
反应物种 :
人类
免疫原 :
重组蛋白
抗体亚型 :
IgG
靶蛋白 :
XPD
靶标.UniProt数据库 :
P18074
靶标.同义词 :
TFIIH 80 kDa subunit antibody; Basic transcription factor 2 80 kDa subunit antibody; BTF2 p80 antibody; COFS 2 antibody; COFS2 antibody; CXPD antibody; DNA excision repair protein ERCC 2 antibody; DNA excision repair protein ERCC-2 antibody; DNA repair protein complementing XP D cells antibody; DNA repair protein complementing XP-D cells antibody; EM9 antibody; ERCC 2 antibody; ERCC2 antibody; ERCC2_HUMAN antibody; Excision repair 2 antibody; Excision repair cross complementing rodent repair deficiency complementation antibody; Excision repair cross complementing rodent repair deficiency, complementation group 2 antibody; MAG antibody; MGC102762 antibody; MGC126218 antibody; MGC126219 antibody; OTTHUMP00000045860 antibody; OTTHUMP00000045861 antibody; OTTHUMP00000045862 antibody; OTTHUMP00000045863 antibody; TFIIH 80 kDa subunit antibody; TFIIH basal transcription factor complex 80 kDa subunit antibody; TFIIH Basal Transcription Factor Complex Helicase Subunit antibody; TFIIH basal transcription factor complex helicase XPD subunit antibody; TFIIH basal transcription factor complex p80 subunit antibody; TFIIH p80 antibody; TTD antibody; Xeroderma pigmentosum complementary group D antibody; Xeroderma pigmentosum group D complementing protein antibody; Xeroderma pigmentosum group D-complementing protein antibody; XPD antibody; XPDC antibody
Target function/background :
ATP-dependent 5'-3' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATP-dependent helicase activity of XPD/ERCC2 is required for DNA opening. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. XPD/ERCC2 acts by forming a bridge between CAK and the core-TFIIH complex. Involved in the regulation of vitamin-D receptor activity. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation. Might have a role in aging process and could play a causative role in the generation of skin cancers.
产品形式 :
液体
纯化 :
蛋白质A亲和纯化
浓度 :
1微克/微升
储存缓冲液 :
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
储存空调 :
Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
分子量 :
Predicted band size: 87 kDa
供应商 :
HUABIO
Volume :
100ul
价格 :
355
launch date :
2020&prior
更多信息或购买 :
公司信息
HUABIO
Founded in 2007, HUABIO is dedicated to developing high-quality antibodies that advance innovation. We are passionate about the accuracy, efficiency, and consistency of our products. That is why we have invested in new production platforms, like recombinant rabbit monoclonals, alpaca nanobodies, and adopted aggressive QA standards to deliver cutting-edge antibodies with uncompromised quality.
We hope to see you at your next discovery!
We hope to see you at your next discovery!