产品简要
公司名称 :
HUABIO
产品类型 :
抗体
产品名称 :
P53小鼠单克隆抗体[C8-A11](M1312-2)
目录 :
M1312-2
规格 :
单克隆
价格 :
C8-A11
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
C8-A11
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 免疫细胞化学, 免疫组化-石蜡切片
更多信息或购买 :
产品信息
Catalog# :
M1312-2
产品名称 :
P53小鼠单克隆抗体[C8-A11](M1312-2)
类别 :
Mouse monoclonal primary
共轭 :
未共轭
克隆性 :
单克隆
克隆编号 :
C8-A11
宿主 :
小鼠
应用 :
免疫印迹, 免疫细胞化学, 免疫组化-P
应用w/稀释 :
ICC: 1:500- 1:1, 000;免疫组化-P:1:200;WB:1:500
反应物种 :
人类, 小鼠
免疫原 :
多肽
抗体亚型 :
IgG1
靶蛋白 :
P53
靶标.UniProt数据库 :
P04637
靶标.同义词 :
Antigen NY-CO-13 antibody; BCC7 antibody; Cellular tumor antigen p53 antibody; FLJ92943 antibody; LFS1 antibody; Mutant tumor protein 53 antibody; p53 antibody; p53 tumor suppressor antibody; P53_HUMAN antibody; Phosphoprotein p53 antibody; Tp53 antibody; Transformation related protein 53 antibody; TRP53 antibody; Tumor protein 53 antibody; Tumor protein p53 antibody; Tumor suppressor p53 antibody
Target function/background :
Cellular tumor antigen p53 is crucial in multicellular organisms, where it regulates the cell cycle and, thus, functions as a tumor suppressor, preventing cancer. As such, p53 has been described as "the guardian of the genome" because of its role in conserving stability by preventing genome mutation. Activated p53 binds DNA and activates expression of several genes including microRNA miR-34a, WAF1/CIP1 encoding for p21 and hundreds of other down-stream genes. p21 (WAF1) binds to the G1-S/CDK (CDK2) and S/CDK complexes (molecules important for the G1/S transition in the cell cycle) inhibiting their activity. p53 expression can be stimulated by UV light, which also causes DNA damage. In this case, p53 can initiate events leading to tanning.
产品形式 :
液体
纯化 :
蛋白质G亲和纯化
浓度 :
2微克/微升
储存缓冲液 :
1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
储存空调 :
Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
分子量 :
~53kDa
供应商 :
HUABIO
Volume :
100ul
价格 :
325
launch date :
2020&prior
更多信息或购买 :
公司信息
HUABIO
Founded in 2007, HUABIO is dedicated to developing high-quality antibodies that advance innovation. We are passionate about the accuracy, efficiency, and consistency of our products. That is why we have invested in new production platforms, like recombinant rabbit monoclonals, alpaca nanobodies, and adopted aggressive QA standards to deliver cutting-edge antibodies with uncompromised quality.
We hope to see you at your next discovery!
We hope to see you at your next discovery!