抗体

糖皮质激素受体甲兔多克隆抗体(R1701-1)

R1701-1

多克隆

多克隆

domestic rabbit

未共轭

人类, 小鼠, 大鼠

免疫印迹, 免疫细胞化学

糖皮质激素受体甲兔多克隆抗体(R1701-1)

Rabbit polyclonal primary

未共轭

多克隆

兔

免疫印迹, 免疫细胞化学

WB: 1:200-1:500;ICC: 1:100-1:500

人类, 小鼠, 大鼠

Recombinant protein within human Glucocorticoid Receptor alpha aa 31-390.

IgG

糖皮质激素受体甲

P04150

GCCR antibody; GCR antibody; Glucocorticoid receptor alpha isoform antibody; Glucocorticoid receptor antibody; GR antibody; GRL antibody; NR3C1 antibody; Nuclear receptor subfamily 3 group C member 1 antibody

Glucocorticoids are a family of steroids necessary for the regulation of energy metabolism and the immune and inflammatory responses. These compounds exert their effect through their interaction with the Glucocorticoid Receptor (GR) and that complex's subsequent association with DNA. All normal mammalian tissues examined to date have been shown to contain GR. The human GR exists in two forms, alpha and beta, which are thought to be the result of alternative splicing of a single gene. Sequence analysis indicates that alpha and beta forms of human GR are 777 and 742 amino acids long, respectively. They are identical up to residue 727, after which they diverge. After ligand binding, the 94 kDa GR alpha isoform translocates from the cytoplasm to the nucleus where it regulates gene expression. In contrast, the 90 kDa GR beta isoform does not appear to bind either glucocorticoid agonists or antagonists, and has been localized predominantly in the nucleus independent of hormone treatment in some human cell lines. Studies suggest that human GR alpha has a greater affinity for GR response elements (GREs) than GR beta only when in the ligand bound state.

液体

蛋白质A亲和纯化

1微克/微升

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.

86/76/60 kDa

HUABIO

100ul

295

2020&prior